Influencia del componente social en un programa de ejercicio terapéutico en la persona adulta mayor

[Resumen] Introducción. El envejecimiento es un proceso irreversible que ocurre en las tres esferas: biológica, psicológica y social. El aumento de la esperanza de vida también ha aumentado la probabilidad de sufrir cualquier tipo de discapacidad y dependencia y, por ende, también sufrir aislamiento social. Por tanto, el ejercicio terapéutico (ET) es una herramienta fundamental para mantener a las personas adultas mayores (PAM) activas, disminuyendo la probabilidad de padecer alteraciones cognitivas, mejorando la fuerza muscular, el equilibrio y las funciones cardiovasculares y pulmonares, y siendo un vínculo para unir a diferentes PAM. Objetivo. Determinar la influencia de un programa de ejercicio terapéutico grupal y de su componente social en la PAM. Metodología. Es un ensayo clínico cuasi-experimental multicéntrico de cuatro grupos. Se comparará un programa de ET grupal frente a uno individual. Tendrá una duración de doce semanas, con tres sesiones semanales que incluirán ejercicios de calentamiento, respiratorios, de coordinación y equilibrio, de fuerza muscular y aeróbicos. El programa grupal se realizará en tres centros, supervisados por fisioterapeutas y se dividirá en dos subgrupos, uno compuesto por cinco participantes y otro por tres. El programa individual también se dividirá en dos subgrupos, uno que realizará el programa en el centro y otro que lo hará desde casa, actuando como grupo control. La población de estudio serán PAM de 70 años o más, con capacidad para desplazarse independientemente y residentes en los municipios de Las Palmas de Gran Canaria, Arucas y Telde, pertenecientes a la isla de Gran Canaria. El tamaño muestral seleccionado será n=96. De cada participante, tres fisioterapeutas y dos neuropsicólogos recogerán datos sociodemográficos y variables clínicas como la función cognitiva, dolor, rangos articulares, tensión arterial, capacidad funcional y adherencia al programa, entre otros. Para comprobar si existen diferencias entre los grupos se hará uso de ANOVA de una vía (normalidad) o el test de Kruskal-Wallis (no normalidad). En caso afirmativo, se aplicarán comparaciones dos a dos a través del test de Tukey.[Abstract] Introduction. Ageing is an irreversible process that occurs in all three spheres: biological, psychological and social. The increase in life expectancy has also increased the probability of suffering from any class of disability and dependence, therefore, suffering from social isolation. On account of this, therapeutic exercise is a fundamental means to keep older adults active, decreasing the probability of suffering cognitive alterations, improving muscle strength, balance and cardiovascular and pulmonary functions; and being a link to unite different older adults. Objective. The objective of this research is to determine the influence of a therapeutic group exercise programme and its social component on older adults. Methodology. The methodology will consist of a four-group, multi-centre, quasi-experimental clinical trial. It will compare a therapeutic exercise programme group to an individual one. The duration will be twelve weeks, with three sessions per week including warm-up, breathing, coordination and balance, muscle strength and aerobic exercises. The group programme will be carried out in three centres, supervised by physiotherapists. The group will divide into two subgroups, one consisting of five participants and the other of three. With regard to the individual programme, it will be conducted by two subgroups: one will carry out the programme in the centre, while the other will do it from home, acting as a control group. The study population will be older adults of 70 years old and over who are able to move independently and reside in the municipalities of Las Palmas de Gran Canaria, Arucas and Telde, belonging to the island of Gran Canaria. The sample size selected will be n=96. From each participant, three physiotherapists and two neuropsychologists will collect socio-demographic data and clinical variables such as cognitive function, pain, joint ranges, blood pressure, functional capacity and adherence to the programme, among others. The people in charge will use one-way ANOVA (normality) or the Kruskal-Wallis test (non-normality) to test for differences between the groups. If so, two-to-two comparisons will be applied using Tukey's test.[Resumo] Introdución. O envellecemento é un proceso irreversible que se produce en tres ámbitos: biolóxico, psicolóxico e social. O aumento da esperanza de vida en aumentou a probabilidade de padecer calquera tipo de discapacidade e dependencia e, polo tanto, tamén de padecer illamento social. Por iso, o exercicio terapéutico (ET) é unha ferramenta fundamental para manter activos ás persoas adultas maiores (PAM), reducindo a probabilidade de sufrir alteracións cognitivas, mellorando a forza muscular, o equilibrio e as funcións cardiovasculares e pulmonares, e sendo un nexo para unirse a diferentes PAM. Obxetivo. Determinar a influencia dun programa de exercicio terapéutico grupal e o seu compoñente social no MAP. Metodoloxía. Trátase dun ensaio clínico cuasi-experimental multicéntrico de catro grupos. Compararáse un programa de ET en grupo cun individual. Terá unha duración de doce semanas, con tres sesións semanais que incluirán quecemento, respiración, coordinación e equilibrio, forza muscular e exercicios aeróbicos. O programa grupal realizarase en tres centros, tutelados por fisioterapeutas e dividirase en dous subgrupos, un formado por cinco participantes e outro por tres. O programa individual tamén estará dividido en dous subgrupos, un que realizará o programa no centro e outro que o fará dende a casa, actuando como grupo de control. A poboación de estudo será PAM de 70 ou máis anos, con capacidade de desprazamento independente e residente nos concellos das Palmas de Gran Canaria, Arucas e Telde, pertencentes á illa de Gran Canaria. O tamaño da mostra seleccionado será n=96. De cada participante, tres fisioterapeutas e dous neuropsicólogos recollerán datos sociodemográficos e variables clínicas como función cognitiva, dor, rangos articulares, presión arterial, capacidade funcional e adhesión ao programa, entre outras. Para comprobar se existen diferenzas entre os grupos, empregarase ANOVA unidireccional (normalidade) ou a proba de Kruskal-Wallis (non normalidade). Se é así, aplicaranse comparacións de dous en dous mediante a proba de Tukey.Traballo fin de mestrado (UDC.FCS). Asistencia e investigación sanitaria. Especialidade en investigación clínica. Curso 2021/202

