Scaling Relations and Exponents in the Growth of Rough Interfaces Through Random Media

The growth of a rough interface through a random media is modelled by a continuous stochastic equation with a quenched noise. By use of the Novikov theorem we can transform the dependence of the noise on the interface height into an effective temporal correlation for different regimes of the evolution of the interface. The exponents characterizing the roughness of the interface can thus be computed by simple scaling arguments showing a good agreement with recent experiments and numerical simulations.Comment: 4 pages, RevTex, twocolumns, two figures (upon request). To appear in Europhysics Letter

Genomic Evolution of Two Acinetobacter baumannii Clinical Strains from ST-2 Clones Isolated in 2000 and 2010 (ST-2_clon_2000 and ST-2_clon_2010)

Acinetobacter baumannii is a successful nosocomial pathogen due to its ability to persist in hospital environments by acquiring mobile elements such as transposons, plasmids, and phages. In this study, we compared two genomes of A. baumannii clinical strains isolated in 2000 (ST-2_clon_2000) and 2010 (ST-2_clon_2010) from GenBank project PRJNA308422

Malnutrition as cause and consequence of sensory distorsiones

La malnutrición es una enfermedad provocada por un exceso o defecto en el consumo o aprovechamiento de los nutrientes. Habitualmente, se utiliza este término para referirse a la desnutrición, es decir, a un trastorno derivado del déficit de algún macro y o micronutrientes. Las alteraciones quimiosensoriales pueden reducir de forma importante la alimentación en el individuo, por lo que es importante verificar que el aporte de nutrientes y, de forma concreta, de algunos micronutrientes, sea suficiente, ya que alguno de ellos, como el zinc, desempeñan un papel primordial en las alteraciones del gusto y del olfato. Además, el paciente malnutrido o con una alimentación que excluya gran número de alimentos, tiene mayor riesgo de presentar déficits de dichos micronutrientes. Diversas enfermedades, tanto agudas como crónicas, se asocian a alteraciones de la percepción sensorial, y pueden llegar a afectar a más del 50% de las personas mayores de 65 años. Los efectos provocados por los fármacos y algunos tratamientos como la quimioterapia y la radioterapia, juegan también un papel muy importante en la distorsión sensorial y en la incidencia de malnutriciónMalnutrition is a pathological condition caused by an excess or deficiency in the consumption or the use of the nutrients. Usually this term refers to a lack of adequate nourishment, a disorder resulting from a deficiency of some macro and/or micronutrients. Chemo-sensory alterations can significantly reduce food choice and intake, so it is very important to verify that the supply of nutrients and specifically of some micronutrients are sufficient. Some of them, such as “zinc”, play a very important role in alterations in the sense of taste and smell. In addition malnutrition patients or a poorly-balanced diet or faulty utilization of foods have increased the risk of deficiencies in these micronutrients. Several types of diseases, both acute and chronic ones, are associated with sensory perception and can affect more than 50% of people over 65 years old. The effects caused by drugs and some treatments such as chemotherapy and radiation therapy play an important role in sensory distortion and the incidence of malnutritio

Supporting autonomy in physical education: Perception versus reality.

Esta investigación se centró, por una parte en la percepción de apoyo a la autonomía en las clases de Educación física, que tienen tanto el alumnado como el profesorado, y por otra, en la coherencia entre percepción y la realidad observada en las clases. Se aplicaron dos escalas al profesorado y al alumnado con el objeto de conocer con qué frecuencia se producen comportamientos instructivos favorables al desarrollo de la autonomía, y se observaron y grabaron en video clases impartidas por el profesorado. Los resultados muestran que la frecuencia de los comportamientos instructivos de apoyo a la autonomía durante la intervención de enseñanza es significativamente menor que la percibida por el alumnado y el profesorado. La realidad observada muestra un perfil de profesorado con gran margen de mejora en comportamientos como: calidad de la comunicación, funcionalidad de las tareas, fomento del pensamiento del alumnado, situaciones en las que el alumnado pueda expresar su opinión sobre las tareas y motivación intrínsecaThis investigation, on the one hand it focuses on students´ and teachers´ perception about autonomy support during Physical Education instruction, and on the other hand, in the coherence between perception and reality observed in the classes. Two scales were administered to determine the frequency of instructional behaviors favoring the development of autonomy, and teacher´s classes were observed and videotaped. The results show that the observed frequency of instructional behavior favoring autonomy support during classes is significantly lower than that perceived by students and teachers. The observed reality reveals a teacher profile with room for improvement in behaviors such as: communication quality, task functionality, promotion of students’ thinking, creation of situations in which students can express their opinions of the tasks, and increasing intrinsic motivationEl presente artículo forma parte del estudio realizado con la financiación del proyecto SEJ2007-672687/EDU del Ministerio de Ciencia e Innovació

Phosphomannosylation and the functional analysis of the extended Candida albicans MNN4-like gene family

