232 research outputs found
Towards a better understanding of fire performance assessment of façade systems: Current situation and a proposed new assessment framework
This manuscript presents tools and data that serve to enable an evaluation of the risk associated with vertical fire spread on buildings. A highly detailed context to cladding fires is described to unveil the complexity and magnitude of the problem and to identify gaps of information. An engineering framework is then developed which delivers required information that fills some of those gaps and that needs to be used towards achieving quantified fire performance. The data itself has been published as a publicly available database, entitled the Cladding Materials Library (www.claddingmaterialslibrary.com.au). This data can be used to support building fire risk assessments or as the basis for more in-depth research into façade fires. This paper presents the context of the data together with the competency framework necessary for upskilling building professionals to have the capacity to implement the engineering framework
Behavior of FRP confined ultra-high strength concrete columns under compression: An experimental study
Ultra High-Strength Concrete (UHSC) have become increasingly popular within the civil engineering community. While many studies exist on structural members made using UHSC, research works on the behavior of Fiber Reinforced Polymer (FRP) confined UHSC columns are scarce. Existing theoretical models for predicting the behavior of FRP-confined normal strength and high strength concrete found to be inadequate for FRP-confined UHSC with silica fume. Due to inconstancies of existing limited experimental results on FRP-confined UHSC columns, effect of silica fume cannot be clearly identified. This paper presents an experimental study on the compressive performance of twelve FRP-confined UHSC columns under axial compression. The variables investigated include unconfined concrete strength (two different mix designs with different silica fume content) and number of GFRP plies. While GFRP confinement significantly enhance both compressive strength and ultimate strain, effectiveness of GFRP confinement was found to be largely effected by the concrete mix design
Presence of a novel epithelial antigen on rat cerebellar cell lines as detected by a monoclonal antibody
We have derived a monoclonal antibody, MCAb 51, following immunization of BALB/c mice with a Rous sarcoma virus-transformed rat cerebellar cell line. When assayed by immunofluorescence on primary rat cerebellar cultures MCAb 51 recognizes only islands of cells with an epitheloid morphology. Double-label immunofluorescence experiments with MCAb 51 and antisera to tetanus toxin, glial fibrillary acidic protein, galactocerebroside and fibronectin reveal that these cells do not appear to be neurons, astrocytes, oligodendrocytes, or fibroblasts, respectively. In contrast, cells from kidney, liver, tongue and choroid plexus epithelium are positive for the antigen. Of 12 Rous sarcoma virus-transformed cell lines, in contrast to 2 out of 9 chemically transformed lines, 11 exhibit the MCAb 51 antigen. These findings demonstrate that MCAb 51 recognizes an epithelial cell surface marker. Possible explanations for the difference in the expression of the antigen on Rous sarcoma virus and chemically transformed neural lines are discussed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/25625/1/0000175.pd
Towards a better understanding of fire performance assessment of façade systems: current situation and a proposed new assessment framework
This manuscript presents tools and data that serve to enable an evaluation of the risk associated with vertical fire spread on buildings. A highly detailed context to cladding fires is described to unveil the complexity and magnitude of the problem and to identify gaps of information. An engineering framework is then developed which delivers required information that fills some of those gaps and that needs to be used towards achieving quantified fire performance. The data itself has been published as a publicly available database, entitled the Cladding Materials Library (www.claddingmaterialslibrary.com.au). This data can be used to support building fire risk assessments or as the basis for more in-depth research into façade fires. This paper presents the context of the data together with the competency framework necessary for upskilling building professionals to have the capacity to implement the engineering framework
The Obliquity of HIP 67522 b: A 17 Myr Old Transiting Hot, Jupiter-sized Planet
HIP 67522 b is a 17 Myr old, close-in (P orb = 6.96 days), Jupiter-sized (R = 10 R ⊕) transiting planet orbiting a Sun-like star in the Sco-Cen OB association. We present our measurement of the system's projected orbital obliquity via two spectroscopic transit observations using the CHIRON spectroscopic facility. We present a global model that accounts for large surface brightness features typical of such young stars during spectroscopic transit observations. With a value of | λ | = 5.8-5.7+2.8 it is unlikely that this well-aligned system is the result of a high-eccentricity-driven migration history. By being the youngest planet with a known obliquity, HIP 67522 b holds a special place in contributing to our understanding of giant planet formation and evolution. Our analysis shows the feasibility of such measurements for young and very active stars
