Allergic sensitisation in tuberculosis patients at the time of diagnosis and following chemotherapy

<p>Abstract</p> <p>Background</p> <p>It is still a matter of debate whether there is an association between infection with <it>Mycobacterium tuberculosis </it>(<it>M. tuberculosis</it>) and allergy. Previously, we have shown higher levels of specific IgE to different inhalant allergens and total IgE in tuberculosis (TB) patients compared to controls. The objectives of this study were to evaluate a possible change in allergic sensitisation after successful TB treatment and to confirm the finding of our previous study of enhanced allergic sensitisation in TB patients compared to controls in a more controlled setting. Additionally, we wanted to determine the cytokine profile in the same groups and finally to evaluate the association between the presence of Bacillus Calmette-Guérin vaccination (BCG) scar and allergic sensitisation among the controls.</p> <p>Methods</p> <p>Sera were analysed for specific IgE to inhalant allergens (Phadiatop) and total IgE by the use of ImmunoCAP 1000 (Pharmacia Diagnostics). Thirteen different cytokines were also analysed in the sera by multiplex bead immunoassay (Luminex 100, Luminex Corporation), and clinical symptoms of allergy and BCG scar were reported in a questionnaire.</p> <p>Results</p> <p>A reduction in levels of specific and total IgE were observed after successful TB treatment. TB patients also had higher levels of specific and total IgE compared to healthy controls. Both interleukin (IL)-6 and interferon (IFN)γ were higher in TB patients compared to healthy controls. The levels of IL-6 were reduced after successful TB treatment. The presence of a BCG scar was associated with a reduced risk of developing allergic sensitisation.</p> <p>Conclusion</p> <p>We observed a reduced level of allergic sensitisation after successful TB treatment. TB patients seem to be more allergically sensitised than healthy controls, confirming our previous finding. Furthermore, we observed an inverse association between allergic sensitisation and visible BCG scar, which adds additional support to the hygiene hypothesis.</p

EM Task 9 - Centrifugal Membrane Filtration

This project is designed to establish the utility of a novel centrifugal membrane filtration technology for the remediation of liquid mixed waste streams at US Department of Energy (DOE) facilities in support of the DOE Environmental Management (EM) program. The Energy and Environmental Research Center (EERC) has teamed with SpinTek Membrane Systems, Inc., a small business and owner of the novel centrifugal membrane filtration technology, to establish the applicability of the technology to DOE site remediation and the commercial viability of the technology for liquid mixed waste stream remediation. The technology is a uniquely configured process that makes use of ultrafiltration and centrifugal force to separate suspended and dissolved solids from liquid waste streams, producing a filtered water stream and a low-volume contaminated concentrate stream. This technology has the potential for effective and efficient waste volume minimization, the treatment of liquid tank wastes, the remediation of contaminated groundwater plumes, and the treatment of secondary liquid waste streams from other remediation processes, as well as the liquid waste stream generated during decontamination and decommissioning activities

CENTRIFUGAL MEMBRANE FILTRATION

The overall project consists of several integrated research phases related to the applicability, continued development, demonstration, and commercialization of the SpinTek centrifugal membrane filtration process. Work performed during this reporting period consisted of Phase 2 evaluation of the SpinTek centrifugal membrane filtration technology and Phase 3, Technology Partnering. During Phase 1 testing conducted at the EERC using the SpinTek ST-IIL unit operating on a surrogate tank waste, a solids cake developed on the membrane surface. The solids cake was observed where linear membrane velocities were less than 17.5 ft/s and reduced the unobstructed membrane surface area up to 25%, reducing overall filtration performance. The primary goal of the Phase 2 research effort was to enhance filtration performance through the development and testing of alternative turbulence promoter designs. The turbulence promoters were designed to generate a shear force across the entire membrane surface sufficient to maintain a self-cleaning membrane capability and improve filtration efficiency and long-term performance. Specific Phase 2 research activities included the following: System modifications to accommodate an 11-in.-diameter, two-disk rotating membrane assembly; Development and fabrication of alternative turbulence promoter designs; Testing and evaluation of the existing and alternative turbulence promoters under selected operating conditions using a statistically designed test matrix; and Data reduction and analysis; The objective of Phase 3 research was to demonstrate the effectiveness of SpinTek's centrifugal membrane filtration as a pretreatment to remove suspended solids from a liquid waste upstream of 3M's WWL cartridge technology for the selective removal of technetium (Tc)

Thank you to our 2017 peer reviewers

Author Posting. © American Geophysical Union, 2018. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Oceans 123 (2018): 6042-6052, doi:10.1029/2018JC014410.Similar to the construction of physical ships and laboratory buildings, scientific knowledge is built incrementally and requires solid components of data, theory, and methodology at each phase of the “construction.” The peer‐review process provides the necessary “inspection” and the assurance that every step of the construction is solid, particularly in regard to the proper use of the scientific method. The peer‐review process helps improve the published work by providing constructive suggestions and by safeguarding against scientific work that could later be found to be built on shaky foundations. Because no single scientist has intimate knowledge of today's many aspects of the Ocean Sciences, we rely on each other's expertise to serve as unbiased “inspectors” of published articles. Your considerable time and effort, spent reviewing JGR‐Oceans manuscript(s) during 2017, are sincerely appreciated by our editorial board and by the Ocean Science community at large. We thank you for rising to this professional challenge and for your wisdom, commitment, skill, and service.2019-03-1

