Early effects of unfractionated heparin on clinical and radiological signs and D-dimer levels in patients with COVID-19 associated pulmonary embolism: an observational cohort study

Perioperative Medicine: Efficacy, Safety and Outcome (Anesthesiology/Intensive Care

Pro/con debate Conservative oxygenation in the intensive care unit: Pro

Perioperative Medicine: Efficacy, Safety and Outcom

The effects of oxygen in critical illness

The side-effects of hyperoxia can be roughly subdivided in cell damage, inflammation, pulmonary complications, neurological symptoms and vascular effects. These features are responsible for the large majority of unfavourable effects and increased risk for morbidity and mortality following (prolonged) exposure to hyperoxia. From this thesis, we conclude that careful oxygen titration and monitoring is the best therapeutic strategy aimed at the prevention of potentially dangerous hyperoxia while preserving adequate tissue oxygenation. In this context, conservative oxygenation in the intensive care unit is a promising strategy to achieve better clinical outcomes for critically ill patients. Administering oxygen remains essential to prolong the window of opportunity and provide as much oxygen as necessary in anticipation of or during arterial hypoxia, and to rapidly establish pulmonary vasodilation or systemic vasoconstriction, when other measures are inadequate or fail. At the same time, clinicians should be well aware of the side-effects that are induced by supplying high levels of oxygen, as hyperoxia is also frequently encountered in critically ill patients.In expectation of compelling evidence from future clinical trials, targeting relative normoxia (80-150 mmHg) by avoiding exposure to both subphysiological as well as supraphysiological oxygenation should be considered the most rational choice in most patients.</p

When the Tank Is Running Low: Oxygen Targets to Improve Patient Care, Reduce Waste, and Increase Availability

Perioperative Medicine: Efficacy, Safety and Outcom

CON: routine hyperoxygenation in adult surgical patients whose tracheas are intubated

Perioperative Medicine: Efficacy, Safety and Outcom

Cerebral blood flow velocity during chest compressions in cardiac arrest

Perioperative Medicine: Efficacy, Safety and Outcom

Association Between Hyperoxia and Mortality After Cardiac Arrest Reply

AnesthesiologyPerioperative Medicine: Efficacy, Safety and Outcom

Association Between Arterial Hyperoxia and Outcome in Subsets of Critical Illness: A Systematic Review, Meta-Analysis, and Meta-Regression of Cohort Studies

Perioperative Medicine: Efficacy, Safety and Outcom