Synthesis of a sialic acid derivative of ristocetin aglycone as an inhibitor of influenza virus

© 2015 Institute of Chemistry, Slovak Academy of Sciences. In order to promote attachment of the ristocetin aglycone molecule to the surface of the influenza virus, the aglycone was derivatized with a hemagglutinin ligand sialic acid moiety using a click reaction. The sialoristocetin derivative exhibited somewhat lower anti-influenza virus activity than ristocetin and aglycoristocetin.status: publishe