The clinical and translational prospects of microneedle devices, with a focus on insulin therapy for diabetes mellitus as a case study

Microneedles have the clinical advantage of being able to deliver complex drugs across the skin in a convenient and comfortable manner yet haven’t successfully transitioned to medical practice. Diabetes mellitus is a complicated disease, which is commonly treated with multiple daily insulin injections, contributing to poor treatment adherence. Firstly, this review determines the clinical prospect of microneedles, alongside considerations that ought to be addressed before microneedle technology can be translated from bench to bedside. Thereafter, we use diabetes as a case study to consider how microneedle-based-technology may be successfully harnessed. Here, publications referring to insulin microneedles were evaluated to understand whether insertion efficiency, angle of insertion, successful dose delivery, dose adjustability, material biocompatibility and therapeutic stability are being addressed in early stage research. Moreover, over 3,000 patents from 1970-2019 were reviewed with the search term ‘“microneedle” AND “insulin”’ to understand the current status of the field. In conclusion, the reporting of early stage microneedle research demonstrated a lack of consistency relating to the translational factors addressed. Additionally, a more rational design, based on a patient-centred approach is required before microneedle-based delivery systems can be used to revolutionise the lives of people living with diabetes following regulatory approval

Proyecto de Nutrición 7ª Grado

Reconociendo las conexiones entre la salud y el rendimiento académico, así como la importancia de las prácticas escolares basadas en evidencia, el colegio SEK Ciudalcampo se asoció con Stephen Heppell, UCJC y Catergest en un proyecto de interés mutuo: establecer hábitos alimenticios saludables que tengan un efecto positivo en el aprendizaje. Un grupo de estudiantes apasionadas por el proyecto lanzó el Brain Food Group y trabajó en varias iniciativas para correr la voz sobre la alimentación saludable, específicamente al agregar 20 "alimentos para el cerebro" a nuestras dietas. Este libro de recetas fue desarrollado por ellas para que pudieran promover hábitos alimenticios saludables. ¡Esperamos que disfrutes el libro! Bajo el liderazgo del Dr. Juan Carlos Segovia de la UCJC y el Proyecto NARA, el Grupo de “Brain Food” elaboró 20 “Alimentos Cerebrales” con evidencia científica de poseer un efecto positivo en el cerebro y el aprendizaje. Basándose en la revisión de la literatura, que se puede encontrar en el apéndice, los siguientes alimentos fueron acuñados como "Alimentos para el cerebro"Fundación Felipe Segovi

Brain Food Recipes

Much is said about nutrition, and for a relatively short time we have been talking about the importance of nutrition on the brain and, therefore, on cognitive performance. A correct diet in sports performance is a priority, but will it guarantee success in competitions? Obviously not, but a wrong diet, almost certainly, will lead us to a sporting and health disaster. The same premise applies to cognitive performance. Will eating properly guarantee academic results? No, but it will facilitate better neuronal connections, more fluid information, and better oxygenation of the brain, which in the end will allow us to obtain better cognitive results. And these behaviours should be avoided in conditions where students are confined for long periods of study during exams, due to illness or any other academic activity. This is why the importance of sociodemographic factors in the dietary preferences of children at an early age is vital. We could even go further by echoing the findings of some studies that suggest that poor food choices, rich in saturated fat, salt and sugar, in preschool age are associated with reduced verbal and cognitive ability scores. Sometimes opinions emerge as to whether breakfast is appropriate or not, in which case the balance strongly shifts more toward “ adequate” breakfast. We wanted to go a bit further by analysing the different ingredients that influence the various brain functions and/or connections, for their integration into students’ daily diets. But to integrate this model it is not enough to tell the students what is right and what is not, but in this case, we have intended that they are the ones who discover them; and use them to develop different recipes so that the message reaches the rest of their classmates better. We hope that this initiative will continue over time, passing the baton to the next generations.Brain food ProjectIntertational School SEKCatergestFundación Felipe Segovi