Phase II study of capecitabine and oxaliplatin given prior to and concurrently with preoperative pelvic radiotherapy in patients with locally advanced rectal cancer
This multicentre phase II study evaluated the efficacy and safety of preoperative capecitabine plus oxaliplatin and radiotherapy (RT) in patients with locally advanced rectal cancer (T3/T4 rectal adenocarcinoma with or without nodal involvement). Treatment consisted of one cycle of XELOX (capecitabine 1000 mg m−2 bid on days 1–14 and oxaliplatin 130 mg m−2 on day 1), followed by RT (1.8 Gy fractions 5 days per week for 5 weeks) plus CAPOX (capecitabine 825 mg m−2 bid on days 22–35 and 43–56, and oxaliplatin 50 mg m−2 on days 22, 29, 43 and 50). Surgery was recommended 5 weeks after completion of chemoradiotherapy. The primary end point was pathological complete tumour response (pCR). Sixty patients were enrolled. In the intent-to-treat population, the pCR rate was 23% (95% CI: 13–36%). 58 patients underwent surgery; R0 resection was achieved in 57 (98%) patients, including all 5 patients with T4 tumours. Sphincter preservation was achieved in 49 (84%) patients. Tumour and/or nodal downstaging was observed in 39 (65%) patients. The most common grade 3/4 adverse events were diarrhoea (20%) and lymphocytopaenia (43%). Preoperative capecitabine, oxaliplatin and RT achieved encouraging rates of pCR, R0 resection, sphincter preservation and tumour downstaging in patients with locally advanced rectal cancer
Pharmacological Characterization of FE 202158, a Novel, Potent, Selective, and Short-Acting Peptidic Vasopressin V 1a Receptor Full Agonist for the Treatment of Vasodilatory Hypotension
ABSTRACT R), and oxytocin receptor, respectively] contrasting with AVP's lack of selectivity, especially versus the V 2 R (selectivity ratio of 1:18:0.2:92; human V 1a R EC 50 Ï 0.24 nM). This activity and selectivity profile was confirmed in radioligand binding assays. FE 202158 was a potent vasoconstrictor in the isolated rat common iliac artery ex vivo (EC 50 Ï 3.6 nM versus 0.8 nM for AVP) and reduced rat ear skin blood flow after intravenous infusion in vivo (ED 50 Ï 4.0 versus 3.4 pmol/kg/min for AVP). The duration of its vasopressor effect by intravenous bolus in rats was as short as AVP at submaximally effective doses. FE 202158 had no V 2 R-mediated antidiuretic activity in rats by intravenous infusion at its ED 50 for reduction of ear skin blood flow, in contrast with the pronounced antidiuretic effect of AVP. Thus, FE 202158 seems suitable for treatment of conditions where V 1a R activity is desirable but V 2 R activity is potentially deleterious, such as vasodilatory hypotension in septic shock. In addition to the desirable selectivity profile, its shortacting nature should allow dose titration with rapid onset and offset of action to optimize vasoconstriction efficacy and safety
CHEOPS observations of KELT-20 b/MASCARA-2 b: An aligned orbit and signs of variability from a reflective dayside
Occultations are windows of opportunity to indirectly peek into the dayside
atmosphere of exoplanets. High-precision transit events provide information on
the spin-orbit alignment of exoplanets around fast-rotating hosts. We aim to
precisely measure the planetary radius and geometric albedo of the ultra-hot
Jupiter (UHJ) KELT-20 b as well as the system's spin-orbit alignment. We
obtained optical high-precision transits and occultations of KELT-20 b using
CHEOPS observations in conjunction with the simultaneous TESS observations. We
interpreted the occultation measurements together with archival infrared
observations to measure the planetary geometric albedo and dayside
temperatures. We further used the host star's gravity-darkened nature to
measure the system's obliquity. We present a time-averaged precise occultation
depth of 82(6) ppm measured with seven CHEOPS visits and 131(+8/-7) ppm from
the analysis of all available TESS photometry. Using these measurements, we
precisely constrain the geometric albedo of KELT-20 b to 0.26(0.04) and the
brightness temperature of the dayside hemisphere to 2566(+77/-80) K. Assuming
Lambertian scattering law, we constrain the Bond albedo to 0.36(+0.04/-0.05)
along with a minimal heat transfer to the night side. Furthermore, using five
transit observations we provide stricter constraints of 3.9(1.1) degrees on the
sky-projected obliquity of the system. The aligned orbit of KELT-20 b is in
contrast to previous CHEOPS studies that have found strongly inclined orbits
for planets orbiting other A-type stars. The comparably high planetary
geometric albedo of KELT-20 b corroborates a known trend of strongly irradiated
planets being more reflective. Finally, we tentatively detect signs of temporal
variability in the occultation depths, which might indicate variable cloud
cover advecting onto the planetary day side.Comment: 27 pages, 15 figures, Accepted for publication in Astronomy &
Astrophysic
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