Head-and-neck paragangliomas are associated with sleep-related complaints, especially in the presence of carotid body tumors

Item does not contain fulltextOBJECTIVES: The carotid body functions as a chemoreceptor. We hypothesized that head-and-neck paragangliomas (HNP) may disturb the function of these peripheral chemoreceptors and play a role in sleep-disordered breathing. DESIGN: This is a case-control study. SETTING: This study was conducted in a tertiary referral center. PARTICIPANTS AND MAIN OUTCOME MEASURES: We assessed fatigue, sleep, and exercise capacity in 74 HNP patients using three questionnaires (Epworth Sleepiness Scale, St. George Respiratory Questionnaire, and a standard clinical sleep assessment questionnaire). Outcomes were compared to those of age- and sex-matched controls. RESULTS AND CONCLUSIONS: Activity, disturbance of psychosocial function, and total score were worse compared to controls (15.4 +/- 18.5 vs. 7.2 +/- 9.9, P = 0.007; 5.3 +/- 10.5 vs. 1.2 +/- 2.6, P = 0.008; and 10.4 +/- 12.9 vs. 5.0 +/- 4.8, P = 0.006, respectively). Patients reported more daytime fatigue, concentration difficulties, and depression (51% vs. 24%, P = 0.006; 31% vs. 10%, P = 0.010; and 19% vs. 2%, P = 0.012). Waking up was reported to be less refreshing in HNP patients (53% vs. 73%, P = 0.038). Dysphonia was a predictor of symptoms, activity, disturbance of psychosocial function, and total scores. Remarkably, the presence of a carotid body tumor was an independent predictor of increased daytime sleepiness (beta = 0.287, P = 0.029). In conclusion, patients with HNP have remarkable sleep-related complaints. Especially the presence of carotid body tumors appears to be associated with increased daytime somnolence.1 juni 201

Intrinsic Statistics on Riemannian Manifolds: Basic Tools for Geometric Measurements

A preliminary appeared as INRIA RR-5093, January 2004.International audienceIn medical image analysis and high level computer vision, there is an intensive use of geometric features like orientations, lines, and geometric transformations ranging from simple ones (orientations, lines, rigid body or affine transformations, etc.) to very complex ones like curves, surfaces, or general diffeomorphic transformations. The measurement of such geometric primitives is generally noisy in real applications and we need to use statistics either to reduce the uncertainty (estimation), to compare observations, or to test hypotheses. Unfortunately, even simple geometric primitives often belong to manifolds that are not vector spaces. In previous works [1, 2], we investigated invariance requirements to build some statistical tools on transformation groups and homogeneous manifolds that avoids paradoxes. In this paper, we consider finite dimensional manifolds with a Riemannian metric as the basic structure. Based on this metric, we develop the notions of mean value and covariance matrix of a random element, normal law, Mahalanobis distance and X² law. We provide a new proof of the characterization of Riemannian centers of mass and an original gradient descent algorithm to efficiently compute them. The notion of Normal law we propose is based on the maximization of the entropy knowing the mean and covariance of the distribution. The resulting family of pdfs spans the whole range from uniform (on compact manifolds) to the point mass distribution. Moreover, we were able to provide tractable approximations (with their limits) for small variances which show that we can effectively implement and work with these definitions

A Price-Directed Approach to Real-Time Scheduling of Production Operations

A Price-Directed Approach to Real-Time Scheduling of Production Operation

A high-performance X-ray system for medical device irradiation

A new concept of X-ray irradiator for low-density products on pallets is proposed. Monte Carlo simulations are applied to predict the performance of this system. The Monte Carlo predictions reveal in good agreement with experimental data obtained using products of different densities. (C) 2007 Elsevier Ltd. All rights reserved

Realignment of a diverging electron beam: a new beam delivery system for rhodotrons

Industrially useful electron beams produced at 300 keV or more are typically generated by introducing an oscillating magnetic field near the apex of a triangular scanning horn, thus creating a diverging treatment field. Product dosing is then accomplished by conveying target material through this field. For many irradiation applications this diverging beam introduces inefficiencies in beam power utilization and dosing non-uniformity. This paper presents beam delivery systems developed by IBA for Rhodotron accelerators and, in particular, a new scan horn for delivery of a non-diverging beam.Anglai