Synthesis and application of new rhodamine 6G-derivative fluorescent probe molecules

In the text, a new fluorescent probe based on rhodamine spirolactam ring was designed and synthesized. Rhodamine-like derivatives have not only good response speed and luminous performance, but also have a special switch type structure, which can specifically recognize responsive metal ions. In the paper, Rh-TEF, a 6G derivative of rhodamine, was synthesized by condensation reaction, the synthesized fluorescent probe was successfully used for solutions sample detection

Effects of Botulinum Toxin A on the Blood Flow in Expanded Rat Skin

Background Poor blood supply can easily lead to expander extrusion and necrosis at the distal expanded flap. Botulinum toxin A (BTX-A) has been previously found to improve pedicled flap blood flow perfusion, but its effects on the blood supply of expanded skin remain unclear. Therefore, this study aimed to evaluate the effects of BTX-A on blood flow perfusion during and after expansion. Methods Eighteen Sprague-Dawley rats were randomly divided into a BTX-A group and a control group. BTX-A or normal saline was injected intradermally into the marked skin on the back immediately. Then expanders were implanted in the rats. One week later, inflation of the expander with normal saline was started and performed twice a week to reach an intracapsular pressure of 8 kPa. The skin blood flow was measured before each injection. After 4 weeks of expansion, the sample was harvested for histological staining to measure the diameter and density of blood vessels; meanwhile, a 2 cm× 8 cm expanded random flap was elevated and sutured in situ. Blood flow perfusion and flap survival were observed. Results Compared with the control group, the BTX-A group had more blood flow, a larger blood vessel diameter, and higher blood vessel density in the expanded skin. Additionally, the flap of the BTX-A group had good blood flow perfusion and a high proportion of flap survival area within 7 days after expanded flap transfer. Data were analyzed using an independent t-test. Conclusion Pre-surgical BTX-A treatment may increase angiogenesis and vasodilatation, with subsequent blood perfusion elevation during and after expansion, and obtain a greater proportion of survival area of the transferred expanded flap

A denoising method based on cyclegan with attention mechanisms for improving the hidden distress features of pavement

Abstract Ground Penetrating Radar (GPR) is one of the most used devices for road structural damages detection. However, due to the different roadbed conditions and various disturbances in the nearby environment during detection, there are great difficulties in interpreting detection images, which also hinders automatic detection based on deep learning. In this work, we design a GPR image denoising method based on Cyclegan. We select the most suitable generator and add different attention mechanisms. After denoising the natural GPR road detection image, using the Yolo (You Only Look Once) to test the accuracy of the original image and the denoised image after adding different attention mechanisms. The detection accuracy is improved by 30%. The results of the detection network and the evaluation of the denoised images by GPR image interpreters indicate that the method has the following advantages: lower requirements for training data sets, a wide range of data sources, low cost, good denoising effect, and automatic detection of GPR images. It is of great help to the automatic detection of GPR images