Walking Self-Portraits: Scores for Creative Exploration of Space

In this original teaching activity, participants work from a set of movement and mark-making scores to explore three dimensions of experience—memory, intervention, and collectivity—in dialogue with art, museum space, and one another

Utilizing RxNorm to Support Practical Computing Applications: Capturing Medication History in Live Electronic Health Records

RxNorm was utilized as the basis for direct-capture of medication history data in a live EHR system deployed in a large, multi-state outpatient behavioral healthcare provider in the United States serving over 75,000 distinct patients each year across 130 clinical locations. This tool incorporated auto-complete search functionality for medications and proper dosage identification assistance. The overarching goal was to understand if and how standardized terminologies like RxNorm can be used to support practical computing applications in live EHR systems. We describe the stages of implementation, approaches used to adapt RxNorm's data structure for the intended EHR application, and the challenges faced. We evaluate the implementation using a four-factor framework addressing flexibility, speed, data integrity, and medication coverage. RxNorm proved to be functional for the intended application, given appropriate adaptations to address high-speed input/output (I/O) requirements of a live EHR and the flexibility required for data entry in multiple potential clinical scenarios. Future research around search optimization for medication entry, user profiling, and linking RxNorm to drug classification schemes holds great potential for improving the user experience and utility of medication data in EHRs.Comment: Appendix (including SQL/DDL Code) available by author request. Keywords: RxNorm; Electronic Health Record; Medication History; Interoperability; Unified Medical Language System; Search Optimizatio

Patient Fall Reduction Quality Improvement Project

https://digitalcommons.psjhealth.org/summit_all/1049/thumbnail.jp

Detection and parameter estimation of binary neutron star merger remnants

Detection and parameter estimation of binary neutron star merger remnants can shed light on the physics of hot matter at supranuclear densities. Here we develop a fast, simple model that can generate gravitational waveforms, and show it can be used for both detection and parameter estimation of post-merger remnants. The model consists of three exponentially-damped sinusoids with a linear frequency-drift term. The median fitting factors between the model waveforms and numerical-relativity simulations exceed 0.90. We detect remnants at a post-merger signal-to-noise ratio of ≥7 using a Bayes-factor detection statistic with a threshold of 3000. We can constrain the primary post-merger frequency to ±^(1.4)_(1.2)% at post-merger signal-to-noise ratios of 15 with an increase in precision to ±^(0.3)_(0.2)% for post-merger signal-to-noise ratios of 50. The tidal coupling constant can be constrained to ±⁹₁₂% at post-merger signal-to-noise ratios of 15, and ±5% at post-merger signal-to-noise ratios of 50 using a hierarchical inference model

Detection and parameter estimation of binary neutron star merger remnants

Detection and parameter estimation of binary neutron star merger remnants can shed light on the physics of hot matter at supranuclear densities. Here we develop a fast, simple model that can generate gravitational waveforms, and show it can be used for both detection and parameter estimation of post-merger remnants. The model consists of three exponentially-damped sinusoids with a linear frequency-drift term. The median fitting factors between the model waveforms and numerical-relativity simulations exceed 0.90. We detect remnants at a post-merger signal-to-noise ratio of $\ge 7$ using a Bayes-factor detection statistic with a threshold of 3000. We can constrain the primary post-merger frequency to $\pm_{1.2}^{1.4}\%$ at post-merger signal-to-noise ratios of 15 with an increase in precision to $\pm_{0.2}^{0.3}\%$ for post-merger signal-to-noise ratios of 50. The tidal coupling constant can be constrained to $\pm^{9}_{12}\%$ at post-merger signal-to-noise ratios of 15, and $\pm 5\%$ at post-merger signal-to-noise ratios of 50 using a hierarchical inference model

A systematic review of interventions to improve outcomes for young adults with Type 1 diabetes.

BACKGROUND: Many young adults with Type 1 diabetes experience poor outcomes. The aim of this systematic review was to synthesize the evidence regarding the effectiveness of interventions aimed at improving clinical, behavioural or psychosocial outcomes for young adults with Type 1 diabetes. METHODS: Electronic databases were searched. Any intervention studies related to education, support, behaviour change or health service organizational change for young adults aged between 15-30 years with Type 1 diabetes were included. A narrative synthesis of all studies was undertaken due to the large degree of heterogeneity between studies. RESULTS: Eighteen studies (of a possible 1700) were selected and categorized: Health Services Delivery (n = 4), Group Education and Peer Support (n = 6), Digital Platforms (n = 4) and Diabetes Devices (n = 4). Study designs included one randomized controlled trial, three retrospective studies, seven feasibility/acceptability studies and eight studies with a pre/post design. Continuity, support, education and tailoring of interventions to young adults were the most common themes across studies. HbA1c was the most frequently measured outcome, but only 5 of 12 studies that measured it showed a significant improvement. CONCLUSION: Based on the heterogeneity among the studies, the effectiveness of interventions on clinical, behavioural and psychosocial outcomes among young adults is inconclusive. This review has highlighted a lack of high-quality, well-designed interventions, aimed at improving health outcomes for young adults with Type 1 diabetes. This article is protected by copyright. All rights reserved

A case of coexisting Warthin tumor and langerhans cell histiocytosis associated with necrosis, eosinophilic abscesses and a granulomatous reaction in intraparotid lymph nodes

We present a patient (50-year-old male) with coexisting Warthin tumor and involvement of two intraparotid lymph nodes by Langerhans cell histiocytosis associated with necrosis, eosinophilic abscesses and a granulomatous reaction. This is the second documented case of this unusual combination of histological changes in nodal Langerhans cell histiocytosis and the first case involving intraparotid lymph nodes occurring together with an ipsilateral Warthin tumor

Defining the causes of sporadic Parkinson's disease in the global Parkinson's genetics program (GP2)

The Global Parkinson's Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia

The Ubiquitin-Proteasome Reporter GFPu Does Not Accumulate in Neurons of the R6/2 Transgenic Mouse Model of Huntington's Disease

Impairment of the ubiquitin-proteasome system (UPS) has long been considered an attractive hypothesis to explain the selective dysfunction and death of neurons in polyglutamine disorders such as Huntington's disease (HD). The fact that inclusion bodies in HD mouse models and patient brains are rich in ubiquitin and proteasome components suggests that the UPS may be hindered directly or indirectly by inclusion bodies or their misfolded monomeric or oligomeric precursors. However, studies into UPS function in various polyglutamine disease models have yielded conflicting results, suggesting mutant polyglutamine tracts may exert different effects on the UPS depending on protein context, expression level, subcellular localisation and cell-type. To investigate UPS function in a well-characterised mouse model of HD, we have crossed R6/2 HD mice with transgenic UPS reporter mice expressing the GFPu construct. The GFPu construct comprises GFP fused to a constitutive degradation signal (CL-1) that promotes its rapid degradation under conditions of a healthy UPS. Using a combination of immunoblot analysis, fluorescence and immunofluorescence microscopy studies, we found that steady-state GFPu levels were not detectably different between R6/2 and non-R6/2 brain. We observed no correlation between inclusion body formation and GFPu accumulation, suggesting no direct relationship between protein aggregation and global UPS inhibition in R6/2 mice. These findings suggest that while certain branches of the UPS can be impaired by mutant polyglutamine proteins, such proteins do not necessarily cause total blockade of UPS-dependent degradation. It is therefore likely that the relationship between mutant polyglutamine proteins and the UPS is more complex than originally anticipated