Acute kidney disease and renal recovery : consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup

Consensus definitions have been reached for both acute kidney injury (AKI) and chronic kidney disease (CKD) and these definitions are now routinely used in research and clinical practice. The KDIGO guideline defines AKI as an abrupt decrease in kidney function occurring over 7 days or less, whereas CKD is defined by the persistence of kidney disease for a period of > 90 days. AKI and CKD are increasingly recognized as related entities and in some instances probably represent a continuum of the disease process. For patients in whom pathophysiologic processes are ongoing, the term acute kidney disease (AKD) has been proposed to define the course of disease after AKI; however, definitions of AKD and strategies for the management of patients with AKD are not currently available. In this consensus statement, the Acute Disease Quality Initiative (ADQI) proposes definitions, staging criteria for AKD, and strategies for the management of affected patients. We also make recommendations for areas of future research, which aim to improve understanding of the underlying processes and improve outcomes for patients with AKD

Src family kinases and their role in hematological malignancies

The Src family protein tyrosine kinases (SFKs) are non-receptor intracellular kinases that have important roles in both hematopoiesis and leukemogenesis. The derangement of their expression or activation has been demonstrated to contribute to hematological malignancies. This review first examines the mechanisms of SFK overexpression and hyperactivation, emphasizing the dysregulation of the upstream modulators. Subsequently, the role of SFK up-regulation in the initiation, progression and therapy resistance of many hematological malignancies is also analyzed. The presented evidence endeavors to highlight the influence of SFK up-regulation on an extensive number of hematological malignancies and the need to consider them as candidates in targeted anticancer therapy

Premium offerings in the sharing economy: Authentic immersions

Over the past few years the sharing economy has grown tremendously, driven in part by traveler desires for authentic and unique experiences. In response to these modern changes, peer-to-peer (P2P) marketplaces (e.g., Airbnb) are seeking additional revenue streams, expanding beyond room rentals into guided tours, recreational, and cultural experiences. Rather than act solely as sharing economy lodging establishments, in the near future providers will increasingly supply authentic and immersive vacation experiences, acting as a host, guide, concierge, and traveling companion to their guests. This paper explores the ability of P2P providers to command premium pricing for authentic and immersive P2P offerings. The paper details this possibility, listing drivers of change before positing a scenario that helps envision a future in which P2P providers seize this opportunity. Finally, the paper closes with limitations, practical implications, and future research recommendations