CIGB-300, a synthetic peptide-based drug that targets the CK2 phosphoaceptor domain. Translational and clinical research

CK2 represents an oncology target scientifically validated. However, clinical research with inhibitors of the CK2-mediated phosphorylation event is still insufficient to recognize it as a clinically validated target. CIGB-300, an investigational peptide-based drug that targets the phosphoaceptor site, binds to a CK2 substrate array in vitro but mainly to B23/nucleophosmin in vivo. The CIGB-300 proapoptotic effect is preceded by its nucleolar localization, inhibition of the CK2-mediated phosphorylation on B23/nucleophosmin and nucleolar disassembly. Importantly, CIGB-300 shifted a protein array linked to apoptosis, ribosome biogenesis, cell proliferation, glycolisis, and cell motility in proteomic studies which helped to understand its mechanism of action. In the clinical ground, CIGB-300 has proved to be safe and well tolerated in a First-in-Human trial in women with cervical malignancies who also experienced signs of clinical benefit. In a second Phase 1 clinical trial in women with cervical cancer stage IB2/II, the MTD and DLT have been also identified in the clinical setting. Interestingly, in cervical tumors the B23/nucleophosmin protein levels were significantly reduced after CIGB-300 treatment at the nucleus compartment. In addition, expanded use of CIGB-300 in case studies has evidenced antitumor activity when administered as compassional option. Collectively, our data outline important clues on translational and clinical research from this novel peptide-based drug reinforcing its perspectives to treat cancer and paving the way to validate CK2 as a promising target in oncology.Fil: Perea, Silvio E.. Center for Genetic Engineering and Biotechnology; CubaFil: Baladron, Idania. Center for Genetic Engineering and Biotechnology; CubaFil: Garcia, Yanelda. Center for Genetic Engineering and Biotechnology; CubaFil: Perera, Yasser. Center for Genetic Engineering and Biotechnology; CubaFil: Lopez, Adlin. Center for Genetic Engineering and Biotechnology; CubaFil: Soriano, Jorge L.. Center for Genetic Engineering and Biotechnology; Cuba. General Hospital ‘‘Hermanos Ameijeiras’; CubaFil: Batista, Noyde. Center for Genetic Engineering and Biotechnology; Cuba. General Hospital ‘‘Hermanos Ameijeiras’; CubaFil: Palau, Aley. Center for Genetic Engineering and Biotechnology; Cuba. General Hospital ‘‘Hermanos Ameijeiras’; CubaFil: Hernández, Ignacio. Center for Genetic Engineering and Biotechnology; CubaFil: Farina, Hernán Gabriel. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Garcia, Idrian. Center for Genetic Engineering and Biotechnology; CubaFil: Gonzalez, Lidia. Center for Genetic Engineering and Biotechnology; CubaFil: Gil, Jeovanis. Center for Genetic Engineering and Biotechnology; CubaFil: Rodriguez, Arielis. Center for Genetic Engineering and Biotechnology; CubaFil: Solares, Margarita. Center for Genetic Engineering and Biotechnology; CubaFil: Santana, Agueda. Center for Genetic Engineering and Biotechnology; CubaFil: Cruz, Marisol. Center for Genetic Engineering and Biotechnology; CubaFil: Lopez, Matilde. Center for Genetic Engineering and Biotechnology; CubaFil: Valenzuela, Carmen. Center for Genetic Engineering and Biotechnology; CubaFil: Reyes, Osvaldo. Center for Genetic Engineering and Biotechnology; CubaFil: López Saura, Pedro A.. Center