Coseismic fault slip of the 2008 M[sub w] 7.9 Wenchuan earthquake estimated from InSAR and GPS measurements

2009-2010 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Complement activation predicts negative outcomes in COVID-19: The experience from Northen Italian patients

Coronavirus disease 19 (COVID-19) may present as a multi-organ disease with a hyperinflammatory and prothrombotic response (immunothrombosis) in addition to upper and lower airway involvement. Previous data showed that complement activation plays a role in immunothrombosis mainly in severe forms. The study aimed to investigate whether complement involvement is present in the early phases of the disease and can be predictive of a negative outcome. We enrolled 97 symptomatic patients with a positive RT-PCR for SARS-CoV-2 presenting to the emergency room. The patients with mild symptoms/lung involvement at CT-scan were discharged and the remaining were hospitalized. All the patients were evaluated after a 4-week follow-up and classified as mild (n. 54), moderate (n. 17) or severe COVID-19 (n. 26). Blood samples collected before starting any anti-inflammatory/immunosuppressive therapy were assessed for soluble C5b-9 (sC5b-9) and C5a plasma levels by ELISA, and for the following serum mediators by ELLA: IL-1β, IL-6, IL-8, TNFα, IL-4, IL-10, IL-12p70, IFNγ, IFNα, VEGF-A, VEGF-B, GM-CSF, IL-2, IL-17A, VEGFR2, BLyS. Additional routine laboratory parameters were measured (fibrin fragment D-dimer, C-reactive protein, ferritin, white blood cells, neutrophils, lymphocytes, monocytes, platelets, prothrombin time, activated partial thromboplastin time, and fibrinogen). Fifty age and sex-matched healthy controls were also evaluated. SC5b-9 and C5a plasma levels were significantly increased in the hospitalized patients (moderate and severe) in comparison with the non-hospitalized mild group. SC5b9 and C5a plasma levels were predictive of the disease severity evaluated one month later. IL-6, IL-8, TNFα, IL-10 and complement split products were higher in moderate/severe versus non-hospitalized mild COVID-19 patients and healthy controls but with a huge heterogeneity. SC5b-9 and C5a plasma levels correlated positively with CRP, ferritin values and the neutrophil/lymphocyte ratio. Complement can be activated in the very early phases of the disease, even in mild non-hospitalized patients. Complement activation can be observed even when pro-inflammatory cytokines are not increased, and predicts a negative outcome

Communicating public avalanche warnings – what works?

Like many other mountainous countries, Norway has experienced a rapid increase in both recreational winter activities and fatalities in avalanche terrain during the past few decades: during the decade 2008–2017, 64 recreational avalanche fatalities were recorded in Norway. This is a 106&thinsp;% increase from that of the previous decade. In 2013, Norway therefore launched the National Avalanche Warning Service (NAWS), which provides avalanche warnings to transport and preparedness authorities and to the public. Previous studies suggest that avalanche warnings are used extensively in trip and preparedness planning and have a relatively strong influence on the decisions people make in order to reduce risk. However, no evaluation concerning how efficiently the warnings are communicated and understood has been done to date in Norway. Avalanche warnings communicate complex natural phenomena with a variable complexity and level of uncertainty about both the future and the present. In order to manage avalanche risk successfully, it is fundamental that the warning message can be understood and translated into practice by a wide range of different user groups. Users with little or no avalanche competence may need simple information to decide when to stay away from avalanche terrain, while professional users may need advanced technical details in order to make their decisions. To evaluate how different modes of communication are understood, and how efficiently the informational content is communicated, we designed and implemented a web-based user survey. The modes of presentation were based on the Varsom.no 2017 version (Varsom.no being the national portal for natural hazard warnings in Norway). We first used a panel of 110 experts from NAWS to answer the survey, and used their answers to establish the indented message of the avalanche warning. We thereafter received responses from 264 users and compared their answers to those of the NAWS experts for the different modes of communication. We developed a method, the comprehension effectiveness score, to test the comprehension. Our empirical analyses suggest that most users find the warning service to be useful and well suited to their needs. However, the effectiveness of a warnings seems to be influenced by the competency of the user and the complexity of the scenarios. We discuss the findings and make recommendations on how to improve communication of avalanche warnings.</p

Rapidity distributions around mid-rapidity of strange particles in Pb-Pb collisions at 158 AA GeV/c

The production at central rapidity of K0s, Lambda, Xi and Omega particles in Pb-Pb collisions at 158 A GeV/c has been measured by the NA57 experiment over a centrality range corresponding to the most central 53% of the inelastic Pb-Pb cross section. In this paper we present the rapidity distribution of each particle in the central rapidity unit as a function of the event centrality. The distributions are analyzed based on hydrodynamical models of the collisions.Comment: 15 pages, 10 figure

Study of the transverse mass spectra of strange particles in Pb-Pb collisions at 158 A GeV/c

The NA57 experiment has collected high statistics, high purity samples of \PKzS and \PgL, $\Xi$ and $\Omega$ hyperons produced in Pb-Pb collisions at 158 $A$ GeV/$c$. In this paper we present a study of the transverse mass spectra of these particles for a sample of events corresponding to the most central 53% of the inelastic Pb-Pb cross-section. We analyse the transverse mass distributions in the framework of the blast-wave model for the full sample and, for the first time at the SPS, as a function of the event centrality.Comment: 22 pages, 14 figures, submitted to J. Phys. G: Nucl. Phy