Spectroscopy from 2 to 200 keV

The astrophysical processes responsible for line and continuum emission in the spectra range 2 keV to 200 keV are examined from the viewpoint of designing a spectrometer which would operate in this regime. Phenomena considered include fluorescent line radiation in X-ray binaries, magnetically shifted iron lines and cyclotron emission from neutron star surfaces, line emission from cosmically abundant elements in thermal plasmas, and nuclear deexcitation lines in fresh nucleosynthetically produced matter. An instrument consisting of a approximately 10 sq cm array of planar germanium detectors surrounded by a large sodium-iodide anticoincidence shield is described and projected background rates and sensitivities are considered. A sample observing program for a two-day shuttle-based mission is included as an example of the wide range of scientific questions which could be addressed by such an instrument

The BCS Critical Temperature in a Weak External Electric Field via a Linear Two-Body Operator

We study the critical temperature of a superconductive material in a weak external electric potential via a linear approximation of the BCS functional. We reproduce a similar result as in Frank et al. (Commun Math Phys 342(1):189–216, 2016, [5]) using the strategy introduced in Frank et al. (The BCS critical temperature in a weak homogeneous magnetic field, [2]), where we considered the case of an external constant magnetic field

The BCS critical temperature in a weak external electric field via a linear two-body operator

We study the critical temperature of a superconductive material in a weak external electric potential via a linear approximation of the BCS functional. We reproduce a similar result as in [Frank, Hainzl, Seiringer, Solovej, 2016] using the strategy introduced in [Frank, Hainzl, Langmann, 2018], where we considered the case of an external constant magnetic field.Comment: Dedicated to Herbert Spohn on the occasion of his seventieth birthday; 29 page

Accurate sampling using Langevin dynamics

We show how to derive a simple integrator for the Langevin equation and illustrate how it is possible to check the accuracy of the obtained distribution on the fly, using the concept of effective energy introduced in a recent paper [J. Chem. Phys. 126, 014101 (2007)]. Our integrator leads to correct sampling also in the difficult high-friction limit. We also show how these ideas can be applied in practical simulations, using a Lennard-Jones crystal as a paradigmatic case

The 3-53 keV Spectrum of the Quasar 1508+5714: X-rays from z = 4.3

We present a high-quality X-ray spectrum in the 3--53 keV rest-frame band of the radio-loud quasar 1508+5714, by far the brightest known X-ray source at z > 4. A simple power-law model with an absorption column density equal to the Galactic value in the direction of the source provides an excellent and fully adequate fit to the data; the measured power-law photon index Gamma = 1.42 (+0.13,-0.10). Upper limits to Fe K alpha line emission and Compton-reflection components are derived. We offer evidence for both X-ray and radio variability in this object and provide the first contemporaneous radio spectrum (alpha = -0.25). The data are all consistent with a picture in which the emission from this source is dominated by a relativistically beamed component in both the X-ray and radio bands.Comment: 8 pages, TeX, 2 postscript figures; to appear in ApJ Letter

Dasatinib Modulates Invasive and Migratory Properties of Canine Osteosarcoma and has Therapeutic Potential in Affected Dogs

AbstractBACKGROUND: This investigation sought to elucidate the relationship between hepatocyte growth factor (HGF)–induced metastatic behavior and the tyrosine kinase inhibitors (TKIs) crizotinib and dasatinib in canine osteosarcoma (OS). Preliminary evidence of an apparent clinical benefit from adjuvant therapy with dasatinib in four dogs is described. METHODS: The inhibitors were assessed for their ability to block phosphorylation of MET; reduce HGF-induced production of matrix metalloproteinase (MMP); and prevent invasion, migration, and cell viability in canine OS cell lines. Oral dasatinib (0.75 mg/kg) was tested as an adjuvant therapy in four dogs with OS. RESULTS: Constitutive phosphorylation of MET was detected in two cell lines, and this was unaffected by 20-nM incubation with either dasatinib or crizotinib. Incubation of cell lines with HGF (MET ligand) increased cell migration and invasion in both cell lines and increased MMP-9 activity in one. Dasatinib suppressed OS cell viability and HGF-induced invasion and migration, whereas crizotinib reduced migration and MMP-9 production but did not inhibit invasion or viability. CONCLUSIONS: Invasion, migration, and viability of canine OS cell lines are increased by exogenous HGF. HGF induces secretion of different forms of MMP in different cell lines. The HGF-driven increase in viability and metastatic behaviors we observed are more uniformly inhibited by dasatinib. These observations suggest a potential clinical benefit of adjuvant dasatinib treatment for dogs with OS