681 research outputs found
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Hemlock Legacy Project (HeLP): A paleoecological requiem for eastern hemlock
Eastern North American forests have effectively lost two major tree species (American chestnut and American elm) in the last 100 years and two more, eastern and Carolina hemlock, will be functionally extinct over much of their ranges within a couple of decades. The loss of eastern hemlock is of particular concern because hemlock is: (1) a foundation species; (2) one of the longest-lived tree species over much of temperate eastern North America; and (3) sensitive to climatic variation and ecosystem disturbance, making it an ideal species for the reconstruction of environmental history. Unlike American chestnut, we have a small window of opportunity to salvage environmental histories from hemlock before they are lost. In this progress report, we review the extensive body of science derived from this paleoenvironmental archive and urge scientists from eastern North America to sample and archive old-growth hemlock while living and dead material remain. Here we describe a community-based approach to salvaging paleoenvironmental archives that could serve as a model for collections from other foundation species currently threatened by exotic forests pests and pathogens (e.g. whitebark pine, ash). The approach supports Schlesinger’s (2010) call for ‘translational ecology’ by building connections between scientists, students, environmental NGOs, and land managers focused on old-growth forests
Robust Machine Learning-Based Correction on Automatic Segmentation of the Cerebellum and Brainstem.
Automated segmentation is a useful method for studying large brain structures such as the cerebellum and brainstem. However, automated segmentation may lead to inaccuracy and/or undesirable boundary. The goal of the present study was to investigate whether SegAdapter, a machine learning-based method, is useful for automatically correcting large segmentation errors and disagreement in anatomical definition. We further assessed the robustness of the method in handling size of training set, differences in head coil usage, and amount of brain atrophy. High resolution T1-weighted images were acquired from 30 healthy controls scanned with either an 8-channel or 32-channel head coil. Ten patients, who suffered from brain atrophy because of fragile X-associated tremor/ataxia syndrome, were scanned using the 32-channel head coil. The initial segmentations of the cerebellum and brainstem were generated automatically using Freesurfer. Subsequently, Freesurfer's segmentations were both manually corrected to serve as the gold standard and automatically corrected by SegAdapter. Using only 5 scans in the training set, spatial overlap with manual segmentation in Dice coefficient improved significantly from 0.956 (for Freesurfer segmentation) to 0.978 (for SegAdapter-corrected segmentation) for the cerebellum and from 0.821 to 0.954 for the brainstem. Reducing the training set size to 2 scans only decreased the Dice coefficient ≤0.002 for the cerebellum and ≤ 0.005 for the brainstem compared to the use of training set size of 5 scans in corrective learning. The method was also robust in handling differences between the training set and the test set in head coil usage and the amount of brain atrophy, which reduced spatial overlap only by <0.01. These results suggest that the combination of automated segmentation and corrective learning provides a valuable method for accurate and efficient segmentation of the cerebellum and brainstem, particularly in large-scale neuroimaging studies, and potentially for segmenting other neural regions as well
Spatially Heterogeneous Estimates of Fire Frequency in Ponderosa Pine Forests of Washington, USA
Many fire history studies have evaluated the temporal nature of fire regimes using fire interval statistics calculated from fire scars. More recently, researchers have begun to evaluate the spatial properties of past fires as well. In this paper, we describe a technique for investigating spatio-temporal variability using a geographic information system (GIS). We used a dataset of fire-scarred trees collected from four sites in eastern Washington, USA, ponderosa pine (Pinus ponderosa C. Lawson) forests. The patterns of past fires recorded by individual trees (points) were converted to two-dimensional representations of fire with inverse distance weighting (IDW) in a GIS. A map overlay approach was then used to extract a fine-grained, spatially explicit reconstruction of fire frequency at the four sites. The resulting classified maps can supplement traditional fire interval statistics and fire atlas data to provide detailed, spatially heterogeneous estimates of fire frequency. Such information can reveal ecological relationships between fire and the landscape, and provide managers with an improved spatial perspective on fire frequency that can inform risk evaluations, fuels reduction efforts, and the allocation of fire-fighting resources
Effects of mavoglurant on visual attention and pupil reactivity while viewing photographs of faces in Fragile X Syndrome.
