13 research outputs found
Classical Perturbation Method for the Solution of a Model of Diffusion and Reaction
In this paper, we employ perturbation method (PM) to solve nonlinear problems. As case study PM is employed to obtain approximate solutions for the nonlinear differential equation that models the diffusion and reaction in porous catalysts. We find that the square residual error (S.R.E) of our solutions is in the range and this requires only the third order approximation of PM, which shows the effectiveness of the method
Application of HPM to Solve Unsteady Squeezing Flow of a Second-Grade Fluid between Circular Plates
In this article, Homotopy Perturbation Method (HPM) is used to provide two approximate solutions to the nonlinear differential equation that describes the behaviour for the unsteady squeezing flow of a second grade fluid between circular plates. Comparing results between approximate and numerical solutions shows that our results are capable to provide an accurate solution and are extremely efficient
Clinical characteristics of patients with familial amyotrophic lateral sclerosis carrying the pathogenic GGGGCC hexanucleotide repeat expansion of C9ORF72
Cardiac Allograft Vasculopathy : A Donor or Recipient Induced Pathology?
Cardiac allograft vasculopathy (CAV) is one of the main causes of late-stage heart failure after heart transplantation. CAV is characterized by concentric luminal narrowing of the coronary arteries, but the exact pathogenesis of CAV is still not unraveled. Many researchers show evidence of an allogeneic immune response of the recipient, whereas others show contrasting results in which donor-derived cells induce an immune response against the graft. In addition, fibrosis of the neo-intima can be induced by recipient-derived circulating cells or donor-derived cells. In this review, both donor and recipient sides of the story are described to obtain better insight in the pathogenesis of CAV. Dual outcomes were found regarding the contribution of donor and recipient cells in the initiation of the immune response and the development of fibrosis during CAV. Future research could focus more on the potential synergistic interaction of donor and recipient cells leading to CAV
External validation of the INCREMENT-CPE mortality score in a carbapenem-resistant Klebsiella pneumoniae bacteraemia cohort: the prognostic significance of colistin resistance
External validation of the INCREMENT-CPE risk score (ICS) for 30-day
all-cause mortality is needed. There is also scarce information about
whether colistin resistance influences the prognosis of
carbapenem-resistant Klebsiella pneumoniae (CRKp) bacteraemia. In this
study, the ability of ICS to predict all-cause mortality in the KAPECOR
cohort was calculated using the area under the receiver operating
characteristic (AUROC) curve. The association of colistin resistance
with mortality was studied. The ICS showed an AUROC curve of 0.77 (95%
CI 0.68-0.86). A cut-off of 8 points showed 96.8% sensitivity and
50.7% specificity. Mortality of low-risk patients was not different in
those treated with monotherapy versus combination therapy. However,
mortality of high-risk patients treated with combination therapy
(37.8%) was significantly lower than in those treated with monotherapy
(68.4%) (P = 0.008). To study the prognostic significance of colistin
resistance, 83 selected cases of bacteraemia due to colistin-susceptible
CRKp were obtained from the INCREMENT cohort for comparison. Colistin
resistance could not be shown to be associated with higher mortality in
either the high-risk ICS group [adjusted odds ratio (aOR) = 1.56, 95%
CI 0.69-3.33; P = 0.29] or in 37 ICS-matched pairs (aOR = 1.38, 95% CI
0.55-3.42; P = 0.49), or in a sensitivity analysis including only KPC
isolates (aOR = 1.81, 95% CI 0.73-4.57; P = 0.20), but the precision of
estimates was low. These results validate ICS for all-cause mortality
and to optimise targeted therapy for CRKp bacteraemia. Colistin
resistance was not clearly associated with increased mortality. (C) 2019
Elsevier B.V. and International Society of Chemotherapy. All rights
reserved