Pathogenic Yersinia and Listeria monocytogenes in organic pork production

The goal of this study is to determine the prevalence of pathogenic Yersinia and Listeria monocytogenes in organic pork production and assess risks in different steps of the pork production chain

ANALYSIS OF ELITE GOLFERS’ KINEMATIC SEQUENCE IN FULL-SWING AND PARTIAL SWING SHOTS

INTRODUCTION: Proximal-to-distal sequencing (PDS) has been observed in full-swing golf shots as in most throwing and striking skills, where the main goal is to maximize speed in the most distal segment of an open-link system (Zheng et al., 2007). Although PDS primarily is associated with mechanical advantage when the speed requirement is high, this temporal order has also been found and ascribed various merits in relatively slow multi-joint movements (Furuya & Kinoshita, 2007). However, no research to date has examined the sequencing pattern in partial golf shots to submaximal distances. The purpose here was to investigate whether PDS is a common characteristic also in partial swing shots of skilled golf players. METHODS: A total of 47 golfers were investigated, 11 male tournament professionals, 23 male amateurs (HCP 0 ± 2 strokes), and 13 female amateurs (HCP -2 ± 2 strokes) performed partial shots with a wedge to targets at three discrete distances (40, 55 and 70 m), and full-swing shots with a five iron as well as a driver in the same direction for maximal distance. Pelvis, upper torso, and hand movement were recorded in 3D with an electromagnetic tracking system (Polhemus) at 240 Hz. The magnitude of the resultant angular velocity vector of each segment was used to examine the sequencing pattern and the angular speed of segment motions. Movement onset, peak amplitude and time for peak amplitude were analyzed in separate repeated-measure ANOVAs with pre-planned Bonferroni corrected pairwise comparisons. Significance level was set at P < 0.05. RESULTS: This study showed a significant proximal-to-distal temporal relationship of movement onset and maximum angular speed at the pelvis, upper torso and hand segments in the golf swing. The same temporal structure was evident in all test conditions, as well as among different genders and levels of expertise. However, the increment in angular speed from the upper torso to hand were significantly larger for male professionals than for female amateurs at all shot conditions and significantly larger for male amateurs than for female amateurs at full-swing shots. DISCUSSION AND CONCLUSION: While there exists a body of evidence in support for PDS providing mechanical advantages when the highest possible ball speed is to be achieved, merits of PDS in partial golf shots are less evident. However, it has been proposed that a given torque or force can be more accurately generated by a stronger muscle than a weaker muscle (Hamilton et al., 2004) and a potential role of the observed sequencing pattern in partial shots of skilled golf players could be to improve accuracy and minimize the speed-accuracy tradeoff. REFERENCES: Zheng N., Barrentine S.W., Fleizig G.S., Andrews J.R. (2008). Kinematic analysis of swing in pro and amateur golfers, International Journal of Sports Medicine, 6, 487-493. Furuya S., Kinoshita H. (2007). Roles of proximal-to-distal sequential organization of the upper limb segments in striking the keys by expert pianists, Neuroscience Letters, 421, 264-269. Hamilton A., Jones K.E., Wolpert D.M. (2004). The scaling of motor noise with muscle strength and motor unit number in humans, Experimental Brain Research, 157, 417-430

Fragmentation of exotic oxygen isotopes

Abrasion-ablation models and the empirical EPAX parametrization of projectile fragmentation are described. Their cross section predictions are compared to recent data of the fragmentation of secondary beams of neutron-rich, unstable 19,20,21O isotopes at beam energies near 600 MeV/nucleon as well as data for stable 17,18O beams

Shared CSF Biomarker Profile in Idiopathic Normal Pressure Hydrocephalus and Subcortical Small Vessel Disease

