Collaboratively Patching Linked Data

Today's Web of Data is noisy. Linked Data often needs extensive preprocessing to enable efficient use of heterogeneous resources. While consistent and valid data provides the key to efficient data processing and aggregation we are facing two main challenges: (1st) Identification of erroneous facts and tracking their origins in dynamically connected datasets is a difficult task, and (2nd) efforts in the curation of deficient facts in Linked Data are exchanged rather rarely. Since erroneous data often is duplicated and (re-)distributed by mashup applications it is not only the responsibility of a few original publishers to keep their data tidy, but progresses to be a mission for all distributers and consumers of Linked Data too. We present a new approach to expose and to reuse patches on erroneous data to enhance and to add quality information to the Web of Data. The feasibility of our approach is demonstrated by example of a collaborative game that patches statements in DBpedia data and provides notifications for relevant changes.Comment: 2nd International Workshop on Usage Analysis and the Web of Data (USEWOD2012) in the 21st International World Wide Web Conference (WWW2012), Lyon, France, April 17th, 201

Spatiotemporal Differences in Gene Expression Between Motor and Sensory Autografts and Their Effect on Femoral Nerve Regeneration in the Rat

To improve the outcome after autologous nerve grafting in the clinic, it is important to understand the limiting variables such as distinct phenotypes of motor and sensory Schwann cells. This study investigated the properties of phenotypically different autografts in a 6 mm femoral nerve defect model in the rat, where the respective femoral branches distally of the inguinal bifurcation served as homotopic, or heterotopic autografts. Axonal regeneration and target reinnervation was analyzed by gait analysis, electrophysiology, and wet muscle mass analysis. We evaluated regeneration-associated gene expression between 5 days and 10 weeks after repair, in the autografts as well as the proximal, and distal segments of the femoral nerve using qRT-PCR. Furthermore we investigated expression patterns of phenotypically pure ventral and dorsal roots. We identified highly significant differences in gene expression of a variety of regeneration-associated genes along the central – peripheral axis in healthy femoral nerves. Phenotypically mismatched grafting resulted in altered spatiotemporal expression of neurotrophic factor BDNF, GDNF receptor GFRα1, cell adhesion molecules Cadm3, Cadm4, L1CAM, and proliferation associated Ki67. Although significantly higher quadriceps muscle mass following homotopic nerve grafting was measured, we did not observe differences in gait analysis, and electrophysiological parameters between treatment paradigms. Our study provides evidence for phenotypic commitment of autologous nerve grafts after injury and gives a conclusive overview of temporal expression of several important regeneration-associated genes after repair with sensory or motor graft

Need-oriented production of meta data

In der Diplomarbeit wird anhand des Webangebots eines IT-Fachverlags untersucht, wie Metadaten für Textdokumente effizient erstellt werden können. Ziel ist es die Beschreibung und den Zugriff auf Online Beiträge zu verbessern. Es werden grundlegenden Metadatenarten beschrieben und ein Zusammenhang zwischen Auffindbarkeit von Textdokumenten und ihrer Beschreibung hergestellt. Weiterhin werden einige Möglichkeiten der Inhaltlichen Erschließung vorgestellt und einige Methoden erläutert, mit denen ihre Erstellung maschinell unterstützt werden kann. Innerhalb einer Bedarfsanalyse werden die notwendigen Metadaten identifiziert, um daraus einen Entwurf für eine verbesserte Beschreibungsstruktur (Ordnungssystem) abzuleiten. Die Arbeit enthält außerdem Vorschläge für die Erstellung der benötigten Metadaten unter den Gesichtspunkten der Qualität und Effektivität

What are central user requirements for a prosopographical database? The Index Professorum of the University Archive of Freie Universität Berlin

