Bioactive Phenolics from Carthamus lanatus L.

Two flavonoid aglycons, eight flavonoid glycosides, chlorogenic acid and syringin were isolated from aerial parts of Carthamus lanatus. Isorhamnetin 3-O-β-D-glucoside and chlorogenic acid were found for the first time in the genus Carthamus and respectively, quercimeritrin, astragalin, kaempferol 3-O-β-D-sophoroside and syringin in the species. The ethyl acetate fraction of the methanol extract exhibited a higher antioxidant activity than the butanol fraction measured by the α,α-diphenyl-β -picrazylhydrazyl (DPPH) free radical scavenging assay. Cytotoxicity and antioxidant activities of the main constituent, luteolin 7-O-β-D-glucoside, were evaluated

NMR Investigation and Conformational Analysis of a Synthetic Hexasaccharide

The structure of the hexasaccharide 1 has been examined by a spectroscopic investigation using one- and two-dimensional NMR spectroscopy. All 1H and 13C signals of the saccharide part were assigned. NOESY and ROESY experiments allowed to discuss the flexibility of the molecule

Novel double functional protection of cephalostatin analogues using a gas-free chlorination method

Herewith, we report on a method that allows to simultaneously protect both the ∆14,15 bond and the carbonyl group of the symmetrical bis-steroidal diketone 2. We found that environmentally friendly and gas-free chlorination is ideally suited to achieve this goal. This method was discovered during our efforts to methoxylate 2 in a solution of dichloromethane and basic methanol in the presence of diacetoxy iodobenzene. Unexpectedly, the ∆14,15 bonds were chlorinated once as well as twice in a statistical manner. Interestingly, the singly dichlorinated desymmetrized product is an ideal precursor for conduction a series of position selective transformations. Importantly, the carbonyl group present in the nonchlorinated hemisphere can be selectively reduced, olefinated or oximated, while the other carbonyl group stays unaltered. A structurally related “monomeric” steroid derivative undergoes ∆14,15 chlorination and 11-position methoxylation under same conditions. These findings represent a powerful entry for preparing new nonsymmetrical cephalostatin derivatives. © 201

Oxygenated bisabolane fucosides from Carthamus lanatus L.

The aerial parts of Carthamus lanatus (Asteraceae) afforded four new oxygenated bisabolane fucosides, 10-hydroperoxy-bisabola-2,11-diene 7-O-β-D-fucopyranoside, 11-hydroperoxy-bisabola-2,9-diene 7-O-β-D-fucopyranoside, 10-hydroxy-bisabola-2,11-diene 7-O-β-D- fucopyranoside and 11-hydroxy-bisabola-2,9-diene 7-O-β-D-fucopyranoside together with the known compounds α-bisabolol β-D-fucopyranoside, asperuloside, sitosterol 3-O-β-D-glucoside and stigmasterol 3-O-β-D-glucoside. Asperuloside appears to be the second representative of the iridoid monoterpene group found in the plant family Asteraceae, which until recently was considered to lack iridoids. The main constituent α-bisabolol fucoside exhibited noticeable antibacterial and cytotoxic activities

Clastogenic Effect of Carthamus lanatus L. (Asteraceae)

The clastogenic effect of total dichloromethane, methanol and water extracts, four bioactive fractions and three individual constituents from Carthamus lanatus aerial parts were evaluated in mice by bone marrow chromosome aberration assay with mitomycin C as positive control. Significant differences in the percentage of aberrant mitosis of the extracts were observed. The dichloromethane extract exhibited a considerable clastogenic effect and the water extract a negligible one. Different types of chromosome aberrations and time-dependant effects for the active fractions and individual compounds were found

A Novel Triterpene Saponin from Gypsophila capillaris

A novel C-28 tetraglycoside of quillaic acid (1) has been isolated from Gypsophila capillaris. The structure was elucidated by 1 D NMR (NOE difference, DEPT, selective13C{1H} INEPT), 2D NMR (1H,1H and1H,13C COSY,1H,1H,1H RELAY, ROESY and TOCSY) and other spectroscopic and chromatographic evidences. Conformational dynamics within the tetrasaccharide part were estimated from NOE responses and ROESY peaks. © 1995 Verlag der Zeitschrift für Naturforschung. All rights reserved

In vitro Anti-inflammatory Effect of Carthamus lanatus L.

The anti-inflammatory activity of four total extracts, their fractions and two main constituents (α-bisabolol β-D-fucopyranoside and luteolin 7-O-glucoside) of Carthamus lanatus L. aerial parts, were assessed in vitro by determining the inhibitory effects on induced human neutrophils. The dichloromethane extract and its water-alcoholic part exhibited the most significant inhibitory effects

Isoflavonoids from taverniera abyssinica

Bu11.Chem.Soc.Ethiop. ,1(1), 36-41 (1987)