Aerosolized Amiloride for the Treatment of Lung Disease in Cystic Fibrosis

To the Editor: The April 26 issue of the Journal presented encouraging results by Knowles et al. regarding the beneficial effects of aerosolized amiloride in the treatment of cystic fibrosis.1 The introduction and discussion sections of this article described the function of amiloride as an inhibitor of sodium transport in the airway epithelium, and the authors suggested that the beneficial effects observed were exerted “at least in part by increasing the clearance of secretions.” Although the results of this investigation were promising in terms of the improvement in the decline of forced vital capacity in patients with cystic fibrosis, this

The Target Silicon Detector for the FOCUS Spectrometer

We describe a silicon microstrip detector interleaved with segments of a beryllium oxide target which was used in the FOCUS photoproduction experiment at Fermilab. The detector was designed to improve the vertex resolution and to enhance the reconstruction efficiency of short-lived charm particles.Comment: 18 pages, 14 figure

Seasonal acclimatization to temperature in cardueline finches

1. Seasonal variation in body constituents and utilization of lipid, protein, and carbohydrate during cold stress in American goldfinches were studied to determine relations of these functions to the pronounced seasonal shift in thermogenic capacity documented in a previous study (Dawson and Carey, 1976).Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47119/1/360_2004_Article_BF00686746.pd

Acculturation and cognitive performance of migrant children in the Netherlands

Acculturative strategies and cognitive acculturation were studied among 118 Dutch migrant children (age: 7-12 years). Both an exploratory factor analysis and a Linear Logistic Test Model analysis provided evidence for the bipolar unidimensionality of Berry's four acculturation strategies; integration constituted one pole and assimilation, separation, and marginalization the other. Integration was by far the most popular strategy. Cognitive performance was measured by the Snijders-Oomen Nonverbal Intelligence Test, school report measures, and a computer-assisted choice reaction-time measure. A good fit was found for a structural model that postulated cognitive acculturation as the latent variable linking background measures (i.e. acculturation strategy, second language usage, age, and gender) to the cognitive measures. Relationships between background variables and cognitive performance were stronger in the first than in the second generation. Both older children and children who favour an integration strategy showed a higher degree of cognitive acculturation

Cross-cultural differences in cognitive performance and Spearman's hypothesis

Common tests of Spearman's hypothesis, according to which performance differences between cultural groups on cognitive tests increase with their g loadings, confound cognitive complexity and verbal-cultural aspects. The present study attempts to disentangle these components. Two intelligence batteries and a computer-assisted elementary cognitive test battery were administered to 474 second-generation migrant and 747 majority-group pupils in the Netherlands, with ages ranging from 6 to 12 years. Theoretical complexity measures were derived from Carroll [Human cognitive abilities. A survey of factor-analytic studies. Cambridge: Cambridge Univ. Press] and Fischer [Psychol. Rev. 87 (1980) 477]. Cultural loadings of all subtests were rated by 25 third-year psychology students. Verbal loading was operationalized as the number of words in a subtest. A factor analysis of the subtest loadings on the first principal component, the theoretical complexity measures, and the ratings of cultural loading revealed two virtually unrelated factors, representing cognitive (g) and cultural complexity (c). The findings suggest that performance differences between majority-group members and migrant pupils are better predicted by c than by g.

Operations management teaching on European MBA programmes

A comprehensive review of the literature established that several investigations have been made of operations management teaching in the USA, whereas almost nothing has been published on European teaching. Therefore, an exploratory investigation was made of operations management teaching on the MBA courses of ten leading European business schools. The results show that course content is similar across schools, but there are large variations on three dimensions: the time allocated by schools to the subject; the balance between operations strategy and tools and techniques in teaching; and the level of emphasis given to service operations. The results also indicate the emerging importance of integrating operations management with other subjects in the MBA curriculum and the key challenge facing faculty - the need to raise the perceived importance of operations management. The comparison of courses will be of interest to all operations management faculty who teach core courses and particularly those who are looking for ideas on how to re-design courses

A Pilot Study of Aerosolized Amiloride for the Treatment of Lung Disease in Cystic Fibrosis

Excessive active absorption of sodium is a unique abnormality of the airway epithelium in patients with cystic fibrosis. This defect is associated with thickened mucus and poor clearance of airway secretions and may contribute to the pulmonary disease in these patients. To study whether the inhibition of excessive absorption of sodium might affect the course of lung disease in cystic fibrosis, we performed a double-blind, crossover trial comparing aerosolized amiloride (5 mmol per liter; 3.5 ml four times daily), a sodium-channel blocker, with vehicle alone. Fourteen of the 18 adult patients initially enrolled in the study completed the one-year trial (25 weeks for each treatment). The mean (±SEM) loss of forced vital capacity (FVC) was reduced from 3.39±1.13 ml per day during treatment with vehicle alone to 1.44±0.67 ml per day during treatment with amiloride (P<0.04). A measured index of sputum viscosity and elasticity was abnormal during treatment with vehicle alone and improved during treatment with amiloride. Calculated indexes of mucociliary and cough clearance also improved during amiloride treatment. No systemic, respiratory, or subjective toxic effects of amiloride were noted. We conclude from this preliminary study that aerosolized amiloride can be safely administered to adults with cystic fibrosis. The slowing of the loss of FVC and the improvement in sputum viscosity and elasticity suggest a beneficial clinical effect. Aerosolized amiloride deserves further evaluation in the treatment of lung disease in patients with cystic fibrosis