Sexual steroid hormone receptors profiles of ovarian carcinoma in Mexican women

The significance of the presence of androgen receptor (AR), estrogen receptor alpha (ER) and progesterone receptor (PR) in ovarian cancer patient survival has been a matter of numerous studies. This study was aimed to describe the expression profile of the three sexual steroid receptors in high-grade serous, endometrioid, mucinous and low-grade serous ovarian carcinoma and its association to the proliferation index in patients with primary ovarian carcinoma diagnosis, before any treatment. Eighty-one samples were obtained from the National Institute of Cancerology in Mexico City and were evaluated for the presence of AR, ER, PR and Ki67 by immunohistochemistry. The four subtypes of ovarian carcinoma displays a specific profile of the eight possible combinations of the steroid receptors with significant differences within the profile and the histological subtypes. High-grade serous carcinoma was characterized by a high frequency of both, triple-negative and AR+ ER− PR+ profiles. Endometrioid carcinoma presented a higher frequency of triple-positive profile. The presence of only AR+ profile was not observed in the endometrioid tumors. The relationship of the receptor profile with the proliferation index in the tumor epithelium shows that the expression of only ER is associated to a reduced proliferation index in endometrioid carcinoma. Steroid hormone receptor expression and co-expression could help characterize ovarian carcinoma

Online database of Medieval Iconography (8th edition)

Memoria del proyecto de innovación consistente en la la elaboración de un repertorio iconográfico compuesto de más de 150 entradas (Iconografía online); en la publicación de una revista semestral (Revista Digital de Iconografía Medieval); en la celebración de un seminario de trabajo anual; y en la recopilación recursos online de libre acceso de interés para la investigación sobre iconografía.Depto. de Historia del ArteFac. de Geografía e HistoriaFALSEsubmitte

Rediseño de aplicación de tolerancias y dimensiones para ensambles complejos: análisis de apilamiento utilizando método del peor caso y RSS

El diseño del producto tiene gran importancia en el desarrollo de productos innovadores, funcionales y manufacturables. Para lograr dichos objetivos, se vale de diversas herramientas, métodos y estudios como las tolerancias, las cuales, son el eje de todo diseño; ya que sin ellas sería muy difícil replicar los productos y más aún, ensamblarlos unos con otros. En el presente artículo se discute la metodología utilizada en la realización de un software de análisis de tolerancias, el cual, se encuentra escrito en lenguaje C. El programa realiza dos funciones principales, en primer lugar, ayuda al ingeniero a determinar ciertas tolerancias dimensionales. Las cuales, son calculadas a través de tablas establecidas (ISO 2768 y ANSI B4.1 1967, R2009) y fórmulas estadísticas (RSS). En segundo lugar, realiza análisis de tolerancias utilizando el peor caso y análisis mediante método RSS. Los resultados de ambos análisis proveen al usuario de una pauta sobre si el diseño es adecuado dadas las tolerancias previamente seleccionadas o no. Mostrando como salida final el valor de la incógnita (separación máxima, separación mínima o ambos), con lo cual, el ingeniero puede advertir la existencia de interferencias de material en etapas tempranas del diseño del producto, con lo cual, se pueden evitar altos costos en etapas futuras

Can psychopathy be prevented? Clinical, neuroimaging, and genetic data: An exploratory study

The aim of the study was to explore the relationship among brain functional activations elicited by an emotional paradigm, clinical scores (PTSD, anxiety, and depression), psychopathic traits, and genetic characteristics (5-HTTLPR) in a group of severely maltreated children compared to a healthy control group before and after the implementation of a Trauma Focused-Cognitive Behavioral Therapy. The final sample consisted of an experimental group of 14 maltreated children (mean age = 8.77 years old, S.D. = 1.83) recruited from a non-governmental shelter in Mexico City for children who had experienced child abuse and a control group of 10 children from the general population (mean age = 9.57 years old, S.D. = 1.91). Both groups were matched according to age and gender and were assessed before and after the implementation of the aforementioned therapy by means of clinical scales and an emotional paradigm that elicited brain activations which were recorded through functional magnetic resonance imaging. Genotyping of the 5-HTTLPR polymorphism was made at first assessment. A region of interest analysis showed amygdala hyperactivation during exposure to fear and anger stimuli in the maltreated children before treatment. Following therapy, a decrease in brain activity as well as a decrease in clinical symptoms were also observed. 5-HTTLPR polymorphism did not show any effect on the severity of clinical symptoms in maltreated children. Trauma-Focused Behavioral Therapy may help reorganize the brain’s processing of emotional stimuli. These observations reveal the importance of an early intervention when the mechanisms of neuroplasticity may be still recruited

