Hubungan Antara Tingkat Kecemasan Dan Pola Makan Dengan Kadar Glukosa Darah Pada Pasien Diabetes Melitus Tipe 2 Di RSUD Dr. Moewardi Surakarta

Pendahuluan :Prevalensi diabetes melitus tipe 2 di RSUD Dr. Moewardi Surakarta tahun 2011 yang menjalani rawat inap sebesar 1183 orang, dan tahun 2012 sebesar 1890 orang. Sehingga mengalami kenaikan pasien dari tahun 2011-2012 sebesar 58,21%. Pada pasien diabetes melitus adanya tingkat kecemasan dapat mempengaruhi kontrol gula darah, dan jika seseorang mengalami tingkat kecemasan berat menyebabkan penurunan tenaga, rasa cepat lelah, dan sulit tidur yang dapat mempengaruhi pola makan. Pola makan adalah suatu usaha dalam pengaturan dan jenis makanan dengan maksud tertentu seperti mempertahankan kesehatan, status gizi, mencegah atau membantu kesembuhan penyakit. Tujuan :Penelitian ini bertujuan untuk mengetahui hubungan antara tingkat kecemasa dan pola makan dengan kadar glukosa pada pasien diabetes melitus tipe 2 di RSUD Dr. Moewardi Surakarta. Metode Penelitian :Jenis penelitian ini bersifat analitik dengan pendekatan cross sectional. Teknik pengambilan sample menggunakan consecutif sampling dengan jumlah sampel penelitian sebanyak 30. Tingkat kecemasan di peroleh dengan metode wawancara HRS-A. Pola makan diperoleh dengan metode FFQ. Kadar glukosa diperoleh dari data rekam medik. Analisis data dengan menggunakan korelasi pearson product moment. Hasil :Jumlah subjek dengan tingkat kecemasan berat (96,7%). Subjek yang memiliki frekuensi pola makan kurang baik (90%). Subjek yang memilikikadar glukosa darah puasa dalam kategori tinggi (93,3%), sedangkan subjek yang memiliki kadar glukosa darah 2jpp dalam kategori normal (53,3%). Kesimpulan :Tidak ada hubungan antara tingkat kecemasan dengan kadar glukosa darah pada pasien diabetes melitus tipe 2 di RSUD Dr. Moewardi Surakarta. Tidak ada hubungan antara frekuensi pola makan dengan kadar glukosa darah pada pasien diabetes melitus tipe 2 di RSUD Dr. Moewardi Surakarta

Ethnic differences in smoking intensity and COPD risk: an observational study in primary care

A.G. was in receipt of an NIHR In-Practice Fellowship while completing this work. S.H. and R.M. were supported by a Curriers’ Company Millennium Healthcare Bursary. P.S. was supported by a UK Medical Research Council fellowshi

Effect of P to A Mutation of the N-Terminal Residue Adjacent to the Rgd Motif on Rhodostomin: Importance of Dynamics in Integrin Recognition

Rhodostomin (Rho) is an RGD protein that specifically inhibits integrins. We found that Rho mutants with the P48A mutation 4.4–11.5 times more actively inhibited integrin α5β1. Structural analysis showed that they have a similar 3D conformation for the RGD loop. Docking analysis also showed no difference between their interactions with integrin α5β1. However, the backbone dynamics of RGD residues were different. The values of the R2 relaxation parameter for Rho residues R49 and D51 were 39% and 54% higher than those of the P48A mutant, which caused differences in S2, Rex, and τe. The S2 values of the P48A mutant residues R49, G50, and D51 were 29%, 14%, and 28% lower than those of Rho. The Rex values of Rho residues R49 and D51 were 0.91 s−1 and 1.42 s−1; however, no Rex was found for those of the P48A mutant. The τe values of Rho residues R49 and D51 were 9.5 and 5.1 times lower than those of P48A mutant. Mutational study showed that integrin α5β1 prefers its ligands to contain (G/A)RGD but not PRGD sequences for binding. These results demonstrate that the N-terminal proline residue adjacent to the RGD motif affect its function and dynamics, which suggests that the dynamic properties of the RGD motif may be important in Rho's interaction with integrin α5β1

Increased Resting-State Functional Connectivity in Obese Adolescents; A Magnetoencephalographic Pilot Study

BACKGROUND: Obesity is not only associated with metabolic abnormalities, but also with cognitive dysfunction and changes in the central nervous system. The present pilot study was carried out to investigate functional connectivity in obese and non-obese adolescents using magnetoencephalography (MEG). METHODOLOGY/PRINCIPAL FINDINGS: Magnetoencephalographic recordings were performed in 11 obese (mean BMI 38.8+/-4.6 kg/m(2)) and 8 lean (mean BMI 21.0+/-1.5 kg/m(2)) female adolescents (age 12-19 years) during an eyes-closed resting-state condition. From these recordings, the synchronization likelihood (SL), a common method that estimates both linear and non-linear interdependencies between MEG signals, was calculated within and between brain regions, and within standard frequency bands (delta, theta, alpha1, alpha2, beta and gamma). The obese adolescents had increased synchronization in delta (0.5-4 Hz) and beta (13-30 Hz) frequency bands compared to lean controls (P(delta total) = 0.001; P(beta total) = 0.002). CONCLUSIONS/SIGNIFICANCE: This study identified increased resting-state functional connectivity in severe obese adolescents. Considering the importance of functional coupling between brain areas for cognitive functioning, the present findings strengthen the hypothesis that obesity may have a major impact on human brain function. The cause of the observed excessive synchronization is unknown, but might be related to disturbed motivational pathways, the recently demonstrated increase in white matter volume in obese subjects or altered metabolic processes like hyperinsulinemia. The question arises whether the changes in brain structure and communication are a dynamic process due to weight gain and whether these effects are reversible or not

