AKSI KOMPETENSI BERSAMA DI PANTI ASUHAN MISI NUSANTARA SURAKARTA

Permasalahan sosial yang banyak terjadi di masyarakat adalah kaum marjinal yang terpinggirkan seperti anak terlantar, anak jalanan, pengemis, dan sebagainya. Salah satu upaya mengatasi masalah kaum marjinal yaitu dengan didirikan lembaga sosial berupa panti asuhan anak. Sejak masa pandemi, anak di Panti Asuhan Misi Nusantara Surakarta jarang mendapat layanan kesehatan dan ada keterbatasan ruang gerak anak-anak. Tujuan pengabdian masyarakat ini untuk membantu panti asuhan dalam memantau pertumbuhan dan perkembangan penghuni dan pengelola Panti Asuhan Misi Nusantara di Surakarta. Metoda pelaksanaan berupa pemeriksaan tumbuh kembang anak, Penyuluhan Hidup Bersih dan Sehat, pemeriksaan Status Gizi Anak, penyuluhan cara menyikat gigi yang benar, pemeriksaan kesehatan pengelola panti asuhan serta pelatihan penanggulangan bencana. Hasil pemeriksaan Kesehatan pada penghuni dan pengelola panti didapatkan sebagian besar (52,6%) penghuni panti berjenis kelamin laki-laki, hampir setengahnya berusia rata-rata 21-60 tahun, Sebagian besar (68,4%) tekanan darah <140/90 mmHg, Sebagian besar (73,1%) berstatus gizi normal, hampir seluruhnya (94,4%) glukosa darah <126 m/dL dan asam urat <8 mg/dL. Secara umum keadaan warga panti asuhan dalam keadaan baik Social problems that often occur in society are abandoned children, street children, beggars, disabled people, neglected elderly, poor families, families with social problems, and so on. Children and poor people should have their human rights fulfilled by the State of Indonesia. However, in reality there are many children whose needs are not met, such as parents who are unable to provide for the child's needs or the child does not have parents. One effort to overcome this is to establish social institutions in the form of orphanages. Since the pandemic, children at the Mission Nusantara Surakarta Orphanage rarely receive health services and there is limited space for children to move. The purpose of this community service is to assist the orphanage in monitoring the growth and development of residents and managers of the Mission Nusantara Orphanage in Surakarta. The implementation method is in the form of examinations on child growth and development, Counseling on Clean and Healthy Living, checking on the Nutritional Status of Children, counseling on how to brush their teeth properly, health checks for orphanage managers and training on disaster management. 6%) of the residents of the orphanage are male, almost half of them are aged 21-60 years, most (68.4%) have blood pressure < 140/90 mmHg, most (73.1%) have normal nutritional status, almost all (94.4%) blood glucose < 126 m/dL and uric acid > 8 mg/dl. Similar activities are needed to see general body health and must be monitored periodically, so that the residents of the orphanage can find out their health status, especially now that they are still in a pandemic condition Covid-1

Garcinoxanthones from Garcinia mangostana L. against SARS-CoV-2 infection and cytokine storm pathway inhibition: A viroinformatics study

Context: Mangosteen (Garcinia mangostana L.) is used in traditional medicine as an antibacterial, antioxidant, and anti-inflammatory. Aims: To determine the molecular mechanism and potential of garciniaxanthone derivate compounds from G. mangostana as SARS-CoV-2 antiviral and prevent cytokine storm through in silico approach. Methods: Ligand and protein samples were obtained from databases such as PubChem and Protein Databank, then drug-likeness analysis using Lipinski, Ghose, Veber, Egan, and Muege rules on SwissADME server, prediction of antiviral probability through PASSOnline server. Furthermore, molecular docking simulation with PyRx v1.0 software (Scripps Research, USA) with an academic license, identification of interactions and chemical bond positions of ligands on the target by PoseView server, 3D visualization of PyMOLv.2.5.2 software (Schrödinger, Inc., USA) with an academic license, molecular dynamics simulation for molecular stability prediction by CABS-flex v2.0 server, target prediction of antiviral candidate compounds by SwissTargetPrediction server, pathway analysis through STRING v11.5 database, and toxicity by ProTox-II server were used. Results: Garciniaxanthone C from G. mangostana was found to be a drug-like molecule with low toxicity. This can be a candidate for SARS-Cov-2 antiviral through inhibitor activity on two viral enzymes consisting of Mpro and replicase with a binding affinity value that is more negative than other garciniaxanthone derivates and is stable. Garciniaxanthone C is predicted to bind and inhibit pro-inflammatory proteins that trigger cytokine storms, such as NFKB1 and PTGS2. Conclusions: Garciniaxanthone derivative compounds from G. mangostana may be candidates for SARS-CoV-2 antiviral and preventing cytokine storm through garciniaxanthone C activity

ANALISIS IMPLEMENTASI GOOD CORPORATE GOVERNANCE PADA PT. LAZARUS CITRA INDAH

ANALISIS IMPLEMENTASI GOOD CORPORATE GOVERNANCE PADA PT. LAZARUS CITRA INDAH

Microbiology of Acid Mine Drainage: from natural attenuation to bioremediation.

