21 research outputs found

    Proceedings of the 13th International Newborn Brain Conference: Neonatal Neurocritical Care, Seizures, and Continuous EEG monitoring

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    The Continuing Case for a Polycentric Approach for Coping with Climate Change

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    Elinor Ostrom argued that effectively coping with manmade climate change requires a polycentric approach. Although we agree with Ostrom’s assessment, her arguments regarding the advantages of polycentricity could be taken further. In this paper, we supplement Ostrom’s work by fleshing out the reasons of how and why a polycentric approach is more conducive to coping with climate change than national governments that attempt to centrally direct climate change policies. We argue that there are at least six advantages that polycentric systems have for coping with climate change: competition among decision makers, cooperation among decision makers, perceptions of legitimacy that lead to coproduction, mutual learning through experimentation, institutional resilience/robustness, and emergent outcomes that are socially desirable but not centrally planned. The combination of these six factors gives polycentric governance systems distinct advantages over more top-down ones, especially in terms of epistemics and incentive compatibility. Scholars and policymakers who are concerned about the implications of climate change should appreciate the many diverse and nuanced advantages of a polycentric approach for coping with climate change

    Seizure Severity and Treatment Response in Newborn Infants with Seizures Attributed to Intracranial Hemorrhage.

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    We sought to characterize intracranial hemorrhage (ICH) as a seizure etiology in infants born term and preterm. For infants born term, we sought to compare seizure severity and treatment response for multisite vs single-site ICH and hypoxic-ischemic encephalopathy (HIE) with vs without ICH. We studied 112 newborn infants with seizures attributed to ICH and 201 infants born at term with seizures attributed to HIE, using a cohort of consecutive infants with clinically diagnosed and/or electrographic seizures prospectively enrolled in the multicenter Neonatal Seizure Registry. We compared seizure severity and treatment response among infants with complicated ICH, defined as multisite vs single-site ICH and HIE with vs without ICH. ICH was a more common seizure etiology in infants born preterm vs term (27% vs 10%, P < .001). Most infants had subclinical seizures (74%) and an incomplete response to initial antiseizure medication (ASM) (68%). In infants born term, multisite ICH was associated with more subclinical seizures than single-site ICH (93% vs 66%, P = .05) and an incomplete response to the initial ASM (100% vs 66%, P = .02). Status epilepticus was more common in HIE with ICH vs HIE alone (38% vs 17%, P = .05). Seizure severity was greater and treatment response was lower among infants born term with complicated ICH. These data support the use of continuous video electroencephalogram monitoring to accurately detect seizures and a multistep treatment plan that considers early use of multiple ASMs, particularly with parenchymal and high-grade intraventricular hemorrhage and complicated ICH
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