La radio comunitaria como una esperanza de la comunicación en los territorios

Este articulo busca reflexionar en torno a los cambios producidos en los 5 años de vida de la radio comunitaria FM Esperanza en la localidad de Chañar, dpto. Gral. Belgrano, provincia de La Rioja, siendo ésta la primera experiencia de comunicación en los territorios que el INTA La Rioja acompaña desde sus inicios.EEA La RiojaFil: Chavez, Gabriela Manuela. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria La Rioja; ArgentinaFil: Villagran, Eliana Noelia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria La Rioja. Agencia de Extensión Rural Chamical; ArgentinaFil: Díaz, Gabriel. FM Esperanza; ArgentinaFil: Heredia, Fortunata. FM Esperanza; ArgentinaFil: Olivera, Nicolás. FM Esperanza; Argentin

Unraveling the Potential of miRNAs from CSCs as an Emerging Clinical Tool for Breast Cancer Diagnosis and Prognosis

This research was funded by Consejería de Salud y Familias de la Junta de Andalucía (project no. PIN-0224-2019 and PEMP-0205-2022 FEDER funds); the Ministerio de Ciencia e Innovación (project no. PID2022-140151OB-C22); the Convocatoria de Proyectos Intramurales ibs.GRANADA (project no. INTRAIBS-2020-1 and INTRAIBS-2021-09) and by the Chair “Doctors Galera-Requena in cancer stem cell research” (CMC-CTS963).Breast cancer (BC) is the most diagnosed cancer in women and the second most common cancer globally. Significant advances in BC research have led to improved early detection and effective therapies. One of the key challenges in BC is the presence of BC stem cells (BCSCs). This small subpopulation within the tumor possesses unique characteristics, including tumor-initiating capabilities, contributes to treatment resistance, and plays a role in cancer recurrence and metastasis. In recent years, microRNAs (miRNAs) have emerged as potential regulators of BCSCs, which can modulate gene expression and influence cellular processes like BCSCs' self-renewal, differentiation, and tumor-promoting pathways. Understanding the miRNA signatures of BCSCs holds great promise for improving BC diagnosis and prognosis. By targeting BCSCs and their associated miRNAs, researchers aim to develop more effective and personalized treatment strategies that may offer better outcomes for BC patients, minimizing tumor recurrence and metastasis. In conclusion, the investigation of miRNAs as regulators of BCSCs opens new directions for advancing BC research through the use of bioinformatics and the development of innovative therapeutic approaches. This review summarizes the most recent and innovative studies and clinical trials on the role of BCSCs miRNAs as potential tools for early diagnosis, prognosis, and resistance.Consejería de Salud y Familias de la Junta de Andalucía PIN-0224-2019, PEMP-0205-2022 FEDERMinisterio de Ciencia e Innovación PID2022-140151OB-C22Convocatoria de Proyectos Intramurales ibs.GRANADA INTRAIBS-2020-1, INTRAIBS-2021-09Chair “Doctors Galera-Requena in cancer stem cell research” CMC-CTS96