5,790 research outputs found
On the Slow Roll Expansion for Brane Inflation
One possibility for identifying the inflaton in the framework of string
theory is that it is a -brane modulus. This option involves a specific,
non-canonical form of the kinetic energy -- the Dirac-Born-Infeld action. This
note investigates the applicability of the slow roll approximation in
inflationary models of this type. To this end the slow roll expansion of
Liddle, Parsons and Barrow is derived for the case of the DBI action. The
resulting slow roll conditions augment the standard ones valid in the case of
canonical kinetic terms. It is also shown that in DBI models inflation does not
require that the potential dominate the energy density.Comment: References adde
A ring-shaped conduit connects the mother cell and forespore during sporulation in Bacillus subtilis
During spore formation in Bacillus subtilis a transenvelope complex is assembled across the double membrane that separates the mother cell and forespore. This complex (called the "A-Q complex") is required to maintain forespore development and is composed of proteins with remote homology to components of type II, III, and IV secretion systems found in Gram-negative bacteria. Here, we show that one of these proteins, SpoIIIAG, which has remote homology to ring-forming proteins found in type III secretion systems, assembles into an oligomeric ring in the periplasmic-like space between the two membranes. Three-dimensional reconstruction of images generated by cryo-electron microscopy indicates that the SpoIIIAG ring has a cup-and-saucer architecture with a 6-nm central pore. Structural modeling of SpoIIIAG generated a 24-member ring with dimensions similar to those of the EM-derived saucer. Point mutations in the predicted oligomeric interface disrupted ring formation in vitro and impaired forespore gene expression and efficient spore formation in vivo. Taken together, our data provide strong support for the model in which the A-Q transenvelope complex contains a conduit that connects the mother cell and forespore. We propose that a set of stacked rings spans the intermembrane space, as has been found for type III secretion systems
Duality Cascade in Brane Inflation
We show that brane inflation is very sensitive to tiny sharp features in
extra dimensions, including those in the potential and in the warp factor. This
can show up as observational signatures in the power spectrum and/or
non-Gaussianities of the cosmic microwave background radiation (CMBR). One
general example of such sharp features is a succession of small steps in a
warped throat, caused by Seiberg duality cascade using gauge/gravity duality.
We study the cosmological observational consequences of these steps in brane
inflation. Since the steps come in a series, the prediction of other steps and
their properties can be tested by future data and analysis. It is also possible
that the steps are too close to be resolved in the power spectrum, in which
case they may show up only in the non-Gaussianity of the CMB temperature
fluctuations and/or EE polarization. We study two cases. In the slow-roll
scenario where steps appear in the inflaton potential, the sensitivity of brane
inflation to the height and width of the steps is increased by several orders
of magnitude comparing to that in previously studied large field models. In the
IR DBI scenario where steps appear in the warp factor, we find that the
glitches in the power spectrum caused by these sharp features are generally
small or even unobservable, but associated distinctive non-Gaussianity can be
large. Together with its large negative running of the power spectrum index,
this scenario clearly illustrates how rich and different a brane inflationary
scenario can be when compared to generic slow-roll inflation. Such distinctive
stringy features may provide a powerful probe of superstring theory.Comment: Corrections in Eq.(5.47), Eq (5.48), Eq(5.49) and Fig
On Power Law Inflation in DBI Models
Inflationary models in string theory which identify the inflaton with an open
string modulus lead to effective field theories with non-canonical kinetic
terms: Dirac-Born-Infeld scalar field theories. In the case of a -brane
moving in an AdS throat with a quadratic scalar field potential DBI kinetic
terms allow a novel realization of power law inflation. This note adresses the
question of whether this behaviour is special to this particular choice of
throat geometry and potential. The answer is that for any throat geometry one
can explicitly find a potential which leads to power law inflation. This
generalizes the well known fact that an exponential potential gives power law
inflation in the case of canonical kinetic terms.Comment: References and comments adde
Comparing Brane Inflation to WMAP
We compare the simplest realistic brane inflationary model to recent
cosmological data, including WMAP 3-year cosmic microwave background (CMB)
results, Sloan Digital Sky Survey luminous red galaxies (SDSS LRG) power
spectrum data and Supernovae Legacy Survey (SNLS) Type 1a supernovae distance
measures. Here, the inflaton is simply the position of a -brane which is
moving towards a -brane sitting at the bottom of a throat (a warped,
deformed conifold) in the flux compactified bulk in Type IIB string theory. The
analysis includes both the usual slow-roll scenario and the Dirac-Born-Infeld
scenario of slow but relativistic rolling. Requiring that the throat is inside
the bulk greatly restricts the allowed parameter space. We discuss possible
scenarios in which large tensor mode and/or non-Gaussianity may emerge. Here,
the properties of a large tensor mode deviate from that in the usual slow-roll
