Evaluating the Potential of Using 5-Azacytidine as an Epimutagen

A number of early flowering lines were induced when 5-azacytidine was applied to germinating flax (Linum usitatissimum L.) seed. The genetics of these lines indicate that the induced changes are epigenetic and probably result from demethylation of the genomic DNA at loci that affect flowering age. Although the growth and development of three stable early flowering lines are altered and the percentage of filled seed was reduced in all three lines compared with controls, measures of seed productivity demonstrated that harvest index was unaffected in two of the lines. In the third, harvest index was lower than normal and both seed set per capsule and seed mass per 100 seed were reduced. Furthermore, six generations after induction this line began to display relatively high levels of polyembryony. The late appearance of this twinning and other aspects related to working with lines induced by 5-azacytidine and using 5-azacytidine as an epimutagen are discussed

Positive energy unitary irreducible representations of D=6 conformal supersymmetry

We give a constructive classification of the positive energy (lowest weight) unitary irreducible representations of the D=6 superconformal algebras osp(8*/2N). Our results confirm all but one of the conjectures of Minwalla (for N=1,2) on this classification. Our main tool is the explicit construction of the norms of the states that has to be checked for positivity. We give also the reduction of the exceptional UIRs.Comment: 27 pages, TeX with harvmac, amssym.def, amssym.tex; v.2: minor corrections and references added; v.3: minor corrections; v.4: to appear in J. Phys.

New methods for unmixing sediment grain size data

Grain size distribution (GSD) data are widely used in Earth sciences and although large data sets are regularly generated, detailed numerical analyses are not routine. Unmixing GSDs into components can help understand sediment provenance and depositional regimes/processes. End-member analysis (EMA), which fits one set of end-members to a given data set, is a powerful way to unmix GSDs into geologically meaningful parts. EMA estimates end-members based on covariability within a data set and can be considered as a nonparametric approach. Available EMA algorithms, however, either produce suboptimal solutions or are time consuming. We introduce unmixing algorithms inspired by hyperspectral image analysis that can be applied to GSD data and which provide an improvement over current techniques. Nonparametric EMA is often unable to identify unimodal grain size subpopulations that correspond to single sediment sources. An alternative approach is single-specimen unmixing (SSU), which unmixes individual GSDs into unimodal parametric distributions (e.g., lognormal). We demonstrate that the inherent nonuniqueness of SSU solutions renders this approach unviable for estimating underlying mixing processes. To overcome this, we develop a new algorithm to perform parametric EMA, whereby an entire data set can be unmixed into unimodal parametric end-members (e.g., Weibull distributions). This makes it easier to identify individual grain size subpopulations in highly mixed data sets. To aid investigators in applying these methods, all of the new algorithms are available in AnalySize, which is GUI software for processing and unmixing grain size data

A note on the perturbative properties of BPS operators

We discuss the perturbative behavior of the 1/2 BPS operators in N=2 SCFT on the example of two very similar quadrilinear composite operators made out of hypermultiplets. An explicit one-loop computation shows that one of them is protected while the other acquires an anomalous dimension. Although both operators are superconformal primaries in the free case, the quantum corrections make the latter become a 1/2 BPS descendant of the Konishi multiplet, while the former remains primary. The comparative study of these two operators at higher orders may be helpful in understanding the quantum properties of the Konishi multiplet

Parents’ Perceptions of the Physical Health Outcomes of Young People Diagnosed with First Episode Psychosis

This study explores parents’ perceptions of their son/daughter’s physical health needs following a first episode psychosis diagnosis and commencement on antipsychotic medication. The research process was guided by grounded theory methodology and data were collected using semi-structure interviews with 16 parents. Four categories were identified. Participants described the importance, challenges and strategies for their son/daughter to maintain their physical health, and the need to improve young people’s health literacy, particularly in areas of physical health, diet and lifestyle. These findings will assist health professionals to provide parents with information to better support their son/daughter to maintain their physical health

Fermi surface and order parameter driven vortex lattice structure transitions in twin-free YBa2Cu3O7

We report on small-angle neutron scattering studies of the intrinsic vortex lattice (VL) structure in detwinned YBa2Cu3O7 at 2 K, and in fields up to 10.8 T. Because of the suppressed pinning to twin-domain boundaries, a new distorted hexagonal VL structure phase is stabilized at intermediate fields. It is separated from a low-field hexagonal phase of different orientation and distortion by a first-order transition at 2.0(2) T that is probably driven by Fermi surface effects. We argue that another first-order transition at 6.7(2) T, into a rhombic structure with a distortion of opposite sign, marks a crossover from a regime where Fermi surface anisotropy is dominant, to one where the VL structure and distortion is controlled by the order-parameter anisotropy.Comment: 4 pages, 3 figures (2 color), minor change

