Letter from Adeline Manning, Albany, New York, to Anne Whitney, 1871 September 24

https://repository.wellesley.edu/whitney_correspondence/3255/thumbnail.jp

Agentes multidiana derivados de melatonina y resveratrol para la enfermedad de Alzheimer y ligandos fotomodulables del receptor nicotínico muscular

Tesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias Químicas, leída el 11-10-2019Alzheimer´s disease (AD) is a complex multifactorial illness with no effective treatment, characterized by irreversible global cognitive impairment. As only symptomatic treatment sare available with drugs acting at one single target, exploration of molecules active indifferent pathological targets is required. In this chapter, our objective was to develop new families of multitarget directed ligands (MTDLs) focused on some pathological pathways underlying AD, namely, oxidative stress and neuro inflammation. Thus, we design melatonin- and resveratrol-based MTDLs looking for activity in melatonin receptors (MT1-3Rs), monoaminoxidases (MAO-A/B), lipoxygenase-5 (LOX-5), and nuclear factor erythroid 2-related factor 2 (Nrf2). Considering the neuroprotective and neurogenic properties found in melatonin and resveratrol, we reasonably expected these activities in our MTDLs...La enfermedad de Alzheimer (EA) es un desorden multifactorial sin cura efectiva,caracterizada por un deterioro cognitivo global. Los tratamientos disponibles son sólo sintomáticos con fármacos que actúan sobre una sola diana, siendo necesarias moléculas activas por diferentes vías. En este capítulo, nuestro objetivo es desarrollar nuevas familias de ligandos multidiana (MTDL) enfocados hacia vías patológicas de la EA, concretamente, el estrés oxidativo y neuroinflamación. Así, desarrollamos MTDLs basados en melatoninay resveratrol buscando actividad en receptores de melatonina (MT1-3Rs), monoaminooxidasas (MAO-A/B), lipoxigenasa-5 (LOX-5) y el factor nuclear (erythroid-derived 2)-like 2 (Nrf2). Considerando las propiedades neuroprotectoras y neurogénicas de la melatonina y el resveratrol, esperamos razonablemente estas actividades en nuestros MTDLs...Fac. de Ciencias QuímicasTRUEunpu

Staying the return of aliens from Europe through interim measures : the case-law of the European Commission and the European Court of Human Rights

The Strasbourg case-law demonstrates a clear tendency to protect aliens through interim measures in case of imminent deportation. Usually but not uniquely those persons claim(ed) before the supervisory organs to be in a situation of extreme gravity in case of forcible return to their country of origin because they can be subject to the death penalty, life imprisonment, persecution for their political activities, deprived of medicine/adequate medical treatment. This contribution explores which typologies of cases have led the European Commission and Court to apply interim measures in those situations, as well as which rights and freedoms have been protected thereby