scenario, providing a possible stringy signature. Overall, within the brane
inflationary scenario, the cosmological data is providing information about the
properties of the compactification of the extra dimensions.Comment: 45 pages 11 figure
Nonnegative principal component analysis for mass spectral serum profiles and biomarker discovery
<p>Abstract</p> <p>Background</p> <p>As a novel cancer diagnostic paradigm, mass spectroscopic serum proteomic pattern diagnostics was reported superior to the conventional serologic cancer biomarkers. However, its clinical use is not fully validated yet. An important factor to prevent this young technology to become a mainstream cancer diagnostic paradigm is that robustly identifying cancer molecular patterns from high-dimensional protein expression data is still a challenge in machine learning and oncology research. As a well-established dimension reduction technique, PCA is widely integrated in pattern recognition analysis to discover cancer molecular patterns. However, its global feature selection mechanism prevents it from capturing local features. This may lead to difficulty in achieving high-performance proteomic pattern discovery, because only features interpreting global data behavior are used to train a learning machine.</p> <p>Methods</p> <p>In this study, we develop a nonnegative principal component analysis algorithm and present a nonnegative principal component analysis based support vector machine algorithm with sparse coding to conduct a high-performance proteomic pattern classification. Moreover, we also propose a nonnegative principal component analysis based filter-wrapper biomarker capturing algorithm for mass spectral serum profiles.</p> <p>Results</p> <p>We demonstrate the superiority of the proposed algorithm by comparison with six peer algorithms on four benchmark datasets. Moreover, we illustrate that nonnegative principal component analysis can be effectively used to capture meaningful biomarkers.</p> <p>Conclusion</p> <p>Our analysis suggests that nonnegative principal component analysis effectively conduct local feature selection for mass spectral profiles and contribute to improving sensitivities and specificities in the following classification, and meaningful biomarker discovery.</p
Final results of the EDELWEISS-II WIMP search using a 4-kg array of cryogenic germanium detectors with interleaved electrodes
The EDELWEISS-II collaboration has completed a direct search for WIMP dark
matter with an array of ten 400-g cryogenic germanium detectors in operation at
the Laboratoire Souterrain de Modane. The combined use of thermal phonon
sensors and charge collection electrodes with an interleaved geometry enables
the efficient rejection of gamma-induced radioactivity as well as near-surface
interactions. A total effective exposure of 384 kg.d has been achieved, mostly
coming from fourteen months of continuous operation. Five nuclear recoil
candidates are observed above 20 keV, while the estimated background is 3.0
events. The result is interpreted in terms of limits on the cross-section of
spin-independent interactions of WIMPs and nucleons. A cross-section of
4.4x10^-8 pb is excluded at 90%CL for a WIMP mass of 85 GeV. New constraints
are also set on models where the WIMP-nucleon scattering is inelastic.Comment: 23 pages, 5 figures; matches published versio
A search for low-mass WIMPs with EDELWEISS-II heat-and-ionization detectors
We report on a search for low-energy (E < 20 keV) WIMP-induced nuclear
recoils using data collected in 2009 - 2010 by EDELWEISS from four germanium
detectors equipped with thermal sensors and an electrode design (ID) which
allows to efficiently reject several sources of background. The data indicate
no evidence for an exponential distribution of low-energy nuclear recoils that
could be attributed to WIMP elastic scattering after an exposure of 113 kg.d.
For WIMPs of mass 10 GeV, the observation of one event in the WIMP search
region results in a 90% CL limit of 1.0x10^-5 pb on the spin-independent
WIMP-nucleon scattering cross-section, which constrains the parameter space
associated with the findings reported by the CoGeNT, DAMA and CRESST
experiments.Comment: PRD rapid communication accepte
Jets as a Probe of Dense Matter at RHIC
Jet quenching in the matter created in high energy nucleus-nucleus collisions
provides a tomographic tool to probe the medium properties. Recent experimental
results on jet production at the Relativistic Heavy-Ion Collider (RHIC) are
reviewed. Jet properties in p+p and d+Au collisions have been measured,
establishing the baseline for studying jet modification in heavy-ion
collisions. Current progress on detailed studies of high transverse momentum
production in Au+Au collisions is discussed, with an emphasis on dihadron
correlation measurements.Comment: 8 pages, 9 figures. Plenary talk given at 17th International
Conference on Ultra Relativistic Nucleus-Nucleus Collisions (Quark Matter
2004), Oakland, California, 11-17 Jan 2004. Submitted to J.Phys.
Size-Dependent Transition to High-Dimensional Chaotic Dynamics in a Two-Dimensional Excitable Medium
The spatiotemporal dynamics of an excitable medium with multiple spiral
defects is shown to vary smoothly with system size from short-lived transients
for small systems to extensive chaos for large systems. A comparison of the
Lyapunov dimension density with the average spiral defect density suggests an
average dimension per spiral defect varying between three and seven. We discuss
some implications of these results for experimental studies of excitable media.Comment: 5 pages, Latex, 4 figure
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