An Account of the Birth and Growth of Caddo Archeology, as Seen by Review of 50 Caddo Conferences, 1946-2008

Any 50th anniversary should be noticed as a milestone of some sort, whether of a person or a thing. In this case, any of you who can subtract will recognize that from 1946, when the first Caddo Conference occurred, to 2008 is more than 50 years. This is because between 1946 and 1965, there were only eight meetings, and we ran out of things to talk about (or people to agree to host the meetings) and did not meet in 1969. After the 12th meeting in 1970, we have managed to have a meeting every year, and we have maintained a pattern of meeting in a different state of the four encompassing our research area, or at least a different host institution (see Appendix I). We have maintained flexibility by not organizing: no constitution/by-laws, no officers, no members, and no 501c(3) status. This is not uncommon amongst regional archeological conferences, although several have felt the need for more structure as their attendance and publications grew

Identification of quantitative trait loci associated with bone traits and body weight in an F2 resource population of chickens*

Bone fractures at the end of lay are a significant problem in egg-laying strains of hens. The objective of the current study was to identify quantitative trait loci (QTL) associated with bone mineralization and strength in a chicken resource population. Layer (White Leghorn hens) and broiler (Cobb-Cobb roosters) lines were crossed to generate an F2 population of 508 hens over seven hatches, and 26 traits related to bone integrity, including bone mineral density (BMD) and content (BMC), were measured. Genotypes of 120 microsatellite markers on 28 autosomal groups were determined, and interval mapping was conducted to identify QTL regions. Twenty-three tests representing three chromosomal regions (chromosomes 4, 10 and 27) contained significant QTL that surpassed the 5% genome-wise threshold, and 47 tests representing 15 chromosomes identified suggestive QTL that surpassed the 5% chromosome-wise threshold. Although no significant QTL influencing BMD and BMC were detected after adjusting for variation in body weight and egg production, multiple suggestive QTL were found. These results support previous experiments demonstrating an important genetic regulation of bone strength in chickens, but suggest the regulation may be due to the effects of multiple genes that each account for relatively small amounts of variation in bone strength

Chandra Confirmation of a Pulsar Wind Nebula in DA 495

As part of a multiwavelength study of the unusual radio supernova remnant DA 495, we present observations made with the Chandra X-ray Observatory. Imaging and spectroscopic analysis confirms the previously detected X-ray source at the heart of the annular radio nebula, establishing the radiative properties of two key emission components: a soft unresolved source with a blackbody temperature of 1 MK consistent with a neutron star, surrounded by a nonthermal nebula 40'' in diameter exhibiting a power-law spectrum with photon index Gamma = 1.6+/-0.3, typical of a pulsar wind nebula. The implied spin-down luminosity of the neutron star, assuming a conversion efficiency to nebular flux appropriate to Vela-like pulsars, is ~10^{35} ergs/s, again typical of objects a few tens of kyr old. Morphologically, the nebular flux is slightly enhanced along a direction, in projection on the sky, independently demonstrated to be of significance in radio polarization observations; we argue that this represents the orientation of the pulsar spin axis. At smaller scales, a narrow X-ray feature is seen extending out 5'' from the point source, a distance consistent with the sizes of resolved wind termination shocks around many Vela-like pulsars. Finally, we argue based on synchrotron lifetimes in the estimated nebular magnetic field that DA 495 represents a rare pulsar wind nebula in which electromagnetic flux makes up a significant part, together with particle flux, of the neutron star's wind, and that this high magnetization factor may account for the nebula's low luminosity.Comment: 26 pages, 5 figures, AASTeX preprint style. Accepted for publication in The Astrophysical Journa

Topography generation by melting and freezing in a turbulent shear flow

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Letter to the Editor regarding the article: "identifying pre-hospital factors associated with outcome for major trauma patients in a regional trauma network: An exploratory study"

The aim of this Letter to the Editor was to report some methodological shortcomings in a recently published article. Issues regarding missing values and overfitting are mentioned. First, Complete Case (CC) analysis was used instead of an imputation method. Second, there was a high chance of overfitting and lack of model validation. In conclusion, the results of this study should be interpret with caution and further research is necessary

Sex-specific Mendelian randomisation to assess the causality of sex differences in the effects of risk factors and treatment: spotlight on hypertension

Hypertension is a key modifiable risk factor for cardiovascular disease. Several observational studies have found a stronger association of blood pressure and cardiovascular disease risk in women compared to men. Since observational studies can be affected by sex-specific residual confounding and reverse causation, it remains unclear whether these differences reflect actual differential effects. Other study designs are needed to uncover the causality of sex differences in the strength of risk factor and treatment effects. Mendelian randomisation (MR) uses genetic variants as instrumental variables to provide evidence about putative causal relations between risk factors and outcomes. By exploiting the random allocation of genes at gamete forming, MR is unaffected by confounding and results in more reliable causal effect estimates. In this review, we discuss why and how sex-specific MR and cis-MR could be used to study sex differences in risk factor and drug target effects. Sex-specific MR can be helpful to strengthen causal inferences in the field of sex differences, where it is often challenging to distinguish nature from nurture. The challenge of sex-specific (drug target) MR lays in leveraging robust genetic instruments from sex-specific GWAS studies which are not commonly available. Knowledge on sex-specific causal effects of hypertension, or other risk factors, could improve clinical practice and health policies by tailoring interventions based on personalised risk. Drug target MR can help to determine the anticipated on-target effects of a drug compound and to identify targets to pursue in drug developmen