International audienc

De la connaissance des microorganismes à la bioremédiation du drainage minier acide de Carnoulès

International audienc

Diversité et distribution de gènes liés à l’arsenic le long d’un gradient de pollution, dans une rivière affectée par un drainage minier acide

International audienceLes Drainages Miniers Acides (DMA), causés par l’exploitation minière, entrainent une pollutionimportante des milieux aquatiques et se caractérisent par la formation d’eaux acides très riches enéléments toxiques. Le Reigous (Gard, France) est un bon exemple de cours d’eau impacté par lesDMA, dont les teneurs en fer et arsenic sont des plus élevées au monde. Plusieurs études ont montréque l’activité bactérienne au sein du Reigous entraine rapidement une diminution importante desconcentrations en fer et arsenic dans l’eau. La compréhension de ce phénomène d’atténuationnaturelle représente donc un enjeu important pour le développement de procédés de traitement desDMA. Dans ce contexte, l’objectif de notre étude est d’améliorer nos connaissances sur l’influence deparamètres biologiques et environnementaux sur la diversité et l’activité des populationsbactériennes responsables de l’élimination de l’arsenic et du fer.Pour cela, des expérimentations en laboratoire ont été mises en œuvre dans le but de reproduire cephénomène d’atténuation naturelle observé sur le terrain. Plusieurs paramètres environnementauxont été testés tels que la température, le temps de résidence, l’oxygénation ou encore l’apport dematière organique. Nos résultats montrent que les paramètres testés influencent significativementles activités bactériennes d’oxydation du fer et de l’arsenic et par conséquent l’efficacitéd’élimination de la pollution dans l’eau. L’augmentation de la température a eu pour effetd’accélérer l’oxydation de l’arsenic (III) et du fer (II) présent dans l’eau alors que l’apport de matièreorganique a inhibé l’oxydation du fer et entrainé la formation de sédiments riche en arsenic (V).L’analyse de la diversité bactérienne, via le séquençage massif des gènes ADNr 16S, nous a permisd’identifier des populations bactériennes spécifiques en fonction des différents paramètres testés.L’analyse de ces résultats met en évidence un lien fort entre la composition bactérienne et l’efficacitéd’élimination du fer et de l’arsenic dans l’eau.En conclusion, les résultats de cette étude ouvrent de nouvelles perspectives de recherche pour ledéveloppement d’un traitement biologique des DMA riches en arsenic et en fer, prenant en comptel’influence de paramètres clés (température, nutriments) sur la composition et l’activité descommunautés bactériennes

Monitoring of bacterial communities during low temperature thermal treatment of activated sludge combining DNA phylochip and respirometry techniques

International audienceSludge reduction is one of the major challenges in biological wastewater treatment. One approach is to increase the sludge degradation yield together with the biodegradation kinetics. Among the various sludge pretreatment strategies proposed, thermal pretreatment at around 65 degrees C was described as promising. The enhancement in the biodegradation activity due to the selection of thermophilic hydrolytic bacteria was proposed, but further experiments are needed to demonstrate the specific role of these bacteria. In this study, concentrated activated sludge grown at 20 C was subjected to thermal treatment at 65 C for different periods. The originality of the work relied on a polyphasic approach based on the correlation between kinetics (chemical oxygen demand, COD; mixed liquor suspended solids, MLSS), bacterial activity (respirometry) and bacterial community structure (phylochip monitoring) in order to characterize the mechanisms involved in the thermal reduction of sludge. The bacterial activity in the aeration basin decreased to a very low level when recycling sludge was treated at 65 degrees C from 13 to 60 h, but then, started to increase after 60 h. In parallel to these fluctuations in activity, a drastic shift occurred in the bacterial community structure with the selection of thermophilic bacteria (mainly related to genera Paenibacillus and Bacillus), which are known for their specific hydrolases

Extraction of information about structural changes in a semisolid pharmaceutical formulation from near‐infrared and Raman images by multivariate curve resolution–alternating least squares and ComDim

International audienceSolid dispersions are an interesting option to improve the solubility of Class II (high permeability, low water solubility) drugs of the Biopharmaceutical Classification System without the use of organic solvents. However, structural changes (polymorphism) may be present in both active pharmaceutical ingredients (API) and excipients, which require evaluation during pharmaceutica