Effects of Neutral Hydrogen on Cosmic Ray Precursors in Supernova Remnant Shock Waves

Many fast supernova remnant shocks show spectra dominated by Balmer lines. The H$\alpha$ profiles have a narrow component explained by direct excitations and a thermally Doppler broadened component due to atoms that undergo charge exchange in the post-shock region. However, the standard model does not take into account the cosmic-ray shock precursor, which compresses and accelerates plasma ahead of the shock. In strong precursors with sufficiently high densities, the processes of charge exchange, excitation and ionization will affect the widths of both narrow and broad line components. Moreover, the difference in velocity between the neutrals and the precursor plasma gives rise to frictional heating due to charge exchange and ionization in the precursor. In extreme cases, all neutrals can be ionized by the precursor. In this paper we compute the ion and electron heating for a wide range of shock parameters, along with the velocity distribution of the neutrals that reach the shock. Our calculations predict very large narrow component widths for some shocks with efficient acceleration, along with changes in the broad- to-narrow intensity ratio used as a diagnostic for the electron-ion temperature ratio. Balmer lines may therefore provide a unique diagnostic of precursor properties. We show that heating by neutrals in the precursor can account for the observed H$\alpha$ narrow component widths, and that the acceleration efficiency is modest in most Balmer line shocks observed thus far.Comment: 9 pages, 3 figure

The relation between post-shock temperature, cosmic-ray pressure and cosmic-ray escape for non-relativistic shocks

Supernova remnants are thought to be the dominant source of Galactic cosmic rays. This requires that at least 5% of the available energy is transferred to cosmic rays, implying a high cosmic-ray pressure downstream of supernova remnant shocks. Recently, it has been shown that the downstream temperature in some remnants is low compared to the measured shock velocities, implying that additional pressure support by accelerated particles is present. Here we use a two-fluid thermodynamic approach to derive the relation between post-shock fractional cosmic-ray pressure and post-shock temperature, assuming no additional heating beyond adiabatic heating in the shock precursor and with all non-adiabatic heating occurring at the subshock. The derived relations show that a high fractional cosmic-ray pressure is only possible, if a substantial fraction of the incoming energy flux escapes from the system. Recently a shock velocity and a downstream proton temperature were measured for a shock in the supernova remnant RCW 86. We apply the two-fluid solutions to these measurements and find that the the downstream fractional cosmic-ray pressure is at least 50% with a cosmic-ray energy flux escape of at least 20%. In general, in order to have 5% of the supernova energy go into accelerating cosmic rays, on average the post-shock cosmic-ray pressure needs to be 30% for an effective cosmic-ray adiabatic index of 4/3.Comment: 9 pages, 6 color figures. This is updated with a corrected figure 5a and 5b, reflecting an ApJ erratu

Conformational mechanism for the stability of microtubule-kinetochore attachments

Regulating the stability of microtubule(MT)-kinetochore attachments is fundamental to avoiding mitotic errors and ensure proper chromosome segregation during cell division. While biochemical factors involved in this process have been identified, its mechanics still needs to be better understood. Here we introduce and simulate a mechanical model of MT-kinetochore interactions in which the stability of the attachment is ruled by the geometrical conformations of curling MT-protofilaments entangled in kinetochore fibrils. The model allows us to reproduce with good accuracy in vitro experimental measurements of the detachment times of yeast kinetochores from MTs under external pulling forces. Numerical simulations suggest that geometrical features of MT-protofilaments may play an important role in the switch between stable and unstable attachments