Modalidad auxiliar de investigación: Acta de Evaluación de trabajo de grado en modalidad auxiliar de investigación, para obtener el título de Doctor en Cirugía Dental, en el proyecto titulado “Impacto en la calidad de vida relacionado a enfermedad periodontal en usuarios que asisten a las Unidades Comunitarias de Salud Familiar en el año 2022”

Acta finalización de proceso de grado de cincuenta estudiantes, quienes finalizaron su trabajo de investigación durante periodo de enero 2022 a diciembre 2022, lo que justifica finalización de requisito en Modalidad Auxiliar de investigación del proyecto del Centro de Investigaciones de la Facultad de Odontología de la Universidad de El Salvador, titulado: “Impacto en la calidad de vida relacionado a enfermedad periodontal en usuarios que asisten a las Unidades Comunitarias de Salud Familiar en el año 2022” para obtener el título de Doctor en Cirugía Dental de la Facultad de Odontología de la universidad de el salvador. Por tanto, se da por finalizado su trabajo de grado en modalidad auxiliar de investigación, el día trece de febrero de dos mil veintitrés

Association between administration of IL-6 antagonists and mortality among patients hospitalized for COVID-19 : a meta-analysis

IMPORTANCE Clinical trials assessing the efficacy of IL-6 antagonists in patients hospitalized for COVID-19 have variously reported benefit, no effect, and harm. OBJECTIVE To estimate the association between administration of IL-6 antagonists compared with usual care or placebo and 28-day all-cause mortality and other outcomes. DATA SOURCES Trials were identified through systematic searches of electronic databases between October 2020 and January 2021. Searches were not restricted by trial status or language. Additional trials were identified through contact with experts. STUDY SELECTION Eligible trials randomly assigned patients hospitalized for COVID-19 to a group in whom IL-6 antagonists were administered and to a group in whom neither IL-6 antagonists nor any other immunomodulators except corticosteroids were administered. Among 72 potentially eligible trials, 27 (37.5%) met study selection criteria. DATA EXTRACTION AND SYNTHESIS In this prospectivemeta-analysis, risk of biaswas assessed using the Cochrane Risk of Bias Assessment Tool. Inconsistency among trial results was assessed using the I-2 statistic. The primary analysis was an inverse variance-weighted fixed-effects meta-analysis of odds ratios (ORs) for 28-day all-cause mortality. MAIN OUTCOMES AND MEASURES The primary outcome measurewas all-cause mortality at 28 days after randomization. There were 9 secondary outcomes including progression to invasive mechanical ventilation or death and risk of secondary infection by 28 days. RESULTS A total of 10 930 patients (median age, 61 years [range of medians, 52-68 years]; 3560 [33%] were women) participating in 27 trials were included. By 28 days, there were 1407 deaths among 6449 patients randomized to IL-6 antagonists and 1158 deaths among 4481 patients randomized to usual care or placebo (summary OR, 0.86 [95% CI, 0.79-0.95]; P =.003 based on a fixed-effects meta-analysis). This corresponds to an absolute mortality risk of 22% for IL-6 antagonists compared with an assumed mortality risk of 25% for usual care or placebo. The corresponding summary ORs were 0.83 (95% CI, 0.74-0.92; P <.001) for tocilizumab and 1.08 (95% CI, 0.86-1.36; P =.52) for sarilumab. The summary ORs for the association with mortality compared with usual care or placebo in those receiving corticosteroids were 0.77 (95% CI, 0.68-0.87) for tocilizumab and 0.92 (95% CI, 0.61-1.38) for sarilumab. The ORs for the association with progression to invasive mechanical ventilation or death, compared with usual care or placebo, were 0.77 (95% CI, 0.70-0.85) for all IL-6 antagonists, 0.74 (95% CI, 0.66-0.82) for tocilizumab, and 1.00 (95% CI, 0.74-1.34) for sarilumab. Secondary infections by 28 days occurred in 21.9% of patients treated with IL-6 antagonists vs 17.6% of patients treated with usual care or placebo (OR accounting for trial sample sizes, 0.99; 95% CI, 0.85-1.16). CONCLUSIONS AND RELEVANCE In this prospectivemeta-analysis of clinical trials of patients hospitalized for COVID-19, administration of IL-6 antagonists, compared with usual care or placebo, was associated with lower 28-day all-cause mortality