56 research outputs found
Evaluation of a sensitive cardiac troponin I assay as a screening test for the diagnosis of hypertrophic cardiomyopathy in cats
Background
Hypertrophic cardiomyopathy (HCM) is the most common cardiac disease in cats. However, most cats are not diagnosed until they develop congestive heart failure, arterial thromboembolism (ATE), or sudden cardiac death. Thus, an affordable screening test for early detection of HCM is desirable.
Hypothesis/Objectives
Evaluation of a sensitive cardiac troponin I (cTnI) assay as a screening test for HCM in cats and determination of a cutoff for its early detection.
Animals
One hundred sixty‐six client‐owned cats (male, n = 97) of various breeds were evaluated and classified using echocardiography as being healthy (n = 87), equivocal (n = 15), or having HCM (mild, n = 16; moderate, n = 10; severe, n = 34) or ATE (n = 4).
Methods
All cats were prospectively evaluated by echocardiography, and serum cTnI concentration was determined using the currently most sensitive assay (Siemens ADVIA Centaur TnI‐Ultra).
Results
The median cTnI concentration was significantly different between study groups (P 0.06 ng/mL remained high at 87.8% and 95.4%, respectively (AUC, 0.93; 95% CI, 0.864‐0.964).
Conclusions and clinical importance
Cardiac troponin I can be used as a sensitive and specific screening test for the diagnosis of HCM in otherwise healthy cats (cutoff, >0.06 ng/mL). However, echocardiography is needed to confirm the diagnosis
Cooling dynamics of a dilute gas of inelastic rods: a many particle simulation
We present results of simulations for a dilute gas of inelastically colliding
particles. Collisions are modelled as a stochastic process, which on average
decreases the translational energy (cooling), but allows for fluctuations in
the transfer of energy to internal vibrations. We show that these fluctuations
are strong enough to suppress inelastic collapse. This allows us to study large
systems for long times in the truely inelastic regime. During the cooling stage
we observe complex cluster dynamics, as large clusters of particles form,
collide and merge or dissolve. Typical clusters are found to survive long
enough to establish local equilibrium within a cluster, but not among different
clusters. We extend the model to include net dissipation of energy by damping
of the internal vibrations. Inelatic collapse is avoided also in this case but
in contrast to the conservative system the translational energy decays
according to the mean field scaling law, E(t)\propto t^{-2}, for asymptotically
long times.Comment: 10 pages, 12 figures, Latex; extended discussion, accepted for
publication in Phys. Rev.
A microscopic 2D lattice model of dimer granular compaction with friction
We study by Monte Carlo simulation the compaction dynamics of hard dimers in
2D under the action of gravity, subjected to vertical and horizontal shaking,
considering also the case in which a friction force acts for horizontal
displacements of the dimers. These forces are modeled by introducing effective
probabilities for all kinds of moves of the particles. We analyze the dynamics
for different values of the time during which the shaking is applied to
the system and for different intensities of the forces. It turns out that the
density evolution in time follows a stretched exponential behavior if is
not very large, while a power law tail develops for larger values of .
Moreover, in the absence of friction, a critical value exists which
signals the crossover between two different regimes: for the
asymptotic density scales with a power law of , while for
it reaches logarithmically a maximal saturation value. Such behavior smears out
when a finite friction force is present. In this situation the dynamics is
slower and lower asymptotic densities are attained. In particular, for
significant friction forces, the final density decreases linearly with the
friction coefficient. We also compare the frictionless single tap dynamics to
the sequential tapping dynamics, observing in the latter case an inverse
logarithmic behavior of the density evolution, as found in the experiments.Comment: 10 pages, 15 figures, to be published in Phys. Rev.
A model for collisions in granular gases
We propose a model for collisions between particles of a granular material
and calculate the restitution coefficients for the normal and tangential motion
as functions of the impact velocity from considerations of dissipative
viscoelastic collisions. Existing models of impact with dissipation as well as
the classical Hertz impact theory are included in the present model as special
cases. We find that the type of collision (smooth, reflecting or sticky) is
determined by the impact velocity and by the surface properties of the
colliding grains. We observe a rather nontrivial dependence of the tangential
restitution coefficient on the impact velocity.Comment: 11 pages, 2 figure
Pulse propagation in a linear and nonlinear diatomic periodic chain: effects of acoustic frequency band-gap
Metallo-cryptophanes decorated with Bis-N-heterocyclic carbene ligands: self-assembly and guest uptake into a nonporous crystalline lattice
Pd3L2 metallo-cryptophane cages with cyclotriveratrylene-type L ligands can be stabilized by use of a bis-N-heterocyclic carbene as an auxiliary cis-protecting ligand, while use of more common protecting chelating ligands such as ethylenediamine saw a Pd3L2 to Pd6L8 rearrangement occur in solution. The crystalline Pd3L2 complexes act as sponges, taking up 1,2-dichorobenzene or iodine in a single-crystal-to-single-crystal fashion despite not exhibiting conventional porosity
Streulichtmessanordnung zur Untersuchung der Oberflaechenrauheit
Scattered light measuring setup to analyze surface roughness based on the principle of angular-resolution scattered light measurement by means of one or several receiver arrays, characterized by the fact that the individual receivers of the arrays are arranged on curved supports in such a way that the geometric expansion of the individual receivers corresponds in each case to an equidistant interval within the local frequency range
Experimental study and numerical simulation of the vertical bounce of a polymer ball over a wide temperature range
The dependence to temperature of the rebound of a solid polymer ball on a rigid slab is investigated. An acrylate polymer ball is brought to a wide range of temperatures, covering its glass to rubbery transition, and let fall on a granite slab while the coe cient of restitution, duration of contact, and force history are measured experimentally. The ball fabrication is controlled in the lab, allowing the mechanical characterization of the material by classic dynamic mechanical analysis (DMA). Finite element simulations of the rebound at various temperatures are run, consider- ing the material as viscoelatic and as satisfying a WLF equation for its time-temperature superposition property. A comparison between the experiments and the simulations shows the strong link between viscoelasticity and time-temperature superposition properties of the material and the bounce characteristics of the ball
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