116 research outputs found
SĂndrome de Stevens-Johnson. Apresentação de Caso ClĂnico
Introdução: A SĂndrome de Stevens-Johnson (SSJ) Ă© uma doença mucocutĂąnea rara e potencialmente fatal, mais frequente no sexo masculino, cuja incidĂȘncia aumenta com a idade e em determinados grupos de risco. A SSJ e a NecrĂłlise TĂłxica EpidĂ©rmica (NET) sĂŁo duas entidades da mesma doença, com severidade diferente. A etiologia nĂŁo Ă© clara, mas pensa-se que se deva maioritariamente a reacçÔes adversas a fĂĄrmacos.
Caso clĂnico: Um jovem de 17 anos de idade, sem antecedentes pessoais relevantes, foi observado no Serviço de UrgĂȘncia por surgimento de lesĂ”es maculopapulares, com 3 dias de evolução, dispersas pela face, cavidade oral, tronco e extremidades, com prostração e taquicardia. Foi internado com o diagnĂłstico de SSJ.
DiscussĂŁo e ConclusĂ”es: O SSJ e a NET tĂȘm grande morbilidade e considerĂĄvel mortalidade. O rĂĄpido reconhecimento desta identidade, com a remoção do fĂĄrmaco desencadeador Ă© essencial. A perda da função de barreira da pele, com a consequente alteração da homeostasia, implica muitas vezes a manutenção da terapĂȘutica de suporte em Unidades de Cuidados Intensivos ou de Queimados.info:eu-repo/semantics/publishedVersio
Mesenchymal Stem Cell-Mediated Functional Tooth Regeneration in Swine
Mesenchymal stem cell-mediated tissue regeneration is a promising approach for regenerative medicine for a wide range of applications. Here we report a new population of stem cells isolated from the root apical papilla of human teeth (SCAP, stem cells from apical papilla). Using a minipig model, we transplanted both human SCAP and periodontal ligament stem cells (PDLSCs) to generate a root/periodontal complex capable of supporting a porcelain crown, resulting in normal tooth function. This work integrates a stem cell-mediated tissue regeneration strategy, engineered materials for structure, and current dental crown technologies. This hybridized tissue engineering approach led to recovery of tooth strength and appearance
Morphometric study of the root anatomy in furcation area of mandibular first molars
Furcation involvement in periodontal disease has been a challenge for the dentist. OBJECTIVE: The aim of this study was to investigate root dimensions in the furcation area of 233 mandibular first molars. MATERIAL AND METHODS: Digital photomicrographs were used to obtain the following measurements on the buccal and lingual surfaces of each tooth: root trunk height (RT), horizontal interadicular distance obtained 1 mm (D1) and 2 mm (D2) below the fornix and interadicular angle (IA). RESULTS: Mean± standard deviation of buccal and lingual furcation measurements were, respectively, 1.37±0.78 mm and 2.04±0.89 mm for RT; 0.86±0.39 mm and 0.71±0.42 mm for D1; 1.50±0.48 mm and 1.38±0.48 mm for D2; 41.68±13.20Âș and 37.78±13.18Âș for IA. Statistically significant differences were found between all measured parameters for buccal and lingual sides (p<0.05, paired t test). CONCLUSIONS: In conclusion, the lingual furcation of mandibular first molars presented narrower entrance and longer root trunk than the buccal furcation, suggesting more limitation for instrumentation and worse prognosis to lingual furcation involvements in comparison to buccal lesions
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