We thank Luz A. López-Ramírez (Universidad de Guanajuato) for technical assistance. This work was supported by Consejo Nacional de Ciencia y Tecnología (ref. CB2011/166860; PDCPN2014-247109, and FC 2015-02-834), Universidad de Guanajuato (ref. 000025/11; 0087/13; ref. 1025/2016; Convocatoria Institucional para Fortalecer la Excelencia Académica 2015; CIFOREA 89/2016), Programa de Mejoramiento de Profesorado (ref. UGTO-PTC-261), and Red Temática Glicociencia en Salud (CONACYT-México). NG acknowledges the Wellcome Trust (086827, 075470, 101873, and 200208) and MRC Centre for Medical Mycology for funding (N006364/1). KJ was supported by a research visitor grant to Aberdeen from China Scholarship Council (CSC No. 201406055024). The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fmicb.2017.02156/full#supplementary-materialPeer reviewedPublisher PD

New host plant records for Oenomaus ortygnus (Cramer) (Lepidoptera: Lycaenidae) in Mexico

This is the first record of Oenomaus ortygnus (Cramer) damaging fruits of ilama (Annona diversifolia) and extends the butterfly distribution for three states in Mexico.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Pró-Reitoria de Pesquisa of the Universidade de São Paulo (USP

PSM-DMO: power save mode and discontinuous BLE mesh operation

The Bluetooth Low Energy (BLE) mesh profile, standardized by the Bluetooth Special Interest Group (SIG), has an increasing interest in IoT solutions. However, the standard assumes that relay and friend nodes should be continuously scanning the channel awaiting any incoming transmissions. This could be very inefficient in terms of energy consumption, particularly in application scenarios where the backbone of the mesh network cannot be powered and traffic is infrequent. Hence, we present a novel strategy, named PSM-DMO, that minimizes the scan periods and thus, significantly reduces the overall energy consumption of the mesh network. PSM-DMO is defined as a new and optional feature for the currently published BLE mesh specifications, coexists with the standard operation, and is implemented without modifying the core of the specification. The proposal, that ensures the reliability of the mesh operation, can be used in BLE sensor networks that can tolerate a certain transmission delay. PSM-DMO replaces the continuous scan by a periodic but asynchronous polling process whereby the relay and sink nodes interrogate their neighbors about the existence of data to receive or to retransmit through the network. Nodes only go into scan mode during the period of time the mesh network will be involved in the transmission and dissemination. This period is estimated by the node which is the source of data, it is announced to its neighbors and it is propagated consecutively by all the relay nodes until the destination. PSM-DMO allows a theoretical reduction in the energy consumption of relay nodes up to 99.24 %

Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells

Sorafenib is the unique accepted molecular targeted drug for the treatment of patients in advanced stage of hepatocellular carcinoma. The current study evaluated cell signaling regulation of endoplasmic reticulum (ER) stress, c-Jun-N-terminal kinase (JNK), Akt, and 5′AMP-activated protein kinase (AMPK) leading to autophagy and apoptosis induced by sorafenib. Sorafenib induced early (3–12 hr) ER stress characterized by an increase of Ser51P-eIF2α/eIF2α, C/EBP homologous protein (CHOP), IRE1α, and sXBP1, but a decrease of activating transcription factor 6 expression, overall temporally associated with the increase of Thr183,Tyr185P-JNK1/2/JNK1/2, Thr172P-AMPKα, Ser413P-Foxo3a, Thr308P-AKt/AKt and Thr32P-Foxo3a/Foxo3a ratios, and reduction of Ser2481P-mammalian target of rapamycin (mTOR)/mTOR and protein translation. This pattern was related to a transient increase of tBid, Bim EL, Beclin-1, Bcl-xL, Bcl-2, autophagy markers, and reduction of myeloid cell leukemia-1 (Mcl-1) expression. The progressive increase of CHOP expression, and reduction of Thr308P-AKt/AKt and Ser473P-AKt/AKt ratios were associated with the reduction of autophagic flux and an additional upregulation of Bim EL expression and caspase-3 activity (24 hr). Small interfering-RNA (si-RNA) assays showed that Bim, but not Bak and Bax, was involved in the induction of caspase-3 in sorafenib-treated HepG2 cells. Sorafenib increased autophagic and apoptotic markers in tumor-derived xenograft model. In conclusion, the early sorafenib-induced ER stress and regulation of JNK and AMPK-dependent signaling were related to the induction of survival autophagic process. The sustained drug treatment induced a progressive increase of ER stress and PERK-CHOP-dependent rise of Bim EL, which was associated with the shift from autophagy to apoptosis. The kinetic of Bim EL expression profile might also be related to the tight balance between AKt- and AMPK-related signaling leading to Foxo3a-dependent BIM EL upregulation.Ministerio de Economía y Competitividad BFU2016‐75352‐PInstituto de Salud Carlos III PI15/00034, PI13/ 00021, PI16/00090, PI14/01349Ministerio de Educación FPU16/05127, FPU12/01433, FPU13/01237Junta de Andalucía CTS-6264, PI-00025-2013, PI-0127-2013, PI-0198-201

Extending Qualitative Spatial Theories with Emergent Spatial Concepts: An Automated Reasoning Approach

Qualitative Spatial Reasoning is an exciting research field of the Knowledge Representation and Reasoning paradigm whose application often requires the extension, refinement or combination of existent theories (as well as the associated calculus). This paper addresses the issue of the sound spatial interpretation of formal extensions of such theories; particularly the interpretation of the extension and the desired representational features. The paper shows how to interpret certain kinds of extensions of Region Connection Calculus (RCC) theory. We also show how to rebuild the qualitative calculus of these extensions.Junta de Andalucía TIC-606