7,446 research outputs found
The oxidation of ascorbic acid and its reduction in vitro and in vivo
The outstanding chemical property of ascorbic acid (vitamin C) is that it is a reducing agent. The suggestion is obvious that its physiological function may be associated with this property, and, if it is oxidized reversibly, with its behavior in an oxidation-reduction system. It is desirable therefore to know the oxidation-reduction potential of ascorbic acid
Propulsion simulation for magnetically suspended wind tunnel models
The feasibility of simulating propulsion-induced aerodynamic effects on scaled aircraft models in wind tunnels employing Magnetic Suspension and Balance Systems. The investigation concerned itself with techniques of generating exhaust jets of appropriate characteristics. The objectives were to: (1) define thrust and mass flow requirements of jets; (2) evaluate techniques for generating propulsive gas within volume limitations imposed by magnetically-suspended models; (3) conduct simple diagnostic experiments for techniques involving new concepts; and (4) recommend experiments for demonstration of propulsion simulation techniques. Various techniques of generating exhaust jets of appropriate characteristics were evaluated on scaled aircraft models in wind tunnels with MSBS. Four concepts of remotely-operated propulsion simulators were examined. Three conceptual designs involving innovative adaptation of convenient technologies (compressed gas cylinders, liquid, and solid propellants) were developed. The fourth innovative concept, namely, the laser-assisted thruster, which can potentially simulate both inlet and exhaust flows, was found to require very high power levels for small thrust levels
AlGaInN laser diode technology for GHz high-speed visible light communication through plastic optical fiber and water
AlGaInN ridge waveguide laser diodes are fabricated to achieve single-mode operation with optical powers up to 100 mW at ∼420  nm∼420  nm for visible free-space, underwater, and plastic optical fiber communication. We report high-frequency operation of AlGaInN laser diodes with data transmission up to 2.5 GHz for free-space and underwater communication and up to 1.38 GHz through 10 m of plastic optical fiber
Studies of multiple stellar systems - IV. The triple-lined spectroscopic system Gliese 644
We present a radial-velocity study of the triple-lined system Gliese 644 and
derive spectroscopic elements for the inner and outer orbits with periods of
2.9655 and 627 days. We also utilize old visual data, as well as modern speckle
and adaptive optics observations, to derive a new astrometric solution for the
outer orbit. These two orbits together allow us to derive masses for each of
the three components in the system: M_A = 0.410 +/- 0.028 (6.9%), M_Ba = 0.336
+/- 0.016 (4.7%), and $M_Bb = 0.304 +/- 0.014 (4.7%) M_solar. We suggest that
the relative inclination of the two orbits is very small. Our individual masses
and spectroscopic light ratios for the three M stars in the Gliese 644 system
provide three points for the mass-luminosity relation near the bottom of the
Main Sequence, where the relation is poorly determined. These three points
agree well with theoretical models for solar metallicity and an age of 5 Gyr.
Our radial velocities for Gliese 643 and vB 8, two common-proper-motion
companions of Gliese 644, support the interpretation that all five M stars are
moving together in a physically bound group. We discuss possible scenarios for
the formation and evolution of this configuration, such as the formation of all
five stars in a sequence of fragmentation events leading directly to the
hierarchical configuration now observed, versus formation in a small N cluster
with subsequent dynamical evolution into the present hierarchical
configuration.Comment: 17 pages, 9 figures, Accepted for publication in MNRA
Activation of G proteins by GIV-GEF is a pivot point for insulin resistance and sensitivity.
Insulin resistance (IR) is a metabolic disorder characterized by impaired insulin signaling and cellular glucose uptake. The current paradigm for insulin signaling centers upon the insulin receptor (InsR) and its substrate IRS1; the latter is believed to be the sole conduit for postreceptor signaling. Here we challenge that paradigm and show that GIV/Girdin, a guanidine exchange factor (GEF) for the trimeric G protein Gαi, is another major hierarchical conduit for the metabolic insulin response. By virtue of its ability to directly bind InsR, IRS1, and phosphoinositide 3-kinase, GIV serves as a key hub in the immediate postreceptor level, which coordinately enhances the metabolic insulin response and glucose uptake in myotubes via its GEF function. Site-directed mutagenesis or phosphoinhibition of GIV-GEF by the fatty acid/protein kinase C-theta pathway triggers IR. Insulin sensitizers reverse phosphoinhibition of GIV and reinstate insulin sensitivity. We also provide evidence for such reversible regulation of GIV-GEF in skeletal muscles from patients with IR. Thus GIV is an essential upstream component that couples InsR to G-protein signaling to enhance the metabolic insulin response, and impairment of such coupling triggers IR. We also provide evidence that GIV-GEF serves as therapeutic target for exogenous manipulation of physiological insulin response and reversal of IR in skeletal muscles
Measurements of the Diffuse Ultraviolet Background and the Terrestrial Airglow with the Space Telescope Imaging Spectrograph
Far-UV observations in and near the Hubble Deep Fields demonstrate that the
Space Telescope Imaging Spectrograph (STIS) can potentially obtain unique and
precise measurements of the diffuse far-ultraviolet background. Although STIS
is not the ideal instrument for such measurements, high-resolution images allow
Galactic and extragalactic objects to be masked to very faint magnitudes, thus
ensuring a measurement of the truly diffuse UV signal. The programs we have
analyzed were not designed for this scientific purpose, but would be sufficient
to obtain a very sensitive measurement if it were not for a weak but
larger-than-expected signal from airglow in the STIS 1450-1900 A bandpass. Our
analysis shows that STIS far-UV crystal quartz observations taken near the limb
during orbital day can detect a faint airglow signal, most likely from NI\1493,
that is comparable to the dark rate and inseparable from the far-UV background.
Discarding all but the night data from these datasets gives a diffuse
far-ultraviolet background measurement of 501 +/- 103 ph/cm2/sec/ster/A, along
a line of sight with very low Galactic neutral hydrogen column (N_HI = 1.5E20
cm-2) and extinction (E(B-V)=0.01 mag). This result is in good agreement with
earlier measurements of the far-UV background, and should not include any
significant contribution from airglow. We present our findings as a warning to
other groups who may use the STIS far-UV camera to observe faint extended
targets, and to demonstrate how this measurement may be properly obtained with
STIS.Comment: 7 pages, Latex. 4 figures. Uses corrected version of emulateapj.sty
and apjfonts.sty (included). Accepted for publication in A
Rlpy: A Value-Function-Based Reinforcement Learning Framework for Education and Research
RLPy is an object-oriented reinforcement learning software package with a focus on valuefunction-based methods using linear function approximation and discrete actions. The framework was designed for both educational and research purposes. It provides a rich library of fine-grained, easily exchangeable components for learning agents (e.g., policies or representations of value functions), facilitating recently increased specialization in reinforcement learning. RLPy is written in Python to allow fast prototyping, but is also suitable for large-scale experiments through its built-in support for optimized numerical libraries and parallelization. Code profiling, domain visualizations, and data analysis are integrated in a self-contained package available under the Modified BSD License at
http://github.com/rlpy/rlpy. All of these properties allow users to compare various reinforcement learning algorithms with little effort
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