Proper Motions of H-alpha filaments in the Supernova Remnant RCW 86

We present a proper motion study of the eastern shock-region of the supernova remnant RCW 86 (MSH 14-63, G315.4-2.3), based on optical observations carried out with VLT/FORS2 in 2007 and 2010. For both the northeastern and southeastern regions, we measure an average proper motion of H-alpha filaments of 0.10 +/- 0.02 arcsec/yr, corresponding to 1200 +/- 200 km/s at 2.5kpc. There is substantial variation in the derived proper motions, indicating shock velocities ranging from just below 700 km/s to above 2200 km/s. The optical proper motion is lower than the previously measured X-ray proper motion of northeastern region. The new measurements are consistent with the previously measured proton temperature of 2.3 +/- 0.3 keV, assuming no cosmic-ray acceleration. However, within the uncertainties, moderately efficient (< 27 per cent) shock acceleration is still possible. The combination of optical proper motion and proton temperature rule out the possibility that RCW 86 has a distance less than 1.5kpc. The similarity of the proper motions in the northeast and southeast is peculiar, given the different densities and X-ray emission properties of the regions. The northeastern region has lower densities and the X-ray emission is synchrotron dominated, suggesting that the shock velocities should be higher than in the southeastern, thermal X-ray dominated, region. A possible solution is that the H-alpha emitting filaments are biased toward denser regions, with lower shock velocities. Alternatively, in the northeast the shock velocity may have decreased rapidly during the past 200yr, and the X-ray synchrotron emission is an afterglow from a period when the shock velocity was higher.Comment: Accepted for publication in MNRA

Inhaled hydrogel-based microspheres for management of COVID-19 : A new sweeper biological platform

The cytokine storm caused by SARS-CoV-2 infection threatens the condition of patients, even leading to death. In a recent issue of Matter, Prof. Wenguo Cui and co-workers have prepared lung-sweeper inhaled hydrogel microspheres for intratracheal neutralization of COVID-19 and cytokine storm calming, which could be applied for antiviral tissue regeneration, drug delivery, and disease diagnosis.Non peer reviewe

Bio-Nanomedicine for Cancer Therapy Preface

Non peer reviewe

Interacting Microsoft Visual Basic Procedures (Macros) and GIS tools in order to access optimal location and maximum use of railways and railway infrastructures

Some parts of the Portuguese railway infrastructure have been neglected through time: Rural lines have been abandoned, investment in new infrastructure is sometimes delayed, and marketing strategies to keep or attract more users have not been pursued. Simultaneously, problems with urban congestion, pollution and mobility for the young, the elderly, the poor, and the handicapped are putting forward the discussion about new or more sustainable modes of transportation. Common sense of public officials, other lobbying groups, and the locals demand new, trendy train lines. And while some axes may have the potential to justify rail lines, others seem to lack population or funding to be enabled. One major problem in order to evaluate the worthiness of these rail projects has been the fact that very often the studies of travel demand and physical implantation are done separately. Travel demand analysis is done based on the four-step model (trip generation, distribution, modal split, and network assignment) using survey data and the network system, using a relatively wide zoning. The importance of interacting with other, finer, information (i.e. slope, density of population, environmental sensitivity, or other socio-economic and land use information) with the development of the travel analysis demand will enhance the analysis/results and increase the chance of proposing lines that are both optimal in location and will have the maximum use by the citizens. Off the shelf software is still unable to perform this kind of operations. Some perform the analysis using existing networks, and no information on the land is available besides the zoning system, other software propose lines accordingly to land slopes, but no trip information is included. GIS packages have the capacity to include the land information and some have some transportation analysis, but are lacking computation capabilities and algorithms to perform analysis similar to off-the-shelf transportation software. In order to develop this kind of integrated analysis it is important to have a good knowledge of the algorithms and analysis required by transportation and of the tools/opportunities offered by the GIS packages. This paper presents a methodology that integrates the transportation algorithms with the GIS functionalities, using excel macro-language. The result is an interaction of both travel demand analysis and site selection. The characteristics of the place constrain the travel demand analysis, but on its own the travel demand analysis define not only the buffer of the train line, but systematically enhance the shape of the line and the location of the stops each time the results of a phase of the travel demand analysis is outputted. This paper offers guidelines for those developing travel demand analysis including some site selection criteria, and it can be a starting point for those of whom intend to develop further application of in the GIS fields.