12,078 research outputs found
Quantum computation with trapped ions in an optical cavity
Two-qubit logical gates are proposed on the basis of two atoms trapped in a
cavity setup. Losses in the interaction by spontaneous transitions are
efficiently suppressed by employing adiabatic transitions and the Zeno effect.
Dynamical and geometrical conditional phase gates are suggested. This method
provides fidelity and a success rate of its gates very close to unity. Hence,
it is suitable for performing quantum computation.Comment: 4 pages, 5 figures, REVTEX, second part modified, typos correcte
Arrested Cracks in Nonlinear Lattice Models of Brittle Fracture
We generalize lattice models of brittle fracture to arbitrary nonlinear force
laws and study the existence of arrested semi-infinite cracks. Unlike what is
seen in the discontinuous case studied to date, the range in driving
displacement for which these arrested cracks exist is very small. Also, our
results indicate that small changes in the vicinity of the crack tip can have
an extremely large effect on arrested cracks. Finally, we briefly discuss the
possible relevance of our findings to recent experiments.Comment: submitted to PRE, Rapid Communication
Steady-State Cracks in Viscoelastic Lattice Models
We study the steady-state motion of mode III cracks propagating on a lattice
exhibiting viscoelastic dynamics. The introduction of a Kelvin viscosity
allows for a direct comparison between lattice results and continuum
treatments. Utilizing both numerical and analytical (Wiener-Hopf) techniques,
we explore this comparison as a function of the driving displacement
and the number of transverse sites . At any , the continuum theory misses
the lattice-trapping phenomenon; this is well-known, but the introduction of
introduces some new twists. More importantly, for large even at
large , the standard two-dimensional elastodynamics approach completely
misses the -dependent velocity selection, as this selection disappears
completely in the leading order naive continuum limit of the lattice problem.Comment: 27 pages, 8 figure
Nonlinear lattice model of viscoelastic Mode III fracture
We study the effect of general nonlinear force laws in viscoelastic lattice
models of fracture, focusing on the existence and stability of steady-state
Mode III cracks. We show that the hysteretic behavior at small driving is very
sensitive to the smoothness of the force law. At large driving, we find a Hopf
bifurcation to a straight crack whose velocity is periodic in time. The
frequency of the unstable bifurcating mode depends on the smoothness of the
potential, but is very close to an exact period-doubling instability. Slightly
above the onset of the instability, the system settles into a exactly
period-doubled state, presumably connected to the aforementioned bifurcation
structure. We explicitly solve for this new state and map out its
velocity-driving relation
Randomized, open-label, phase 1/2a study to determine the maximum tolerated dose of intraventricular sustained release nimodipine for subarachnoid hemorrhage (NEWTON [Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage])
BACKGROUND AND PURPOSE—: We conducted a randomized, open-label, phase 1/2a, dose-escalation study of intraventricular sustained-release nimodipine (EG-1962) to determine safety, tolerability, pharmacokinetics, and clinical effects in aneurysmal subarachnoid hemorrhage. METHODS—: Subjects with aneurysmal subarachnoid hemorrhage repaired by clipping or coiling were randomized to EG-1962 or enteral nimodipine. Subjects were World Federation of Neurological Surgeons grade 2 to 4 and had an external ventricular drain. Cohorts of 12 subjects received 100 to 1200 mg EG-1962 (9 per cohort) or enteral nimodipine (3 per cohort). The primary objective was to determine the maximum tolerated dose. RESULTS—: Fifty-four subjects in North America were randomized to EG-1962, and 18 subjects were randomized to enteral nimodipine. The maximum tolerated dose was 800 mg. One serious adverse event related to EG-1962 (400 mg) and 2 EG-1962 dose-limiting toxicities were without clinical sequelae. There was no EG-1962-related hypotension compared with 17% (3/18) with enteral nimodipine. Favorable outcome at 90 days on the extended Glasgow outcome scale occurred in 27/45 (60%, 95% confidence interval 46%–74%) EG-1962 subjects (5/9 with 100, 6/9 with 200, 7/9 with 400, 4/9 with 600, and 5/9 with 800 mg) and 5/18 (28%, 95% confidence interval 7%–48%, relative risk reduction of unfavorable outcome; 1.45, 95% confidence interval 1.04–2.03; P=0.027) enteral nimodipine subjects. EG-1962 reduced delayed cerebral ischemia (14/45 [31%] EG-1962 versus 11/18 [61%] enteral nimodipine) and rescue therapy (11/45 [24%] versus 10/18 [56%]). CONCLUSIONS—: EG-1962 was safe and tolerable to 800 mg, and in this, aneurysmal subarachnoid hemorrhage population was associated with reduced delayed cerebral ischemia and rescue therapy. Overall, the rate of favorable clinical outcome was greater in the EG-1962-treated group. CLINICAL TRIAL REGISTRATION—: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01893190
Coexistence of amplitude and frequency modulations in intracellular calcium dynamics
The complex dynamics of intracellular calcium regulates cellular responses to
information encoded in extracellular signals. Here, we study the encoding of
these external signals in the context of the Li-Rinzel model. We show that by
control of biophysical parameters the information can be encoded in amplitude
modulation, frequency modulation or mixed (AM and FM) modulation. We briefly
discuss the possible implications of this new role of information encoding for
astrocytes.Comment: 4 pages, 4 figure
BMQ
BMQ: Boston Medical Quarterly was published from 1950-1966 by the Boston University School of Medicine and the Massachusetts Memorial Hospitals. Pages 49-52, v17n2, provided courtesy of Howard Gotlieb Archival Research Center
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