EEG Biofeedback as a Treatment for Substance Use Disorders: Review, Rating of Efficacy, and Recommendations for Further Research

Electroencephalographic (EEG) biofeedback has been employed in substance use disorder (SUD) over the last three decades. The SUD is a complex series of disorders with frequent comorbidities and EEG abnormalities of several types. EEG biofeedback has been employed in conjunction with other therapies and may be useful in enhancing certain outcomes of therapy. Based on published clinical studies and employing efficacy criteria adapted by the Association for Applied Psychophysiology and Biofeedback and the International Society for Neurofeedback and Research, alpha theta training—either alone for alcoholism or in combination with beta training for stimulant and mixed substance abuse and combined with residential treatment programs, is probably efficacious. Considerations of further research design taking these factors into account are discussed and descriptions of contemporary research are given

Changes in Lysozyme Flexibility upon Mutation Are Frequent, Large and Long-Ranged

We investigate changes in human c-type lysozyme flexibility upon mutation via a Distance Constraint Model, which gives a statistical mechanical treatment of network rigidity. Specifically, two dynamical metrics are tracked. Changes in flexibility index quantify differences within backbone flexibility, whereas changes in the cooperativity correlation quantify differences within pairwise mechanical couplings. Regardless of metric, the same general conclusions are drawn. That is, small structural perturbations introduced by single point mutations have a frequent and pronounced affect on lysozyme flexibility that can extend over long distances. Specifically, an appreciable change occurs in backbone flexibility for 48% of the residues, and a change in cooperativity occurs in 42% of residue pairs. The average distance from mutation to a site with a change in flexibility is 17–20 Å. Interestingly, the frequency and scale of the changes within single point mutant structures are generally larger than those observed in the hen egg white lysozyme (HEWL) ortholog, which shares 61% sequence identity with human lysozyme. For example, point mutations often lead to substantial flexibility increases within the β-subdomain, which is consistent with experimental results indicating that it is the nucleation site for amyloid formation. However, β-subdomain flexibility within the human and HEWL orthologs is more similar despite the lowered sequence identity. These results suggest compensating mutations in HEWL reestablish desired properties

Late Window Imaging Selection for Endovascular Therapy of Large Vessel Occlusion Stroke: An International Survey

Background Current stroke guidelines recommend advanced imaging (computed tomography [CT] perfusion or magnetic resonance imaging) prior to endovascular therapy (EVT) in patients with late presentation of large vessel occlusion. Adherence to guidelines may be constrained by resources or timely access to imaging. We sought to understand the factors which influence late window imaging selection for EVT candidates with large vessel occlusion. Methods We conducted an international survey from January to May 2022. The questions aimed to identify advanced imaging and treatment decisions based on access to imaging, time delays, and simulated patient scenarios. Results There were 3000 invited participants and 1506 respondents, the majority (89.6%) from comprehensive stroke centers in high‐income countries. Neurointerventionalists comprised 31.8% and noninterventionalists 68.2% of respondents. Overall, 70.7% reported routine use of advanced imaging for late EVT selection, and 63.6% reported its usage in every case. There was greater availability of advanced imaging in comprehensive stroke centers versus primary stroke centers (67.0% versus 33.7%; P<0.0001), and high‐ versus low‐middle income countries (70.5% versus 44.5%; P<0.0001). When presented with a late window patient, 41.6% would complete CT perfusion or magnetic resonance imaging prior to EVT, 25.4% would perform CT perfusion or magnetic resonance imaging prior to IVT and EVT, and 25.8% would refer to EVT without advanced imaging. If advanced imaging was not readily available, 70.1% would refer a patient to EVT based on CT in the late window. Additional time delay within 20 minutes to obtain advanced imaging was considered acceptable in 77.7% of respondents. Conclusion Current guidelines for imaging late window EVT candidates are inconsistent with imaging decisions by physicians. Most respondents consider an imaging delay of greater than 20 minutes unacceptable. Access to advanced imaging was greater in comprehensive stroke centers and high‐income countries. In the case of limited access most respondents would consider EVT based on CT only

Pengaruh experiential marketing dan word of mouth (wom) terhadap minat beli ulang produk

Penelitian ini merupakan penelitian dengan pendekatan kuantitatif. Populasi dalam penelitian ini adalah pelanggan atau pengunjung J.co yang telah melakukan pembelian lebih dari satu kali produk J.CO DONUTS & COFFEE di Plaza Mulia Mall Samarinda dengan menggunakan sampel 120 konsumen J.CO. Teknik analisis data yang digunakan regresi linier berganda. Metode pengumpulan data primer pada penelitian ini dilakukan dengan menggunakan metode survey yaitu dengan menggunakan kuesioner yang disebarkan secara langsung kepada pelanggan J.CO DONUTS & COFFEE di Kota Samarinda. Metode analisis data yang dipakai dalam penelitian ini adalah metode analisis kuantitatif dengan perhitungan menggunakan alat bantu program SPSS 20. Hasil penelitian menunjukkan: (1) Experiential marketing berpengaruh positif signifikan terhadap Minat Beli Ulang, (2) Word Of Mouth (WOM) berpengaruh positif signifikan terhadap Minat Beli Ulang