Bestockung und Beschattung : Erfassung an Fliessgewässern

Uferbestockungen haben neben der wichtigen Funktion der Beschattung und Abkühlung der Gewässer noch zahlreiche weitere wertvolle Funktionen. Eine schweizweite Bestandesübersicht der Bestockung bzw. Beschattung entlang der Bäche und Flüsse besteht derzeit noch nicht. Diese Informationslücke soll zukünftig mit geeigneten Methoden geschlossen werden

Fliessgewässertemperatur - zwei Modellansätze für zukünftige Prognosen

Seit Längerem steigt die globale Durchschnittstemperatur der Atmosphäre und führt damit auch in der Schweiz zu einem Anstieg der Gewässertemperaturen. Verlässliche längerfristige Prognosen hierfür sind in der Schweiz auf Bundesebene zum jetzigen Zeitpunkt nicht erstellbar. Nun wurden an der Ecole Polytechnique Fédérale de Lausanne (EPFL) zwei Modellvarianten entwickelt, um längerfristig Antworten auf Fragestellungen bezüglich Temperaturentwicklung von Fliessgewässern in der Schweiz zu ermöglichen. Parallel dazu wurde ein modulares deterministisches Modell auf der Basis des räumlich verteilten Schneedeckenmodells Alpine3D der WSL/SLF erstellt

Eukaryotic elongation factor 2 is a prognostic marker and its kinase a potential therapeutic target in HCC

Hepatocellular carcinoma is a cancer with increasing incidence and largely refractory to current anticancer drugs. Since Sorafenib, a multikinase inhibitor has shown modest efficacy in advanced hepatocellular carcinoma additional treatments are highly needed. Protein phosphorylation via kinases is an important post-translational modification to regulate cell homeostasis including proliferation and apoptosis. Therefore kinases are valuable targets in cancer therapy. To this end we performed 2D differential gel electrophoresis and mass spectrometry analysis of phosphoprotein-enriched lysates of tumor and corresponding non-tumorous liver samples to detect differentially abundant phosphoproteins to screen for novel kinases as potential drug targets. We identified 34 differentially abundant proteins in phosphoprotein enriched lysates. Expression and distribution of the candidate protein eEF2 and its phosphorylated isoform was validated immunohistochemically on 78 hepatocellular carcinoma and non-tumorous tissue samples. Validation showed that total eEF2 and phosphorylated eEF2 at threonine 56 are prognostic markers for overall survival of HCC-patients. The activity of the regulating eEF2 kinase, compared between tumor and non-tumorous tissue lysates by in vitro kinase assays, is more than four times higher in tumor tissues. Functional analyzes regarding eEF2 kinase were performed in JHH5 cells with CRISPR/Cas9 mediated eEF2 kinase knock out. Proliferation and growth is decreased in eEF2 kinase knock out cells

The emerging role of magnetic resonance imaging and multidetector computed tomography in the diagnosis of dilated cardiomyopathy

Magnetic resonance imaging and multidetector computed tomography are new imaging methods that have much to offer clinicians caring for patients with dilated cardiomyopathy. In this article we briefly describe the clinical, pathophysiological and histological aspects of dilated cardiomyopathy. Then we discuss in detail the use of both imaging methods for measurement of chamber size, global and regional function, for myocardial tissue characterisation, including myocardial viability assessment, and determination of arrhythmogenic substrate, and their emerging role in cardiac resynchronisation therapy

Inventory and evolution of glacial lakes since the Little Ice Age: Lessons from the case of Switzerland

Retreating glaciers give way to new landscapes with lakes as an important element. In this study, we combined available data on lake outlines with historical orthoimagery and glacier outlines for six time periods since the end of the Little Ice Age (LIA; ~1850). We generated a glacial lake inventory for modern times (2016) and traced the evolution of glacial lakes that formed in the deglaciated area since the LIA. In this deglaciated area, a total of 1192 lakes formed over the period of almost 170 years, 987 of them still in existence in 2016. Their total water surface in 2016 was 6.22 ± 0.25 km2. The largest lakes are > 0.4 km2 (40 ha) in size, while the majority (> 90%) are smaller than 0.01 km2. Annual increase rates in area and number peaked in 1946–1973, decreased towards the end of the 20th century, and reached a new high in the latest period 2006–2016. For a period of 43 years (1973–2016), we compared modelled overdeepenings from previous studies to actual lake genesis. For a better prioritization of formation probability, we included glacier-morphological criteria such as glacier width and visible crevassing. About 40% of the modelled overdeepened area actually got covered by lakes. The inclusion of morphological aspects clearly aided in defining a lake formation probability to be linked to each modelled overdeepening. Additional morphological variables, namely dam material and type, surface runoff, and freeboard, were compiled for a subset of larger and ice-contact lakes in 2016, constituting a basis for future hazard assessment

Design and Results of an AI-Based Forecasting of Air Pollutants for Smart Cities

This paper presents the design and the results of a novel approach to predict air pollutants in urban environments. The objective is to create an artificial intelligence (AI)-based system to support planning actors in taking effective and adequate short-term measures against unfavourable air quality situations. In general, air quality in European cities has improved over the past decades. Nevertheless, reductions of the air pollutants particulate matter (PM), nitrogen dioxide (NO2) and ground-level ozone (O3), in particular, are essential to ensure the quality of life and a healthy life in cities. To forecast these air pollutants for the next 48 hours, a sequence-to-sequence encoder-decoder model with a recurrent neural network (RNN) was implemented. The model was trained with historic in situ air pollutant measurements, traffic and meteorological data. An evaluation of the prediction results against historical data shows high accordance with in situ measurements and implicate the system’s applicability and its great potential for high quality forecasts of air pollutants in urban environments by including real time weather forecast data