Understanding cross-country variation in the long-term consequences of graduating at a bad time: A comparison of five European countries

This working paper investigates if graduating in a bad economy scars careers of youth cohorts in terms of increased future unemployment and overrepresentation in fixed-term and involuntary part-time work. These dynamics of scarring are explored from a cross-country comparative perspective, focusing on the UK, Germany, Switzerland, Spain and Finland. These countries make up for interesting cases as they differ remarkably on institutional and economic dimensions such as for example the vocational orientation of their education systems, the strictness of employment protection legislation, active labour market policies to support job-search success of jobless young people and the general level of prevalent youth unemployment, which are assumed to be related to cross-nationally distinct patterns in scarring effects. The focus of the empirical analysis is on long-term effects of the level of aggregate youth unemployment at graduation on career evolvement of school-leaver cohorts over 12 years since their graduation, distinguishing between educational groups while allowing for gender effects. All in all we find that bad luck in timing of labour market entry can scar future careers over the long-run. A bad economy at labour market entry may thus be seen as a major risk factor for the future integration of youth cohorts in very different institutional contexts

Job Insecurity: Differential Effects of Subjective and Objective Measures on Life Satisfaction Trajectories of Workers Aged 27–30 in Germany

Job insecurity has become increasingly evident in European countries in recent years. In Germany, legislation has increased insecurity through erosion of the standard employment relationship. Fixed-term contracts are central to definitions of insecurity based on atypical or precarious work but there is still limited understanding of what creates insecurity and how it affects workers. Drawing on Bourdieu’s thesis that “insecurity is everywhere”, the relationships between subjective and objective measures of insecurity are examined for their impact on the 5-year trajectories of life satisfaction of men and women in the age group 27–30. Latent growth curve analysis of data from the German Socio-Economic Panel for 2010–2014 highlights the adverse and lasting effects of subjective concerns about job insecurity on life satisfaction trajectories. This association cuts across educational groups, with far reaching implications as subjective concerns about job security permeate young worker’s lives well beyond the objective condition of being employed on a fixed-term contract

Ambiguity in European seasonal comparative research: how decisions on modelling shape results on inequality in learning?

Summer break study designs are used in educational research to disentangle school from non-school contributions to social performance gaps. The summer breaks provide a natural experimental setting that allows for the measurement of learning progress when school is not in session, which can help to capture the unfolding of social disparities in learning that are the result of non-school influences. Seasonal comparative research has a longer tradition in the U.S. than in Europe, where it is only at its beginning. As such, summer setback studies in Europe lack a common methodological framework, impairing the possibility to draw lines across studies because they differ in their inherent focus on social inequality in learning progress. This paper calls for greater consideration of the parameterization of “unconditional” or “conditional” learning progress in European seasonal comparative research. Different approaches to the modelling of learning progress answer different research questions. Based on real data and constructed examples, this paper outlines in an intuitive fashion the different dynamics in inequality that may be simultaneously present in the survey data and distinctly revealed depending on whether one or the other modeling strategy of learning progress is chosen. An awareness of the parameterization of learning progress is crucial for an accurate interpretation of the findings and their international comparison

Validation of extracellular ligand–receptor interactions by Flow-TriCEPS

Abstract Objective The advent of ligand-based receptor capture methodologies, allows the identification of unknown receptor candidates for orphan extracellular ligands. However, further target validation can be tedious, laborious and time-consuming. Here, we present a methodology that provides a fast and cost-efficient alternative for candidate target verification on living cells. Results In the described methodology a ligand of interest (e.g. transferrin, epidermal growth factor or insulin) was conjugated to a linker (TriCEPS) that carries a biotin. To confirm ligand/receptor interactions, the ligand–TriCEPS conjugates were first added onto living cells and cells were subsequently labeled with a streptavidin-fluorophore and analyzed by flow cytometry (thus referred as Flow-TriCEPS). Flow-TriCEPS was also used to validate identified receptor candidates when combined with a siRNA knock down approach (i.e. reduction of expression levels). This approach is versatile as it can be applied for different classes of ligands (proteins, peptides, antibodies) and different cell lines. Moreover, the method is time-efficient since it takes advantage of the large variety of commercially available (and certified) siRNAs

A call to action: Antiracist patient engagement in adolescent and young adult oncology research and advocacy

Amidst the concurrent global crises of coronavirus disease 2019 (COVID-19), uprisings against Anti-Black racism and police brutality, as well as anti-Asian racism and violence, the field of medicine found itself simultaneously called upon to respond as essential workers in the public health devastation of COVID-19, and as representatives of healthcare institutions wrought with the impacts of systemic racism. Clinicians, researchers, and advocates in adolescent and young adult (AYA) oncology, must come together in authentic activism to begin the work of creating structural change to advance antiracist approaches to patient engagement in AYA oncology research and advocacy. Critical review of existing practices is needed to ensure that ethical and effective research methods are employed when engaging with racial and ethnic minority AYA patients with cancer, who may be particularly vulnerable and exploited in the current context

BIPOC experiences of (anti-)racist patient engagement in adolescent and young adult oncology research: an electronic Delphi study

To characterize Black, Indigenous and People of Color (BIPOC) adolescent and young adult (AYA) cancer patients' experiences of patient engagement in AYA oncology and derive best practices that are co-developed by BIPOC AYAs and oncology professionals. Following a previous call to action from AYA oncology professionals, a panel of experts composed exclusively of BIPOC AYA cancer patients (n = 32) participated in an electronic Delphi study. Emergent themes described BIPOC AYA cancer patients' direct experiences and consensus opinion on recommendations to advance antiracist patient engagement from BIPOC AYA cancer patients and oncology professionals. The findings reveal high-priority practices across all phases of research and are instructional for advancing health equity