Radial basis function approach in nuclear mass predictions

The radial basis function (RBF) approach is applied in predicting nuclear masses for 8 widely used nuclear mass models, ranging from macroscopic-microscopic to microscopic types. A significantly improved accuracy in computing nuclear masses is obtained, and the corresponding rms deviations with respect to the known masses is reduced by up to 78%. Moreover, strong correlations are found between a target nucleus and the reference nuclei within about three unit in distance, which play critical roles in improving nuclear mass predictions. Based on the latest Weizs\"{a}cker-Skyrme mass model, the RBF approach can achieve an accuracy comparable with the extrapolation method used in atomic mass evaluation. In addition, the necessity of new high-precision experimental data to improve the mass predictions with the RBF approach is emphasized as well.Comment: 18 pages, 8 figure

Fouling mechanisms in constant flux crossflow ultrafiltration

Four fouling models due to Hermia (complete pore blocking, intermediate pore blocking, cake filtration and standard pore blocking), have long been used to describe membrane filtration and fouling in constant transmembrane pressure (ΔP) operation of membranes. A few studies apply these models to constant flux dead-end filtration systems. However, these models have not been reported for constant flux crossflow filtration, despite the frequent use of this mode of membrane operation in practical applications. We report derivation of these models for constant flux crossflow filtration. Of the four models, complete pore blocking and standard pore blocking were deemed inapplicable due to contradicting assumptions and relevance, respectively. Constant flux crossflow fouling experiments of dilute latex bead suspensions and soybean oil emulsions were conducted on commercial poly (ether sulfone) flat sheet ultrafiltration membranes to explore the models’ abilities to describe such data. A model combining intermediate pore blocking and cake filtration appeared to give the best agreement with the experimental data. Below the threshold flux, both the intermediate pore blocking model and the combined model fit the data well. As permeate flux approached and passed the threshold flux, the combined model was required for accurate fits. Based on this observation, a physical interpretation of the threshold flux is proposed: the threshold flux is the flux below which cake buildup is negligible and above which cake filtration becomes the dominant fouling mechanism

MObile Technology for Improved Family Planning: update to randomised controlled trial protocol.

BACKGROUND: This update outlines changes to the MObile Technology for Improved Family Planning study statistical analysis plan and plans for long-term follow-up. These changes result from obtaining additional funding and the decision to restrict the primary analysis to participants with available follow-up data. The changes were agreed prior to finalising the statistical analysis plan and sealing the dataset. METHODS/DESIGN: The primary analysis will now be restricted to subjects with data on the primary outcome at 4-month follow-up. The extreme-case scenario, where all those lost to follow-up are counted as non-adherent, will be used in a sensitivity analysis. In addition to the secondary outcomes outlined in the protocol, we will assess the effect of the intervention on long-acting contraception (implant, intra-uterine device and permanent methods).To assess the long-term effect of the intervention, we plan to conduct additional 12-month follow-up by telephone self-report for all the primary and secondary outcomes used at 4 months. All participants provided informed consent for this additional follow-up when recruited to the trial. Outcome measures and analysis at 12 months will be similar to those at the 4-month follow-up. The primary outcomes of the trial will be the use of an effective modern contraceptive method at 4 months and at 12 months post-abortion. Secondary outcomes will include long-acting contraception use, self-reported pregnancy, repeat abortion and contraception use over the 12-month post-abortion period. DISCUSSION: Restricting the primary analysis to those with follow-up data is the standard approach for trial analysis and will facilitate comparison with other trials of interventions designed to increase contraception uptake or use. Undertaking 12-month trial follow-up will allow us to evaluate the long-term effect of the intervention. TRIAL REGISTRATION: ClinicalTrials.gov NCT01823861

A generalized bayesian inference method for constraining the interiors of super Earths and sub-Neptunes

We aim to present a generalized Bayesian inference method for constraining interiors of super Earths and sub-Neptunes. Our methodology succeeds in quantifying the degeneracy and correlation of structural parameters for high dimensional parameter spaces. Specifically, we identify what constraints can be placed on composition and thickness of core, mantle, ice, ocean, and atmospheric layers given observations of mass, radius, and bulk refractory abundance constraints (Fe, Mg, Si) from observations of the host star's photospheric composition. We employed a full probabilistic Bayesian inference analysis that formally accounts for observational and model uncertainties. Using a Markov chain Monte Carlo technique, we computed joint and marginal posterior probability distributions for all structural parameters of interest. We included state-of-the-art structural models based on self-consistent thermodynamics of core, mantle, high-pressure ice, and liquid water. Furthermore, we tested and compared two different atmospheric models that are tailored for modeling thick and thin atmospheres, respectively. First, we validate our method against Neptune. Second, we apply it to synthetic exoplanets of fixed mass and determine the effect on interior structure and composition when (1) radius, (2) atmospheric model, (3) data uncertainties, (4) semi-major axes, (5) atmospheric composition (i.e., a priori assumption of enriched envelopes versus pure H/He envelopes), and (6) prior distributions are varied. Our main conclusions are: [...]Comment: Astronomy & Astrophysics, 597, A37, 17 pages, 11 figure

Generalized thermo vacuum state derived by the partial trace method

By virtue of the technique of integration within an ordered product (IWOP) of operators we present a new approach for deriving generalized thermo vacuum state which is simpler in form that the result by using the Umezawa-Takahashi approach, in this way the thermo field dynamics can be developed. Applications of the new state are discussed.Comment: 5 pages, no figure, revtex

MicroRNA-23a promotes myelination in the central nervous system.

