What Process is Due? Courts and Science-Policy Disputes

A Review of What Process is Due? Courts and Science-Policy Disputes by David M. O\u27Brie

Differential Functional Connectivity of Rostral Anterior Cingulate Cortex During Emotional Interference

The rostral-ventral subdivision of the anterior cingulate cortex (rACC) plays a key role in the regulation of emotional processing. Although rACC has strong anatomical connections with anterior insular cortex (AIC), amygdala, prefrontal cortex and striatal brain regions, it is unclear whether the functional connectivity of rACC with these regions changes when regulating emotional processing. Furthermore, it is not known whether this connectivity changes with deficits in emotion regulation seen in different kinds of anxiety and depression. To address these questions regarding rACC functional connectivity, non-patients high in self-reported anxious apprehension (AP), anxious arousal (AR), anhedonic depression (AD) or none (CON) indicated the ink color of pleasant, neutral and unpleasant words during functional magnetic resonance imaging. While ignoring task-irrelevant unpleasant words, AD and CON showed an increase in the functional connectivity of rACC with AIC, putamen, caudate and ventral pallidum. There was a decrease in this connectivity in AP and AR, with AP showing greater reduction than AR. These findings provide support for the role of rACC in integrating interoceptive, emotional and cognitive functions via interactions with insula and striatal regions during effective emotion regulation in healthy individuals and a failure of this integration that may be specific to anxiety, particularly AP

Preclinical studies in Krabbe disease: A model for the investigation of novel combination therapies for lysosomal storage diseases

Krabbe disease (KD) is a lysosomal storage disease (LSD) caused by mutations in the galc gene. There are over 50 monogenetic LSDs, which largely impede the normal development of children and often lead to premature death. At present, there are no cures for LSDs and the available treatments are generally insufficient, short acting, and not without co-morbidities or long-term side effects. The last 30 years have seen significant advances in our understanding of LSD pathology as well as treatment options. Two gene therapy-based clinical trials, NCT04693598 and NCT04771416, for KD were recently started based on those advances. This review will discuss how our knowledge of KD got to where it is today, focusing on preclinical investigations, and how what was discovered may prove beneficial for the treatment of other LSDs

The Phase Diagram of High Temperature QCD with Three Flavors of Improved Staggered Quarks

We report on progress in our study of high temperature QCD with three flavors of improved staggered quarks. Simulations are being carried out with three degenerate quarks with masses less than or equal to the strange quark mass, $m_s$, and with degenerate up and down quarks with masses in the range $0.1 m_s \leq m_{u,d}\leq 0.6 m_s$, and the strange quark mass fixed near its physical value. For the quark masses studied to date we find rapid crossovers, which sharpen as the quark mass is reduced, rather than bona fide phase transitions.Comment: Lattice 2003 (Nonzero temperature and density

Differential Functional Connectivity of Rostral Anterior Cingulate Cortex During Emotional Interference

The rostral-ventral subdivision of the anterior cingulate cortex (rACC) plays a key role in the regulation of emotional processing. Although rACC has strong anatomical connections with anterior insular cortex (AIC), amygdala, prefrontal cortex and striatal brain regions, it is unclear whether the functional connectivity of rACC with these regions changes when regulating emotional processing. Furthermore, it is not known whether this connectivity changes with deficits in emotion regulation seen in different kinds of anxiety and depression. To address these questions regarding rACC functional connectivity, non-patients high in self-reported anxious apprehension (AP), anxious arousal (AR), anhedonic depression (AD) or none (CON) indicated the ink color of pleasant, neutral and unpleasant words during functional magnetic resonance imaging. While ignoring task-irrelevant unpleasant words, AD and CON showed an increase in the functional connectivity of rACC with AIC, putamen, caudate and ventral pallidum. There was a decrease in this connectivity in AP and AR, with AP showing greater reduction than AR. These findings provide support for the role of rACC in integrating interoceptive, emotional and cognitive functions via interactions with insula and striatal regions during effective emotion regulation in healthy individuals and a failure of this integration that may be specific to anxiety, particularly AP

Heavy-light meson decay constants with N_f=3

During the past year the MILC Collaboration has continued its study of heavy-light meson decay constants with three dynamical quarks. Calculations have been extended to a second lattice spacing of about 0.09 fm. At this lattice spacing, there are results in the quenched approximation and for three sets of dynamical quark mass: m_l=m_s; m_l=0.4 m_s and m_l=0.2 m_s, where m_l is the light mass for the u and d quarks and m_s is the strange quark mass. At the coarser lattice spacing, for which results were presented at Lattice 2001, statistics have been increased for two sets of quark masses and three additional sets of quark masses have been studied, giving a total of eight combinations used to interpolate between the quenched and chiral limits. When these calculations are completed, we can study the decay constants taking into account both chiral and continuum extrapolations.Comment: Lattice2002(heavyquark), 3 pages, 3 color figures, to appear in the proceedings of Lattice 200