BackgroundNumerous preclinical studies have supported the theory that enhanced activation of mGluR5 signaling, due to the absence or reduction of the FMR1 protein, contributes to cognitive and behavioral deficits in patients with fragile X syndrome (FXS). However multiple phase 2 controlled trials in patients with FXS have failed to demonstrate efficacy of compounds that negatively modulate mGluR5, including two phase 2b randomized controlled trials (RCT) of mavoglurant (AFQ056, Novartis Pharma AG), when the primary measures of interest were behavioral ratings. This has cast some doubt onto the translation of the mGluR5 theory from animal models to humans with the disorder.MethodsWe evaluated social gaze behavior-a key phenotypic feature of the disorder-and sympathetic nervous system influence on pupil size using a previously-validated eye tracking paradigm as a biobehavioral probe, in 57 adolescent or adult patients with FXS at baseline and following three months of blinded treatment with one of three doses of mavoglurant or placebo, within the context of the AFQ056 RCTs.ResultsPatients with FXS treated with mavoglurant demonstrated increased total absolute looking time and number of fixations to the eye region while viewing human faces relative to baseline, and compared to those treated with placebo. In addition, patients had greater pupil reactivity to faces relative to baseline following mavoglurant treatment compared to placebo.DiscussionThe study shows that negative modulation of mGluR5 activity improves eye gaze behavior and alters sympathetically-driven reactivity to faces in patients with FXS, providing preliminary evidence of this drug's impact on behavior in humans with the disorder
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Privatization, Drought, and Fire Exclusion in the Tuul River Watershed, Mongolia
Global wildfire frequency and extent are expected to increase under projected climate change in the twenty-first century, yet little is known about how human activities might affect this trend. In central Mongolia, there has been a 2.5°C rise in spring and summer temperatures during the last 40 years and a decrease in moisture availability during the latter half of the twentieth century. Concurrently, Mongolia has experienced multiple shifts in socioeconomic systems during the twentieth century, most notably the establishment of a Soviet-backed communist economy in the 1920s and a rapid transition to privatization in the 1990s. Observed records of fire in the late twentieth century suggested that fire activity had increased, but no long-term data existed to place these trends in a historical context. Our objective was to identify spatial and temporal patterns in fire occurrence in the forest-steppe ecotone of the Tuul River watershed in the context of changing climatic and social conditions since 1875. We used fire-scarred trees to reconstruct past fire occurrence during the period 1875–2009. Our results indicate a significant association between human activity and fire occurrence independent of climatic variables. The greatest evidence for an anthropogenic fire regime exists following the transition to a free market economy during the early 1990s when land-use intensification near the capital city of Ulaanbaatar resulted in fire exclusion. We emphasize the importance of including socio-political variables in global models of wildfire potential, particularly where fuels limit fire activity
Evaluating The Effect Of Alternative Carbon Allocation Schemes In A Land Surface Model (Clm4.5) On Carbon Fluxes, Pools And Turnover In Temperate Forests
How carbon (C) is allocated to different plant tissues (leaves, stem and roots) determines C residence time and thus remains a central challenge for understanding the global C cycle. We used a diverse set of observations (AmeriFlux eddy covariance tower observations, biomass estimates from tree-ring data, and Leaf Area Index (LAI) measurements) to compare C fluxes, pools, and LAI data with those predicted by a Land Surface Model (LSM), the Community Land Model (CLM4.5). We ran CLM for nine temperate (including evergreen and deciduous) forests in North America between 1980 and 2013 using four different C allocation schemes: i) Dynamic C allocation scheme (named D-CLM ) with one dynamic allometric parameter, which allocates C to the stem and leaves to vary in time as a function of annual Net Primary Production (NPP). ii) An alternative dynamic C allocation scheme (named D-Litton ), where, similar to (i) C allocation is a dynamic function of annual NPP, but unlike (i) includes two dynamic allometric parameters involving allocation to leaves, stem and coarse roots iii–iv) Two fixed C allocation schemes, one representative of observations in evergreen (named F-Evergreen ) and the other of observations in deciduous forests (named F-Deciduous ). D-CLM generally overestimated Gross Primary Production (GPP) and ecosystem respiration, and underestimated Net Ecosystem Exchange (NEE). In D-CLM, initial aboveground biomass in 1980 was largely overestimated (between 10527 and 12897 g Cm-2) for deciduous forests, whereas aboveground biomass accumulation through time (between 1980 and 2011) was highly underestimated (between 1222 and 7557 g Cm-2) for both evergreen and deciduous sites due to a lower stem turnover rate in the sites than the one used in the model. D-CLM overestimated LAI in both evergreen and deciduous sites because the leaf C-LAI relationship in the model did not match the observed leaf C-LAI relationship at our sites. Although the four C allocation schemes gave similar results for aggregated C fluxes, they translated to important differences in long-term aboveground biomass accumulation and aboveground NPP. For deciduous forests, D-Litton gave more realistic Cstem/Cleaf ratios and strongly reduced the overestimation of initial aboveground biomass, and aboveground NPP for deciduous forests by D-CLM. We identified key structural and parameterization deficits that need refinement to improve the accuracy of LSMs in the near future. That could be done by addressing some of the current model assumptions about C allocation and the associated parameter uncertainty. Our results highlight the importance of using aboveground biomass data to evaluate and constrain the C allocation scheme in the model, and in particular, the sensitivity to the stem turnover rate. Revising these will be critical to improving long-term C processes in LSMs, and improve their projections of biomass accumulation in forests
Broad clinical involvement in a family affected by the fragile X premutation
The mutations in the FMR1 gene have been described as a family of disorders called fragile X-associated disorders including fragile X syndrome, fragile X-associated tremor/ataxia syndrome, primary ovarian insufficiency, and other problems associated with the premutation, such as hypothyroidism, hypertension, neuropathy, anxiety, depression, attention-deficit hyperactivity disorders, and autism spectrum disorders. The premutation is relatively common in the general population affecting 1 of 130 to 250 female individuals and 1 of 250 to 800 male individuals. Therefore, to provide appropriate treatment and genetic counseling for all of the carriers and affected individuals in a family, a detailed family history that reviews many of the disorders that are related to both the premutation and the full mutation should be carried out as exemplified in these cases. To facilitate the integration of this knowledge into clinical practice, this is the first case report that demonstrates only premutation involvement across 3 generations
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