14 research outputs found
Supplementary Text
Contains all mathematical derivations, detailed methodological descriptions, etc., mentioned in the main text of the article
README_computer_code
This file describes how to use the deposited code and simulation data to reproduce the manuscript figures
Phenotypic delay in <i>E</i>. <i>coli</i>.
<p>(A) Phenotypic penetrance (mean ± SE; <i>n</i> = 6) over time for three antibiotic resistance mutations. Gray dashed lines: time at 50% phenotypic penetrance. (B) Frequency of homozygous mutants among all mutants (orange) for the three resistance mutations assessed by <i>lacZ</i> reporter constructs (<i>rpoB-lacZ</i>, <i>gyrA-lacZ</i>, <i>rpsL-lacZ</i>), overlaid with their respective phenotypic penetrance. (C) Genotypic mutant frequency for the resistance mutations. (D) Phenotypic penetrance of the lactose prototrophy (<i>rpsL-lacZ</i>) mutation. (E) Colonies founded by homozygous (blue) and heterozygous (sectored) lac<sup>+</sup> mutants. The numerical data for panels A to D can be found in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.2004644#pbio.2004644.s005" target="_blank">S1 Data</a>. MIC, minimum inhibitory concentration.</p
Approximate mutant frequencies at mutation–selection balance.
<p>Ploidy is <i>c</i> = 2<sup><i>n</i></sup> (<i>n</i> ≥ 1) in the polyploid cases, is the per-copy mutation rate, and <i>s</i> is the cost of the mutation in homozygotes (in heterozygotes, the cost is masked in the recessive case but expressed in the dominant case).</p