Differential treatment of bipolar disorder with old and new antiepileptic drugs

Although lithium remains the preferred medication for bipolar disorders, new investigations suggest that only 60 to 80% of patients have a good response with a classical presentation. The antiepileptics carbamazepine and valproate are important alternatives. Several studies have shown that lithium, carbamazepine and valproate are effective in pure mania. Mixed mania and rapid cycling respond, however, well to valproate. One disadvantage of carbamazepine is its enzyme inducing property with the consequence of a decrease of plasma levels of other psychotropic medications and a worsening of psychopathology. First data indicate a good antimanic and antidepressive efficacy of the new antiepileptic drug lamotrigine

Simulator evaluation of the final approach spacing tool

The design and simulator evaluation of an automation tool for assisting terminal radar approach controllers in sequencing and spacing traffic onto the final approach course is described. The automation tool, referred to as the Final Approach Spacing Tool (FAST), displays speed and heading advisories for arrivals as well as sequencing information on the controller's radar display. The main functional elements of FAST are a scheduler that schedules and sequences the traffic, a 4-D trajectory synthesizer that generates the advisories, and a graphical interface that displays the information to the controller. FAST was implemented on a high performance workstation. It can be operated as a stand-alone in the Terminal Radar Approach Control (TRACON) Facility or as an element of a system integrated with automation tools in the Air Route Traffic Control Center (ARTCC). FAST was evaluated by experienced TRACON controllers in a real-time air traffic control simulation. Simulation results show that FAST significantly reduced controller workload and demonstrated a potential for an increase in landing rate

New insights into the mechanisms and sites of action of lamotrigine

This study was aimed at investigating the effects of lamotrigine (LTG) on electrically evoked field excitatory postsynaptic potentials (fEPSP) and population spikes in the CA1 hippocampal region of guinea pigs. The concentration response curves showed different actions of LTG on fEPSP and on population spikes. The data are in contrast to previous findings that suggest the drug acts primarily on presynaptic sites via a blockade of the release of excitatory amino acids, In the range of therapeutic plasma levels, synaptic transmission was not affected. Copyright (C) 2000 S. Karger AG, Basel

Hadron production from quark coalescence and jet fragmentation in intermediate energy collisions at RHIC

Transverse momentum spectra of pions, protons and antiprotons in Au+Au collisions at intermediate RHIC energy of $\sqrt{s_{NN}}=62$ GeV are studied in a model that includes both quark coalescence from the dense partonic matter and fragmentation of the quenched perturbative minijet partons. The resulting baryon to meson ratio at intermediate transverse momenta is predicted to be larger than that seen in experiments at higher center of mass energies.Comment: 6 pages, 2 figures. Figures replaced to differentially address the high-pT behavior of baryon versus antibaryon to meson ratio

Flow effects on the freeze-out phase-space density in heavy ion collisions

The strong longitudinal expansion of the reaction zone formed in relativistic heavy-ion collisions is found to significantly reduce the spatially averaged pion phase-space density, compared to naive estimates based on thermal distributions. This has important implications for data interpretation and leads to larger values for the extracted pion chemical potential at kinetic freeze-out.Comment: 5 pages, 3 figures included via epsfig, added discussion of different transverse density profiles, 1 new figur

Speech Communication

Contains reports on two research projects.United States Air Force, Cambridge Research Center, Air Research and Development Command (Contract AF19(604)-6102)National Science Foundation (Grant G-10800 and Grant G-16526)National Institutes of Health (Grant MH-04737-02