for Genetic Engineering and Biotechnology; CubaFil: González, Carlos A.. Center for Genetic Engineering and Biotechnology; CubaFil: Diaz, Alina. Center for Genetic Engineering and Biotechnology; CubaFil: Castellanos, Lila. Center for Genetic Engineering and Biotechnology; CubaFil: Sanchez, Aniel. Center for Genetic Engineering and Biotechnology; CubaFil: Betancourt, Lazaro. Center for Genetic Engineering and Biotechnology; CubaFil: Besada, Vladimir. Center for Genetic Engineering and Biotechnology; CubaFil: González, Luis J.. Center for Genetic Engineering and Biotechnology; CubaFil: Garay, Hilda. Center for Genetic Engineering and Biotechnology; CubaFil: Gómez, Roberto. Center for Genetic Engineering and Biotechnology; CubaFil: Gomez, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; ArgentinaFil: Alonso, Daniel Fernando. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Perrin, Phillipe. No especifíca;Fil: Renualt, Jean Yves. No especifíca;Fil: Sigman, Hugo. No especifíca;Fil: Herrera, Luis. Center for Genetic Engineering and Biotechnology; CubaFil: Acevedo, Boris. Center for Genetic Engineering and Biotechnology; Cub

NEOTROPICAL CARNIVORES: a data set on carnivore distribution in the Neotropics

Mammalian carnivores are considered a key group in maintaining ecological health and can indicate potential ecological integrity in landscapes where they occur. Carnivores also hold high conservation value and their habitat requirements can guide management and conservation plans. The order Carnivora has 84 species from 8 families in the Neotropical region: Canidae; Felidae; Mephitidae; Mustelidae; Otariidae; Phocidae; Procyonidae; and Ursidae. Herein, we include published and unpublished data on native terrestrial Neotropical carnivores (Canidae; Felidae; Mephitidae; Mustelidae; Procyonidae; and Ursidae). NEOTROPICAL CARNIVORES is a publicly available data set that includes 99,605 data entries from 35,511 unique georeferenced coordinates. Detection/non-detection and quantitative data were obtained from 1818 to 2018 by researchers, governmental agencies, non-governmental organizations, and private consultants. Data were collected using several methods including camera trapping, museum collections, roadkill, line transect, and opportunistic records. Literature (peer-reviewed and grey literature) from Portuguese, Spanish and English were incorporated in this compilation. Most of the data set consists of detection data entries (n = 79,343; 79.7%) but also includes non-detection data (n = 20,262; 20.3%). Of those, 43.3% also include count data (n = 43,151). The information available in NEOTROPICAL CARNIVORES will contribute to macroecological, ecological, and conservation questions in multiple spatio-temporal perspectives. As carnivores play key roles in trophic interactions, a better understanding of their distribution and habitat requirements are essential to establish conservation management plans and safeguard the future ecological health of Neotropical ecosystems. Our data paper, combined with other large-scale data sets, has great potential to clarify species distribution and related ecological processes within the Neotropics. There are no copyright restrictions and no restriction for using data from this data paper, as long as the data paper is cited as the source of the information used. We also request that users inform us of how they intend to use the data