Introgression of chromosome segments from multiple alien species in wheat breeding lines with wheat streak mosaic virus resistance

Pyramiding of alien-derived Wheat streak mosaic virus (WSMV) resistance and resistance enhancing genes in wheat is a costeffective and environmentally safe strategy for disease control. PCR-based markers and cytogenetic analysis with genomic in situ hybridisation were applied to identify alien chromatin in four genetically diverse populations of wheat (Triticum aestivum) lines incorporating chromosome segments from Thinopyrum intermedium and Secale cereale (rye). Out of 20 experimental lines, 10 carried Th. intermedium chromatin as T4DL*4Ai#2S translocations, while, unexpectedly, 7 lines were positive for alien chromatin (Th. intermedium or rye) on chromosome 1B. The newly described rye 1RS chromatin, transmitted from early in the pedigree, was associated with enhanced WSMV resistance. Under field conditions, the 1RS chromatin alone showed some resistance, while together with the Th. intermedium 4Ai#2S offered superior resistance to that demonstrated by the known resistant cultivar Mace. Most alien wheat lines carry whole chromosome arms, and it is notable that these lines showed intra-arm recombination within the 1BS arm. The translocation breakpoints between 1BS and alien chromatin fell in three categories: (i) at or near to the centromere, (ii) intercalary between markers UL-Thin5 and Xgwm1130 and (iii) towards the telomere between Xgwm0911 and Xbarc194. Labelled genomic Th. intermedium DNA hybridised to the rye 1RS chromatin under high stringency conditions, indicating the presence of shared tandem repeats among the cereals. The novel small alien fragments may explain the difficulty in developing well-adapted lines carrying Wsm1 despite improved tolerance to the virus. The results will facilitate directed chromosome engineering producing agronomically desirable WSMV-resistant germplasm

Universal properties of superconformal OPEs for 1/2 BPS operators in 3≤D≤63\leq D \leq 6

We give a general analysis of OPEs of 1/2 BPS superfield operators for the $D=3,4,5,6$ superconformal algebras OSp(8/4,R), PSU(2,2), F${}_4$ and OSp($8^*/4$) which underlie maximal AdS supergravity in $4\leq D+1\leq 7$. \\ The corresponding three-point functions can be formally factorized in a way similar to the decomposition of a generic superconformal UIR into a product of supersingletons. This allows for a simple derivation of branching rules for primary superfields. The operators of protected conformal dimension which may appear in the OPE are classified and are shown to be either 1/2 or 1/4 BPS, or semishort. As an application, we discuss the "non-renormalization" of extremal $n$-point correlators.Comment: To be published in NJP Focus Issue: Supersymmetry in condensed matter and high energy physic

Conformally coupled supermultiplets in four and five dimensions

We obtain by superfield methods the exceptional representations of the OSp(2N/4,R) and SU(2,2/1) superalgebras which extend to supersingletons of SU(2,2/2N) and F(4), respectively. These representations describe superconformally coupled multiplets and appear in three- and four-dimensional superconformal field theories which are holographic descriptions of certain anti-de Sitter supergravities

The pairing state in KFe2As2 studied by measurements of the magnetic vortex lattice

Understanding the mechanism and symmetry of electron pairing in iron-based superconductors represents an important challenge in condensed matter physics [1-3]. The observation of magnetic flux lines - "vortices" - in a superconductor can contribute to this issue, because the spatial variation of magnetic field reflects the pairing. Unlike many other iron pnictides, our KFe2As2 crystals have very weak vortex pinning, allowing small-angle-neutron-scattering (SANS) observations of the intrinsic vortex lattice (VL). We observe nearly isotropic hexagonal packing of vortices, without VL-symmetry transitions up to high fields along the fourfold c-axis of the crystals, indicating rather small anisotropy of the superconducting properties around this axis. This rules out gap nodes parallel to the c-axis, and thus d-wave and also anisotropic s-wave pairing [2, 3]. The strong temperature-dependence of the intensity down to T<<Tc indicates either widely different full gaps on different Fermi surface sheets, or nodal lines perpendicular to the axis.Comment: 13 pages, 3 figure