Nicht-Cholera-Vibrionen – derzeit noch seltene, aber wachsende Infektionsgefahr in Nord- und Ostsee

Hintergrund: Nicht-Cholera-Vibrionen nehmen im Rahmen des Klimawandels eine zunehmende Bedeutung als humane Pathogene ein, da die Prävalenz dieser Erreger im Meereswasser entscheidend von der Wassertemperatur abhängt. In den letzten Jahren konnten während der Sommermonate wiederholt größere Infektionsausbrüche in gemäßigten Klimazonen beobachtet werden. Ziel der Arbeit: Information einer breiten ärztlichen Leserschaft über potenziell lebensbedrohliche Krankheitsbilder, die durch Infektionen mit Nicht-Cholera-Vibrionen ausgelöst werden. Material und Methoden: Übersicht über aktuelle Literatur zu Infektionen mit Nicht-Cholera-Vibrionen im Allgemeinen und zur epidemiologischen Situation in Deutschland im Speziellen. Ergebnisse: Nicht-Cholera-Vibrionen verursachen vorwiegend Wund- und Ohrinfektionen nach Kontakt mit kontaminiertem Meereswasser sowie Gastroenteritiden nach dem Konsum nicht ausreichend gegarter Meerestiere. Da bis März 2020 keine Meldepflicht für diese Erreger in Deutschland bestand, muss von einer hohen Dunkelziffer ausgegangen werden. Immunsupprimierte sowie chronisch erkrankte Menschen haben ein deutlich erhöhtes Risiko für schwere Krankheitsverläufe. Schon bei klinischem Verdacht sollte eine kalkulierte antiinfektive Therapie erfolgen und bei Wundinfektionen eine chirurgische Sanierung erwogen werden. Diskussion: Aufgrund des fortschreitenden Klimawandels muss in den kommenden Jahren mit dem vermehrten Auftreten von Infektionen mit Nicht-Cholera-Vibrionen gerechnet werden. Ärzte sollten über diese potenziell lebensbedrohlichen Erkrankungen informiert sein, um Patienten einer entsprechenden Diagnostik und Behandlung zuzuführen.Background: The abundance of non-cholera Vibrio spp. in the aquatic environment shows a positive correlation with water temperatures. Therefore, climate change has an important impact on the epidemiology of human infections with these pathogens. In recent years large outbreaks have been repeatedly observed during the summer months in temperate climate zones. Objective: To inform medical professionals about the potentially life-threatening diseases caused by non-cholera Vibrio spp. Material and methods: Review of the current literature on infections with non-cholera Vibrio spp. in general and on the epidemiological situation in Germany in particular. Results: Non-cholera Vibrio spp. predominantly cause wound and ear infections after contact with contaminated seawater and gastroenteritis after consumption of undercooked seafood. As there have not been mandatory notification systems for these pathogens in Germany up to March 2020, a high number of unreported cases must be assumed. Immunosuppressed and chronically ill patients have a much higher risk for severe courses of diseases. If an infection with non-cholera Vibrio spp. is suspected anti-infective treatment should be promptly initiated and surgical cleansing is often necessary for wound and soft tissue infections. Conclusion: Due to the ongoing global warming an increased incidence of human infections with non-cholera Vibrio spp. must be expected in the future. Medical professionals should be aware of these bacterial pathogens and the potentially life-threatening infections in order to enable timely diagnostics and treatment.Peer Reviewe

Processing of MEMPHIS Ka-Band Multibaseline Interferometric SAR Data: From Raw Data to Digital Surface Models

MEMPHIS is an experimental millimeter-wave synthetic aperture radar (SAR) system that acquires cross-track multibaseline interferometric data at high resolution in a single pass, using four receive horns. In this paper, we present the SAR system and navigation data, and propose a processing chain from the raw data input to a digital surface model (DSM) output. This processing chain includes full bandwidth reconstruction of the stepped-frequency SAR data, azimuth focusing with an Extended Omega-K algorithm, generation of interferograms for each available baseline, phase unwrapping using the multibaseline data, and phase- to-height conversion. The hardware and processing chain were validated through the analysis of experimental Ka-band data. The SAR image resolution was measured with point targets and found to be    and     coarser than the theoretical value in range and azimuth, respectively. The geolocation accuracy was typically better than 0.1 m in range and 0.2 m in azimuth. Observed depression angle-dependent interferometric phase errors were successfully removed using a correction function derived from the InSAR data. Investigation of the interferometric phase noise showed the utility of a multi- baseline antenna setup; the number of looks and filter size used for the DSM generation were also derived from this analysis. The results showed that in grassland areas, the height difference between the ~2 m-resolution InSAR DSMs and the reference ALS models was 0 ±0.25 m