Im März 2021 fand am Universitätsarchiv der Freien Universität Berlin ein Co-Design Workshop zur Entwicklung eines neuen Frontends statt. Initiiert wurde der Workshop dadurch, dass am Universitätsarchiv der Freien Universität über mehrere Jahre Datenmaterial zu sämtlichen Hochschullehrer*innen und Kanzler der Freien Universität Berlin, die seit der Gründung 1948 bis einschließlich 2011 an der Hochschule tätig waren, aufbereitet wurde und dadurch eine gut strukturierte Datenbank existiert: Der Index Professorum. Bei den Daten eingeschlossen sind dabei zusätzlich Gastprofessor*innen und das Personal der Medizin von 1948 bis 2003 bzw. im Falle des Universitätsklinikums Rudolf Virchow bis zum 31.3.1995. Insgesamt beläuft sich der Stand auf 4.183 Personen und sollte damit vollständig sein. Ziel des Co-Design Workshops war es nun, zentrale Aspekte zur nutzendenzentrierten Weiterentwicklung des geplanten Online Angebotes Index Professorum des Universitätsarchivs direkt von potenziellen Nutzenden solcher Daten einzuholen.In March 2021, a co-design workshop for the development of a new front end took place at the University Archive of Freie Universität Berlin. The workshop was initiated by the fact that the university archive of Freie Universität has been processing data material on all university teachers and chancellors of Freie Universität Berlin who worked at the university from its foundation in 1948 up to and including 2011 for several years, resulting in a well-structured database: The Index Professorum. The data also includes visiting professors and medical staff from 1948 to 2003 or, in the case of the Rudolf Virchow University Hospital, until March 31, 1995. In total, the database contains 4,183 people and should therefore be complete. The aim of the co-design workshop was to identify central aspects of the user-centered development of the planned online service Index Professorum of the University Archive directly from potential users of such data

The Grasping Test Revisited: A Systematic Review of Functional Recovery in Rat Models of Median Nerve Injury

The rat median nerve model is a well-established and frequently used model for peripheral nerve injury and repair. The grasping test is the gold-standard to evaluate functional recovery in this model. However, no comprehensive review exists to summarize the course of functional recovery in regard to the lesion type. According to PRISMA-guidelines, research was performed, including the databases PubMed and Web of Science. Groups were: (1) crush injury, (2) transection with end-to-end or with (3) end-to-side coaptation and (4) isogenic or acellular allogenic grafting. Total and respective number, as well as rat strain, type of nerve defect, length of isogenic or acellular allogenic allografts, time at first signs of motor recovery (FSR) and maximal recovery grasping strength (MRGS), were evaluated. In total, 47 articles met the inclusion criteria. Group I showed earliest signs of motor recovery. Slow recovery was observable in group III and in graft length above 25 mm. Isografts recovered faster compared to other grafts. The onset and course of recovery is heavily dependent from the type of nerve injury. The grasping test should be used complementary in addition to other volitional and non-volitional tests. Repetitive examinations should be planned carefully to optimize assessment of valid and reliable data

Spatiotemporal Differences in Gene Expression Between Motor and Sensory Autografts and Their Effect on Femoral Nerve Regeneration in the Rat.

To improve the outcome after autologous nerve grafting in the clinic, it is important to understand the limiting variables such as distinct phenotypes of motor and sensory Schwann cells. This study investigated the properties of phenotypically different autografts in a 6 mm femoral nerve defect model in the rat, where the respective femoral branches distally of the inguinal bifurcation served as homotopic, or heterotopic autografts. Axonal regeneration and target reinnervation was analyzed by gait analysis, electrophysiology, and wet muscle mass analysis. We evaluated regeneration-associated gene expression between 5 days and 10 weeks after repair, in the autografts as well as the proximal, and distal segments of the femoral nerve using qRT-PCR. Furthermore we investigated expression patterns of phenotypically pure ventral and dorsal roots. We identified highly significant differences in gene expression of a variety of regeneration-associated genes along the central - peripheral axis in healthy femoral nerves. Phenotypically mismatched grafting resulted in altered spatiotemporal expression of neurotrophic factor BDNF, GDNF receptor GFRα1, cell adhesion molecules Cadm3, Cadm4, L1CAM, and proliferation associated Ki67. Although significantly higher quadriceps muscle mass following homotopic nerve grafting was measured, we did not observe differences in gait analysis, and electrophysiological parameters between treatment paradigms. Our study provides evidence for phenotypic commitment of autologous nerve grafts after injury and gives a conclusive overview of temporal expression of several important regeneration-associated genes after repair with sensory or motor graft