Кредитно-інвестиційний портфель банків та його вплив на фінансування інвестиційних проектів в Україні

Автори статті досліджують проблеми формування банківського кредитно-інвестиційного портфелю в Україні. З цією метою проаналізовано стан банківського кредитно-інвестиційного портфелю в Україні та досліджено його вплив на фінансування інвестиційних проектів.Авторы статьи исследуют проблемы формирования банковского кредитно-инвестиционного портфеля в Украине. С этой целью проанализировано состояние банковского кредитно-инвестиционного портфеля в Украине и исследовано его влияние на финансирование инвестиционных проектов.The problems of building bank loan-investment portfolio in Ukraine are researched by authors.The condition of the bank portfolio state in Ukraine and its influence financial investment projects are analyzed

Contexten en begripsontwikkeling bij wiskunde 12-16.

In this article the authors present some results of research into new curricula in secondary education constructed by the Foundation for Curriculum Development (SLO). One of the main characteristics of the new curricula is that mathematics is presented in real-life problems. The underlying concept is ‘Mathematics for All’. After being tested however, the low-achieving students seem to profit less from working with real-life problems than the more able students. However, this does not mean that the present authors would plead for throwing overboard real-life problems all together

Ontology-based assistance system for control process reconfiguration of Robot-Based Applications

Due to increasing global competition, companies are challenged to make their production flexible and adaptable. This leads to a steadily increasing complexity of production systems and thus their automation and control processes. At the same time, control processes must be quickly configurable in order to be able to react to short product life cycles. Robot-based adhesive application in automotive body assembly represents one such control and automation process. In car body assembly, industrial robots are increasingly being used for gluing side panels, enabling flow operation in assembly. In the event of a functional change in the production process, such as the replacement of the adhesive to be used, all the given process interrelationships must be analysed again and reconfigured if necessary in order to ensure the quality of the bonded joint. Comprehensive data management systems that provide an overview of all the system parameters and control levers are often not available in companies, so that reconfiguration is based on experience. Correct adjustment of the process parameters thus requires the user to have precise knowledge of the complex interrelationships between the process and bonding parameters, which makes the search for solutions in the event of a process change more difficult and time-consuming. In order to master the complexity of process planning and configuration, a large number of user-supporting solutions exist in the area of product lifecycle management (PLM). However, these neither have the functionality to generate solution and optimization proposals, nor do they map the existing expert knowledge with so-called empirical values about the system behaviour. The advantages of semantic technologies including ontologies, such as their graph structure and suitability for the use of optimization algorithms, illustrate their potential as the basis of a knowledge-based assistance solution. Against this background, the aim of this paper is to develop an ontology-based knowledge management system that can consolidate existing product and process information and add expert knowledge to it. The resulting knowledge graph of the process is then examined using selected optimization algorithms (PMS, Parallel Machine Scheduling). From the analysis, configuration suggestions can be derived, which can be presented to the user with a visualisation interface. Finally, the potential of ontologies as the basis of a knowledge-based assistance system is evaluated based on given results

Taal en veiligheid: een groeiend nieuw werkveld [Language and security: a growing new field of work]

Language issues cause safety problems at work. This study presents an inventory of scientific studies in the economic sectors and assesses which level of risk management they address. Complications with language have not been investigated comprehensively across sectors as a causal factor in accidents. This leaves language related risks partially unknown, hence uncontrolled. There is lack of insight in both the nature and magnitude of this danger in healthcare, agricultural, transport and construction sectors. Healthcare is especially troublesome since patients might be victims of language related accidents due to their presence and interaction. The same may occur to members of the public in traffic accidents. In transport and agricultural sectors safety measures were taken without any analysis of language related risks. This study shows that scientific research on ‘language and safety’ is in its infancy and requires priority on the research agenda

Role of hormone cofactors in the human papillomavirus-induced carcinogenesis of the uterine cervix

peer reviewedIf human papillomavirus (HPV) is necessary for the development of (pre)neoplastic lesions of the uterine cervix, it is not sufficient. Among the cofactors involved in the malignant transformation of cells infected by HPV, sex hormones may facilitate the cervical carcinogenesis by different mechanisms, including the induction of squamous metaplasia in the transformation zone of the cervix, interactions between steroid hormones and HPV gene expression and alterations of the local immune microenvironment

A dualistic model of primary anal canal adenocarcinoma with distinct cellular origins, etiologies, inflammatory microenvironments and mutational signatures: implications for personalised medicine.

Primary adenocarcinoma of the anal canal is a rare and aggressive gastrointestinal disease with unclear pathogenesis. Because of its rarity, no clear clinical practice guideline has been defined and a targeted therapeutic armamentarium has yet to be developed. The present article aimed at addressing this information gap by in-depth characterising the anal glandular neoplasms at the histologic, immunologic, genomic and epidemiologic levels. In this multi-institutional study, we first examined the histological features displayed by each collected tumour (n = 74) and analysed their etiological relationship with human papillomavirus (HPV) infection. The intratumoural immune cell subsets (CD4, CD8, Foxp3), the expression of immune checkpoints (PD-1, PD-L1), the defect in mismatch repair proteins and the mutation analysis of multiple clinically relevant genes in the gastrointestinal cancer setting were also determined. Finally, the prognostic significance of each clinicopathological variable was assessed. Phenotypic analysis revealed two region-specific subtypes of anal canal adenocarcinoma. The significant differences in the HPV status, density of tumour-infiltrating lymphocytes, expression of immune checkpoints and mutational profile of several targetable genes further supported the separation of these latter neoplasms into two distinct entities. Importantly, anal gland/transitional-type cancers, which poorly respond to standard treatments, displayed less mutations in downstream effectors of the EGFR signalling pathway (i.e., KRAS and NRAS) and demonstrated a significantly higher expression of the immune inhibitory ligand-receptor pair PD-1/PD-L1 compared to their counterparts arising from the colorectal mucosa. Taken together, the findings reported in the present article reveal, for the first time, that glandular neoplasms of the anal canal arise by HPV-dependent or independent pathways. These etiological differences leads to both individual immune profiles and mutational landscapes that can be targeted for therapeutic benefits