NeXt-TDNN: Modernizing Multi-Scale Temporal Convolution Backbone for Speaker Verification

In speaker verification, ECAPA-TDNN has shown remarkable improvement by utilizing one-dimensional(1D) Res2Net block and squeeze-and-excitation(SE) module, along with multi-layer feature aggregation (MFA). Meanwhile, in vision tasks, ConvNet structures have been modernized by referring to Transformer, resulting in improved performance. In this paper, we present an improved block design for TDNN in speaker verification. Inspired by recent ConvNet structures, we replace the SE-Res2Net block in ECAPA-TDNN with a novel 1D two-step multi-scale ConvNeXt block, which we call TS-ConvNeXt. The TS-ConvNeXt block is constructed using two separated sub-modules: a temporal multi-scale convolution (MSC) and a frame-wise feed-forward network (FFN). This two-step design allows for flexible capturing of inter-frame and intra-frame contexts. Additionally, we introduce global response normalization (GRN) for the FFN modules to enable more selective feature propagation, similar to the SE module in ECAPA-TDNN. Experimental results demonstrate that NeXt-TDNN, with a modernized backbone block, significantly improved performance in speaker verification tasks while reducing parameter size and inference time. We have released our code for future studies.Comment: Accepted by ICASSP 202

Real-Time Test-Bed System Development Using Power Hardware-in-the-Loop (PHIL) Simulation Technique for Reliability Test of DC Nano Grid

Since various power sources such as renewable energy and energy storage systems (ESSs) are connected to the DC grid, the reliability of the grid system is significant. However, the configuration of an actual DC grids for testing the reliability of the grid system is inconvenient, expensive and dangerous. In this paper, a test-bed system made up of a 20-kW DC nano grid and a control algorithm considering an external grid based on Power Hardware-in-the-Loop (PHIL) simulation are proposed to demonstrate the reliability of the DC grid. Using the PHIL simulation technique, target grids can be safely implemented with laboratory-level instruments and simulated by real-time simulators, which emulates grid operations that are similar to the actual grid. In addition, using the proposed control algorithm, the operations of grid-connected converters are demonstrated according to the grid-connected or islanding modes. Finally, the reliability of the simulated DC nano grid and the effectiveness of the grid-connected converter are verified using the PHIL simulation system with 3-kW prototype converters

Small-sized flat-tip CNT emitters for miniaturized X-ray tubes

Small tip-type CNT emitters with the diameter of 0.8 mm were fabricated for miniaturized X-ray tubes. The CNT emitters were prepared by dropping CNTs and silver nanoparticles on a flat surface of a W metal tip followed by annealing at 800 • C for 2 h under vacuum. The CNT emitters exhibit good field emission properties with the threshold electric field of 1.15 V/μm and the field enhancement factor of 12,050. CNTs were well attached to a flat W tip surface without coating on the side plane of the tip, and thus beam divergence could be minimized. Consequently, a miniaturized X-ray tube with the inner diameter of 5 mm was successfully demonstrated using the tip-type CNT emitter. Nanostructured materials are widely used for electron emitters because of their good field-emission properties • C can induce a serious heating of the small X-ray tube. High operating temperature of miniaturized X-ray tubes limits the applications of the tubes, for example, to brachytherapy. Consequently, a cooling device is required for the operation, but the cooling device increases the size of the miniaturized X-ray tube. In this sense, CNT emitters are proper electron sources because electrons are generated through field emission, and hence the cold emission process does not increase the temperature of the X-ray tube. In addition, CNT emitters are also promising electron emitters for microfocus X-ray tube

Small-Sized Flat-Tip CNT Emitters for Miniaturized X-Ray Tubes

Small tip-type CNT emitters with the diameter of 0.8 mm were fabricated for miniaturized X-ray tubes. The CNT emitters were prepared by dropping CNTs and silver nanoparticles on a flat surface of a W metal tip followed by annealing at 800°C for 2 h under vacuum. The CNT emitters exhibit good field emission properties with the threshold electric field of 1.15 V/μm and the field enhancement factor of 12,050. CNTs were well attached to a flat W tip surface without coating on the side plane of the tip, and thus beam divergence could be minimized. Consequently, a miniaturized X-ray tube with the inner diameter of 5 mm was successfully demonstrated using the tip-type CNT emitter

Effects of exercise on obesity-induced mitochondrial dysfunction in skeletal muscle

