MDM2 facilitates adipocyte differentiation through CRTC-mediated activation of STAT3

The ubiquitin ligase MDM2 is best known for balancing the activity of the tumor suppressor p53. We have previously shown that MDM2 is vital for adipocyte conversion through controlling Cebpd expression in a p53-independent manner. Here, we show that the proadipogenic effect of MDM2 relies on activation of the STAT family of transcription factors. Their activation was required for the cAMP-mediated induction of target genes. Interestingly, rather than influencing all cAMP-stimulated genes, inhibition of the kinases directly responsible for STAT activation, namely JAKs, or ablation of MDM2, each resulted in abolished induction of a subset of cAMP-stimulated genes, with Cebpd being among the most affected. Moreover, STATs were able to interact with the transcriptional cofactors CRTC2 and CRTC3, hitherto only reported to associate with the cAMP-responsive transcription factor CREB. Last but not least, the binding of CRTC2 to a transcriptional enhancer that interacts with the Cebpd promoter was dramatically decreased upon JAK inhibition. Our data reveal the existence of an unusual functional interplay between STATs and CREB at the onset of adipogenesis through shared CRTC cofactors

Temperature induced spin coherence dissipation in quantum dots

The temperature dependence of electron spin coherence in singly negatively charged (In,Ga)As/GaAs quantum dots is studied by time-resolved Faraday rotation. The decoherence time T2 is constant on a microsecond scale for temperatures below 20 K, for higher temperatures it shows a surprisingly sharp drop into the nanoseconds range. The decrease cannot be explained through inelastic scattering with phonons, and may be related with elastic scattering due to phonon-mediated fluctuations of the hyperfine interaction.Comment: 4 pages, 2 figure

The Standard Model from a New Phase Transition on the Lattice

Several years ago it was conjectured in the so-called Roma Approach, that gauge fixing is an essential ingredient in the lattice formulation of chiral gauge theories. In this paper we discuss in detail how the gauge-fixing approach may be realized. As in the usual (gauge invariant) lattice formulation, the continuum limit corresponds to a gaussian fixed point, that now controls both the transversal and the longitudinal modes of the gauge field. A key role is played by a new phase transition separating a conventional Higgs or Higgs-confinement phase, from a phase with broken rotational invariance. In the continuum limit we expect to find a scaling region, where the lattice correlators reproduce the euclidean correlation functions of the target (chiral) gauge theory, in the corresponding continuum gauge.Comment: 16 pages, revtex, one figure. Clarifications made, mainly in sections 3 and 6 that deal with the fermion action, to appear in Phys Rev

Effective Lagrangian for strongly coupled domain wall fermions

We derive the effective Lagrangian for mesons in lattice gauge theory with domain-wall fermions in the strong-coupling and large-N_c limits. We use the formalism of supergroups to deal with the Pauli-Villars fields, needed to regulate the contributions of the heavy fermions. We calculate the spectrum of pseudo-Goldstone bosons and show that domain wall fermions are doubled and massive in this regime. Since we take the extent and lattice spacing of the fifth dimension to infinity and zero respectively, our conclusions apply also to overlap fermions.Comment: 26 pp. RevTeX and 3 figures; corrected error in symmetry breaking scheme and added comments to discussio

A Study of the 't Hooft Model with the Overlap Dirac Operator

We present the results of an exploratory numerical study of two dimensional QCD with overlap fermions. We have performed extensive simulations for U(N_c) and SU(N_c) color groups with N_c=2, 3, 4 and coupling constants chosen to satisfy the 't Hooft condition g^2 N_c =const=4/3. We have computed the meson spectrum and decay constants, the topological susceptibility and the chiral condensate. For U(N_c) gauge groups, our results indicate that the Witten-Veneziano relation is satisfied within our statistical errors and that the chiral condensate for N_f=1 is compatible with a non-zero value. Our results exhibit universality in N_c and confirm once more the excellent chiral properties of the overlap-Dirac operator.Comment: 18 pages, 4 figure

A Perturbative Study of a General Class of Lattice Dirac Operators

A perturbative study of a general class of lattice Dirac operators is reported, which is based on an algebraic realization of the Ginsparg-Wilson relation in the form $\gamma_{5}(\gamma_{5}D)+(\gamma_{5}D)\gamma_{5} = 2a^{2k+1}(\gamma_{5}D)^{2k+2}$ where $k$ stands for a non-negative integer. The choice $k=0$ corresponds to the commonly discussed Ginsparg-Wilson relation and thus to the overlap operator. We study one-loop fermion contributions to the self-energy of the gauge field, which are related to the fermion contributions to the one-loop $\beta$ function and to the Weyl anomaly. We first explicitly demonstrate that the Ward identity is satisfied by the self-energy tensor. By performing careful analyses, we then obtain the correct self-energy tensor free of infra-red divergences, as a general consideration of the Weyl anomaly indicates. This demonstrates that our general operators give correct chiral and Weyl anomalies. In general, however, the Wilsonian effective action, which is supposed to be free of infra-red complications, is expected to be essential in the analyses of our general class of Dirac operators for dynamical gauge field.Comment: 30 pages. Some of the misprints were corrected. Phys. Rev. D (in press

Predictions and recent results in susy on the lattice

In this brief review, I summarize the current theoretical knowledge in supersymmetry on the lattice, with special emphasis on recent results in the framework of N=1 supersymmetric Yang Mills theory, Wess-Zumino model and Yang-Mills theory with extended supersymmetries.Comment: 15 pages. Invited brief review for Modern Physics Letters A. Minor change

Staggered versus overlap fermions: a study in the Schwinger model with Nf=0,1,2N_f=0,1,2

We study the scalar condensate and the topological susceptibility for a continuous range of quark masses in the Schwinger model with $N_f=0,1,2$ dynamical flavors, using both the overlap and the staggered discretization. At finite lattice spacing the differences between the two formulations become rather dramatic near the chiral limit, but they get severely reduced, at the coupling considered, after a few smearing steps.Comment: 15 pages, 7 figures, v2: 1 ref corrected, minor change