Refurbishing Voyager 1 & 2 Planetary Radio Astronomy (PRA) Data

Voyager/PRA (Planetary Radio Astronomy) data from digitized tapes archived at CNES have been reprocessed and recalibrated. The data cover the Jupiter and Saturn flybys of both Voyager probes. We have also reconstructed goniopolarimetric datasets (flux and polarization) at full resolution. These datasets are currently not available to the scientific community, but they are of primary interest for the analysis of the Cassini data at Saturn, and the Juno data at Jupiter, as well as for the preparation of the JUICE mission. We present the first results derived from the re-analysis of this dataset.Comment: Accepted manuscript for PRE8 (Planetary Radio Emission VIII conference) proceeding

Space plasma physics science opportunities for the lunar orbital platform - Gateway

The Lunar Orbital Platform - Gateway (LOP - Gateway, or simply Gateway) is a crewed platform that will be assembled and operated in the vicinity of the Moon by NASA and international partner organizations, including ESA, starting from the mid-2020s. It will offer new opportunities for fundamental and applied scientific research. The Moon is a unique location to study the deep space plasma environment. Moreover, the lunar surface and the surface-bounded exosphere are interacting with this environment, constituting a complex multi-scale interacting system. This paper examines the opportunities provided by externally mounted payloads on the Gateway in the field of space plasma physics, heliophysics and space weather, and also examines the impact of the space environment on an inhabited platform in the vicinity of the Moon. It then presents the conceptual design of a model payload, required to perform these space plasma measurements and observations. It results that the Gateway is very well-suited for space plasma physics research. It allows a series of scientific objectives with a multi-disciplinary dimension to be addressed

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

How to improve the diagnosis of kinetic energy in deltaf PIC codes

International audienceThis paper propose to analyse the effect of the shape factor that is used in plasma PIC deltaf codes to make interpolations between the grid and the particles positions. In deltaf codes, the total density fluctuates, even when it should be conserved. We show that, in some cases, the computed non-physical part of the particle kinetic energy fluctuations is dependent on those of the total density. We deduce a method that can reduce drastically the statistical fluctuations in the diagnostics of the kinetic energy

Distribution of electron energy and acceleration features in the jovian S-burst emission region

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Jovian millisecond-bursts as markers of Alfvenic electron acceleration

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Simulation of Io-Jupiter radio arcs

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Jovian S burst generation by Alfvén waves

International audienceJupiter's radio emissions are dominated in intensity by decametric radio emissions due to the Io-Jupiter interaction. Previous analyses suggest that these emissions are cyclotron-maser emissions in the flux tubes connecting Io or Io's wake to Jupiter. Electrons responsible for the emission are thought to be accelerated from Io to Jupiter. We present simulations of this hot electron population under the assumption of acceleration by Alfvén waves in the Io flux tube. Outside of limited acceleration regions where a parallel electric field associated with Alfvén waves exists, the electrons are supposed to have an adiabatic motion along the magnetic field lines. Near Jupiter a loss cone appears in the magnetically mirrored electron population, which is able to amplify extraordinary (X) mode radio waves. The X-mode growth rate is computed, which allows us to build theoretical dynamic spectra of the resulting Jovian radio emissions, whose characteristics match those observed for Jovian S bursts