Obesity is known to induce inhibition of glucose uptake, reduction of lipid metabolism, and progressive loss of skeletal muscle function, which are all as- sociated with mitochondrial dysfunction in skeletal muscle. Mitochondria are dy- namic organelles that regulate cellular metabolism and bioenergetics, including ATP production via oxidative phosphorylation. Due to these critical roles of mitochon- dria, mitochondrial dysfunction results in various diseases such as obesity and type 2 diabetes. Obesity is associated with impairment of mitochondrial function (e.g., decrease in O2 respiration and increase in oxidative stress) in skeletal muscle. The bal- ance between mitochondrial fusion and fission is critical to maintain mitochondrial homeostasis in skeletal muscle. Obesity impairs mitochondrial dynamics, leading to an unbalance between fusion and fission by favorably shifting fission or reducing fusion proteins. Mitophagy is the catabolic process of damaged or unnecessary mito- chondria. Obesity reduces mitochondrial biogenesis in skeletal muscle and increases accumulation of dysfunctional cellular organelles, suggesting that mitophagy does not work properly in obesity. Mitochondrial dysfunction and oxidative stress are reported to trigger apoptosis, and mitochondrial apoptosis is induced by obesity in skeletal muscle. It is well known that exercise is the most effective intervention to protect against obesity. Although the cellular and molecular mechanisms by which exercise protects against obesity-induced mitochondrial dysfunction in skeletal mus- cle are not clearly elucidated, exercise training attenuates mitochondrial dysfunction, allows mitochondria to maintain the balance between mitochondrial dynamics and mitophagy, and reduces apoptotic signaling in obese skeletal muscle

The Hair Growth-Promoting Effect of Rumex japonicus

Rumex japonicus Houtt. is traditionally used as a medicinal plant to treat patients suffering from skin disease in Korea. However, the beneficial effect of Rumex japonicus Houtt. on hair growth has not been thoroughly examined. Therefore, the present study aims to investigate the hair growth-promoting effect of Rumex japonicus (RJ) Houtt. root extract using human dermal papilla cells (DPCs), HaCaT cells, and C57BL/6 mice model. RJ induced antiapoptotic and proliferative effects on DPCs and HaCaT cells by increasing Bcl-2/Bax ratio and activating cellular proliferation-related proteins, ERK and Akt. RJ also increased β-catenin via the inhibition of GSK-3β. In C57BL/6 mice model, RJ promoted the anagen induction and maintained its period. Immunohistochemistry analysis demonstrated that RJ upregulated Ki-67 and β-catenin expressions, suggesting that the hair growth effect of RJ may be mediated through the reinforcement of hair cell proliferation. These results provided important insights for the possible mechanism of action of RJ and its potential as therapeutic agent to promote hair growth

Cardiac arrest from acute hyperkalemia during liver surgery -A case report-

We experienced a case of sudden onset of hyperkalemia during liver lobectomy and this was followed by ventricular tachycardia and cardiac arrest. The main cause of this fatality is assumed to be the wide range of surgical manipulation that induced reduced hepatic blood flow and ischemic necrosis of the hepatic cells. We report here on this case and we review the relevant medical literature

A novel bispecific antibody dual-targeting approach for enhanced neutralization against fast-evolving SARS-CoV-2 variants

IntroductionThe emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has caused unprecedented health and socioeconomic crises, necessitating the immediate development of highly effective neutralizing antibodies. Despite recent advancements in anti-SARS-CoV-2 receptor-binding domain (RBD)-specific monoclonal antibodies (mAbs) derived from convalescent patient samples, their efficacy against emerging variants has been limited. In this study, we present a novel dual-targeting strategy using bispecific antibodies (bsAbs) that specifically recognize both the SARS-CoV-2 RBD and fusion peptide (FP), crucial domains for viral attachment to the host cell membrane and fusion in SARS-CoV-2 infection. MethodsUsing phage display technology, we rapidly isolated FP-specific mAbs from an established human recombinant antibody library, identifying K107.1 with a nanomolar affinity for SARS-CoV-2 FP. Furthermore, we generated K203.A, a new bsAb built in immunoglobulin G4-(single-chain variable fragment)2 forms and demonstrating a high manufacturing yield and nanomolar affinity to both the RBD and FP, by fusing K102.1, our previously reported RBD-specific mAb, with K107.1. ResultsOur comprehensive in vitro functional analyses revealed that the K203.A bsAb significantly outperformed the parental RBD-specific mAb in terms of neutralization efficacy against SARS-CoV-2 variants. Furthermore, intravenous monotherapy with K203.A demonstrated potent in vivo neutralizing activity without significant in vivo toxicity in a mouse model infected with a SARS-CoV-2 variant. ConclusionThese findings present a novel bsAb dual-targeting strategy, directed at SARS-CoV-2 RBD and FP, as an effective approach for rapid development and management against continuously evolving SARS-CoV-2 variants