Demyelinating disorders including leukodystrophies are devastating conditions that are still in need of better understanding, and both oligodendrocyte differentiation and myelin synthesis pathways are potential avenues for developing treatment. Overexpression of lamin B1 leads to leukodystrophy characterized by demyelination of the central nervous system, and microRNA-23 (miR-23) was found to suppress lamin B1 and enhance oligodendrocyte differentiation in vitro. Here, we demonstrated that miR-23a-overexpressing mice have increased myelin thickness, providing in vivo evidence that miR-23a enhances both oligodendrocyte differentiation and myelin synthesis. Using this mouse model, we explored possible miR-23a targets and revealed that the phosphatase and tensin homologue/phosphatidylinositol trisphosphate kinase/Akt/mammalian target of rapamycin pathway is modulated by miR-23a. Additionally, a long noncoding RNA, 2700046G09Rik, was identified as a miR-23a target and modulates phosphatase and tensin homologue itself in a miR-23a-dependent manner. The data presented here imply a unique role for miR-23a in the coordination of proteins and noncoding RNAs in generating and maintaining healthy myelin

Study of Λb→Λ(ϕ,η(′))\Lambda_b\to \Lambda (\phi,\eta^{(\prime)}) and Λb→ΛK+K−\Lambda_b\to \Lambda K^+K^- decays

We study the charmless two-body $\Lambda_b\to \Lambda (\phi,\eta^{(\prime)})$ and three-body $\Lambda_b\to \Lambda K^+K^-$ decays. We obtain ${\cal B}(\Lambda_b\to \Lambda\phi)=(3.53\pm 0.24)\times 10^{-6}$ to agree with the recent LHCb measurement. However, we find that ${\cal B}(\Lambda_b\to \Lambda(\phi\to)K^+ K^-)=(1.71\pm 0.12)\times 10^{-6}$ is unable to explain the LHCb observation of ${\cal B}(\Lambda_b\to\Lambda K^+ K^-)=(15.9\pm 1.2\pm 1.2\pm 2.0)\times 10^{-6}$, which implies the possibility for other contributions, such as that from the resonant $\Lambda_b\to K^- N^*,\,N^*\to\Lambda K^+$ decay with $N^*$ as a higher-wave baryon state. For $\Lambda_b\to \Lambda \eta^{(\prime)}$, we show that ${\cal B}(\Lambda_b\to \Lambda\eta,\,\Lambda\eta^\prime)= (1.47\pm 0.35,1.83\pm 0.58)\times 10^{-6}$, which are consistent with the current data of $(9.3^{+7.3}_{-5.3},<3.1)\times 10^{-6}$, respectively. Our results also support the relation of ${\cal B}(\Lambda_b\to \Lambda\eta) \simeq {\cal B}(\Lambda_b\to\Lambda\eta^\prime)$, given by the previous study.Comment: 8 pages, 1 figure, revised version accepted by EPJ

Non-leptonic two-body weak decays of Λc(2286)\Lambda_c(2286)

We study the non-leptonic two-body weak decays of $\Lambda_c^+(2286)\to {\bf B}_n M$ with ${\bf B}_n$ ($M$) representing as the baryon (meson) states. Based on the $SU(3)$ flavor symmetry, we can describe most of the data reexamined by the BESIII Collaboration with higher precisions. However, our result of ${\cal B}(\Lambda_c^+ \to p\pi^0)=(5.6\pm 1.5)\times 10^{-4}$ is larger than the current experimental limit of $3\times10^{-4}$ (90\% C.L.) by BESIII. In addition, we find that ${\cal B}(\Lambda_c^+ \to \Sigma^+ K^0)=(8.0\pm 1.6)\times 10^{-4}$, ${\cal B}(\Lambda_c^+ \to \Sigma^+ \eta^\prime)=(1.0^{+1.6}_{-0.8})\times 10^{-2}$, and ${\cal B}(\Lambda_c^+ \to p \eta^\prime)=(12.2^{+14.3}_{-\,\,\,8.7})\times 10^{-4}$, which are accessible to the BESIII experiments.Comment: 12 pages, 1 figure, revised version accepted by PL