Supplementary Text

Contains all mathematical derivations, detailed methodological descriptions, etc., mentioned in the main text of the article

Supplementary Tables

Contains all supplementary tables (S1-S14)

Supplementary Figures

Contains all supplementary figures (S1-S7)

Code and simulation data

Zipped folder with code and simulation data

Microscopy data - Part 4

Zipped microscopy data split by Mac OS, 8 parts in total

README_computer_code

This file describes how to use the deposited code and simulation data to reproduce the manuscript figures

정부부문 부패실태에 관한 연구

Zipped microscopy data split by Mac OS, 8 parts in total

Microscopy data - Part 2

Zipped microscopy data split by Mac OS, 8 parts in total

Phenotypic delay in <i>E</i>. <i>coli</i>.

<p>(A) Phenotypic penetrance (mean ± SE; <i>n</i> = 6) over time for three antibiotic resistance mutations. Gray dashed lines: time at 50% phenotypic penetrance. (B) Frequency of homozygous mutants among all mutants (orange) for the three resistance mutations assessed by <i>lacZ</i> reporter constructs (<i>rpoB-lacZ</i>, <i>gyrA-lacZ</i>, <i>rpsL-lacZ</i>), overlaid with their respective phenotypic penetrance. (C) Genotypic mutant frequency for the resistance mutations. (D) Phenotypic penetrance of the lactose prototrophy (<i>rpsL-lacZ</i>) mutation. (E) Colonies founded by homozygous (blue) and heterozygous (sectored) lac⁺ mutants. The numerical data for panels A to D can be found in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.2004644#pbio.2004644.s005" target="_blank">S1 Data</a>. MIC, minimum inhibitory concentration.</p

Approximate mutant frequencies at mutation–selection balance.

<p>Ploidy is <i>c</i> = 2^<i>n</i> (<i>n</i> ≥ 1) in the polyploid cases, is the per-copy mutation rate, and <i>s</i> is the cost of the mutation in homozygotes (in heterozygotes, the cost is masked in the recessive case but expressed in the dominant case).</p