Steps to and correlates of health-enhancing physical activity in adulthood: An intercultural study between German and Chinese individuals

AbstractHealth-enhancing physical activity (HEPA) is a primary resource for improving physiological and psychosocial health. Stage models in the HEPA promotion area should fulfill three functions: description, intervention, and diagnosis. However, these functions have received insufficient attention, and research using an intercultural study paradigm has been rather scarce on this topic. The purpose of this study was to examine the three functions of a stage model by addressing the steps and correlates of HEPA behavior change process among adult samples from Germany and China. The 2071 adults (42% German and 58% Chinese), who were aged 27–55 years, completed self-administered questionnaires that assessed the quantity, intensity, and type of physical activity (PA) and assessed the stage of change. The following were also measured: five health correlates (i.e., fitness, physical complaints, body mass index, health satisfaction, and subjective well-being) and 10 psychosocial correlates (i.e., outcome expectations, affective attitude, barriers, self-efficacy, body concept, plans, intrinsic motivation, assessment of activity situation, activity emotions, and social support). The PA stages were significantly and positively correlated with the weekly energy consumption. In the health correlates and stages of change, all five health correlates significantly differed between the stages. In the psychosocial correlates and the stages of change, nine of 10 psychosocial correlates (with the exception of assessment of activity situation) significantly discriminated between the stages of change. In particular, nationality, gender, and education level are moderating factors for the characteristics of most health correlates across all stages of change. In addition, nationality, gender, and age moderated the relationship between the stage of change and some psychosocial correlates. The findings generally support the utility of a stage model for understanding German and Chinese adult HEPA behavior

Echinococcus multilocularis metacestode extract triggers human basophils to release interleukin-4

Infections with parasitic helminths are associated with a T helper 2 (Th2) immune response and IgE production. The underlying mechanism, however, is only partially understood. Recently we have isolated a protein from extracts of Schistosoma mansoni eggs that triggers human basophils from non-sensitized donors to release interleukin-4 (IL-4), the key cytokine of a Th2 response. We called this protein IPSE (for IL-4-inducing principle from Schistosoma mansoni eggs). Supposing that IPSE-like IL-4-inducing activities might be a general principle shared among different helminth species, we investigated extracts from the cestode E. multilocularis for its effect on human basophils. Our results showed that extracts from metacestodes of E. multilocularis cause basophil degranulation, as well as the secretion of histamine, IL-4 and IL-13, in a dose-dependent manner. IgE stripping and resensitization of basophils indicated that the mechanism of IL-4 induction requires the presence of IgE on the cells. Since analogous properties have been demonstrated earlier for IPSE, we think that S. mansoni and E. multilocularis may induce a Th2 response in their hosts via a related mechanism, namely, by the induction of IL-4 release from basophils

Later-Line Treatment with Lorlatinib in ALK- and ROS1-Rearrangement-Positive NSCLC: A Retrospective, Multicenter Analysis

In clinical practice, patients with anaplastic lymphoma kinase (ALK)-rearrangement–positive non–small-cell lung cancer commonly receive sequential treatment with ALK tyrosine kinase inhibitors. The third-generation agent lorlatinib has been shown to inhibit a wide range of ALK resistance mutations and thus offers potential benefit in later lines, although real-world data are lacking. This multicenter study retrospectively investigated later-line, real-world use of lorlatinib in patients with advanced ALK- or ROS1-positive lung cancer. Fifty-one patients registered in a compassionate use program in Austria, who received second- or later-line lorlatinib between January 2016 and May 2020, were included in this retrospective real-world data analysis. Median follow-up was 25.3 months. Median time of lorlatinib treatment was 4.4 months for ALK-positive and 12.2 months for ROS-positive patients. ALK-positive patients showed a response rate of 43.2%, while 85.7% percent of the ROS1-positive patients were considered responders. Median overall survival from lorlatinib initiation was 10.2 and 20.0 months for the ALK- and ROS1-positive groups, respectively. In the ALK-positive group, lorlatinib proved efficacy after both brigatinib and alectinib. Lorlatinib treatment was well tolerated. Later-line lorlatinib treatment can induce sustained responses in patients with advanced ALK- and ROS1-positive lung cancer