Introduction: In this study, we examine similarities and differences between 52 patients with idiopathic normal pressure hydrocephalus (iNPH) and 17 patients with subcortical small vessel disease (SSVD), in comparison to 28 healthy controls (HCs) by a panel of cerebrospinal fluid (CSF) biomarkers. Methods: We analyzed soluble amyloid precursor protein alpha (sAPPα) and beta (sAPPβ), Aβ isoforms −38, −40, and −42, neurofilament light protein (NFL), glial fibrillary acidic protein (GFAP), myelin basic protein (MBP), matrix metalloproteinases (MMP −1, −2, −3, −9, and −10), and tissue inhibitors of metalloproteinase 1 (TIMP1). Radiological signs of white matter damage were scored using the age-related white matter changes (ARWMC) scale. Results: All amyloid fragments were reduced in iNPH and SSVD (p < 0.05), although more in iNPH than in SSVD in comparison to HC. iNPH and SSVD showed comparable elevations of NFL, MBP, and GFAP (p < 0.05). MMPs were similar in all three groups except for MMP-10, which was increased in iNPH and SSVD. Patients with iNPH had larger ventricles and fewer WMCs than patients with SSVD. Conclusion: The results indicate that patients with iNPH and SSVD share common features of subcortical neuronal degeneration, demyelination, and astroglial response. The reduction in all APP-derived proteins characterizing iNPH patients is also present, indicating that SSVD encompasses similar pathophysiological phenomena as iNPH

Plasma and cerebrospinal fluid concentrations of neurofilament light protein correlate in patients with idiopathic normal pressure hydrocephalus

BACKGROUND: Neurofilament light chain protein (NFL), a marker of neuronal axonal degeneration, is increased in cerebrospinal fluid (CSF) of patients with idiopathic normal pressure hydrocephalus (iNPH). Assays for analysis of NFL in plasma are now widely available but plasma NFL has not been reported in iNPH patients. Our aim was to examine plasma NFL in iNPH patients and to evaluate the correlation between plasma and CSF levels, and whether NFL levels are associated with clinical symptoms and outcome after shunt surgery. METHODS: Fifty iNPH patients with median age 73 who had their symptoms assessed with the iNPH scale and plasma and CSF NFL sampled pre- and median 9 months post-operatively. CSF plasma was compared with 50 healthy controls (HC) matched for age and gender. Concentrations of NFL were determined in plasma using an in-house Simoa method and in CSF using a commercially available ELISA method. RESULTS: Plasma NFL was elevated in patients with iNPH compared to HC (iNPH: 45 (30-64) pg/mL; HC: 33 (26-50) (median; Q1-Q3), p = 0.029). Plasma and CSF NFL concentrations correlated in iNPH patients both pre- and postoperatively (r = 0.67 and 0.72, p < 0.001). We found only weak correlations between plasma or CSF NFL and clinical symptoms and no associations with outcome. A postoperative NFL increase was seen in CSF but not in plasma. CONCLUSIONS: Plasma NFL is increased in iNPH patients and concentrations correlate with CSF NFL implying that plasma NFL can be used to assess evidence of axonal degeneration in iNPH. This finding opens a window for plasma samples to be used in future studies of other biomarkers in iNPH. NFL is probably not a very useful marker of symptomatology or for prediction of outcome in iNPH

UK Criteria for Uterus Transplantation: A Review

Absolute Uterine Factor Infertility (AUFI) is the final hurdle for assisted reproductive treatments. Uterus transplant trials are happening worldwide; in order to advance the debate around uterine transplantation (UTx) this article considers selection criteria for clinical trials from a UK perspective and makes recommendations for future selection criteria for UTx treatment. Recommendations advanced include the use of donor eggs, access for single women and women in same-sex relationships, prohibiting participation of women who are already mothers, and a preference for deceased donors and bioengineered uteri. With UTx treatment on the horizon it is important to proactively consider future selection criteria

Evidence-Based Interventions and Strategies for the Grand Challenges Approach: The Need for Judgement

What is the value of evidence-based interventions in addressing “Grand Challenges”? Building upon the EPOS Grand Challenges work (Sakhrani et al., 2017), this paper explores whether evidence-based approaches developed for management and policy are relevant to addressing Grand Challenges. It discusses the criticisms of the Evidence-based Management approach and argues that evidence is a necessary, but not sufficient input in the decisionmaking process of addressing Grand Challenges