START BLOCK KINETICS: WHAT THE BEST DO DIFFERENT THAN THE REST

The purpose of this study was to analyze the push – off forces of male and female sprinters from a wide range of performance levels, including the currently two fastest sprinters in the world. A force start block was used to measure the forces applied to the front and rear blocks. In total, 430 full effort starts of over 99 subjects were analyzed. World – class athletes did not leave the blocks with a higher center of mass velocity, but with a shorter block time. They were able to produce higher maximum forces and rates of force development. Maximum forces were more balanced between the front and rear leg. These results further highlight the importance of high force capacities for a successful sprint start. The more evenly distributed maximum forces of the front and rear leg of world – class athletes might be a technical feature that could help lower level athletes to improve their performance. Training success should be monitored using force measurements in the blocks

JOINT SPECIFIC CONTRIBUTION OF MECHANICAL POWER AND WORK DURING ACCELERATION AND TOP SPEED IN ELITE SPRINTERS

The purpose of the study was to quantify and compare sprint mechanics of elite female sprinters (N=9; PB 11.4?0.2s) during acceleration (1st, 2nd, 3rd step) and top speed (‘flying 30m) running. Three dimensional kinetics and kinematics were measured on an IAAF indoor track armed with four force plates and 16 cameras. The comparison between the 1st, 2nd and 3rd step and the ‘flying 30m’ (vave= 9.0?0.2 ms-1) shows a progressive change in absorption and generation of mechanical power. Whilst the knee extensors where able to minimize energy absorption during acceleration, the ankle extensors showed a stretch-shortening cycle and a small absorption from the first step. This energy loss at the ankle joint does not necessarily leads to a decrease in sprint performance, it also offers the plantar flexors to work in an stretch-shortening cycle instead of concentric only mode

SPRINT START KINETICS: COMPARISON OF AMPUTEE AND NON-AMPUTEE SPRINTERS

The purpose of this study was to observe relationships between reaction forces measured with an instrumented force starting block, start performance (normalized average horizontal block power) and 100 m personal record times in 142 male and female able-bodied sprinters. Further, start kinetics of 7 amputee sprinters and ablebodied sprinters of similar 100 m performance level were compared. Amputee sprinters showed a reduced starting performance, which seems to be related to their lower capacity of creating high peak forces with their rear (affected) legs. In able-bodied athletes, starting performance was related to peak force production in the front and rear blocks, but also to the ability to apply these forces in a horizontal direction. The obtained dataset offers a strong potential for the use in performance diagnostics and feedback training

Формирование интегрированной системы менеджмента качества на предприятии

Объектом исследования является система менеджмента качества ООО "Томскводоканал". Цель: разработка рекомендаций по созданию и внедрению интегрированной системы менеджмента В процессе исследования проводились: ?Анализ литературных источников по теме ВКР. ?Изучение нормативно-методической базы для разработки документации. ?Анализ систем менеджмента ООО "Томскводоканал". ?Изучение специфики требований стандарта ISO 18000:2007. ?Изучение специфики требований стандарта ISO 14000:2015. -- Создание рекомендации по разработке и внедрению интегрированной системы менеджмента.Object of a research is the quality management system of LLC Tomskvodokanal. Purpose: development of recommendations about creation and introduction of the integrated system of management In the course of the research were carried out: ? The analysis of references on subject VKR. ? Studying of standard and methodical base for development of documentation. ? Analysis of systems of management of LLC Tomskvodokanal. ? Studying of specifics of requirements of ISO 18000:2007. ? Studying of specifics of requirements of ISO 14000:2015. - Creation of the recommendation about development and deployment of the integrated system of management

Safety and Efficacy of Laparoscopic Colposuspension

Objective:The aim of the study is to determine the effectiveness of the laparoscopic colposuspension in the treatment of urinary stress incontinence. The secondary purpose is to define the place of the intervention among the contemporary methods for the treatment of the disease. Material and methods: We conducted a prospective single arm observational study between April 1993 and April 2000. All patients participated following a written informed consent. The patients included in this biggest study ever, suffered of urinary stress incontinence or mixed incontinence and we used the laparoscopic colposuspension for the treatment of the disorder. The cure rate was evaluated objectively based on personal examination, and subjectively using an “Incontinence Questionnaire”, filled out by the patients postoperatively. Results: Out of 312 patients, 7.2% had preoperatively a USI I (urinary stress incontinence grade I), 23.1% a USI II and 69.7% a USI III. Mixed incontinence was observed in 41.1% of the patients and preoperative recurrent incontinence in 17.6% of them. The laparoscopic colposuspension alone was performed in 131 cases and combined with other surgical interventions in 181 patients. The cure rates achieved in our study were 86.4% in primary incontinence and 62.5% in the recurrent urinary incontinence. The overall complication rate was 11.2% with 6% major complications. Conclusions: The high cure rates obtained in this study, sustained by the literature results, support the further recommendation of the laparoscopic colposuspension in the treatment of urinary stress incontinence as a primary as well as an alternative operative technique

FeCoCp3 Molecular Magnets as Spin Filters

Metallorganic molecules have been proposed as excellent spin filters in molecular spintronics because of the large spin-polarization of their electronic structure. However, most of the studies involving spin transport, have disregarded fundamental aspects such as the magnetic anisotropy of the molecule and the excitation of spin-flip processes during electron transport. Here, we study a molecule containing a Co and an Fe atoms stacked between three cyclopentadienyl rings that presents a large magnetic anisotropy and a S=1. These figures are superior to other molecules with the same transition metal, and improves the spin-filtering capacities of the molecule. Non-equilibrium Green's functions calculations based on density functional theory predict excellent spin-filtering properties both in tunnel and contact transport regimes. However, exciting the first magnetic state drastically reduces the current's spin polarization. Furthermore, a difference of temperature between electrodes leads to strong thermoelectric effects that also suppress spin polarization. Our study shows that in-principle good molecular candidates for spintronics need to be confronted with inelastic and thermoelectric effects

Narrative-based computational modelling of the Gp130/JAK/STAT signalling pathway.

BACKGROUND: Appropriately formulated quantitative computational models can support researchers in understanding the dynamic behaviour of biological pathways and support hypothesis formulation and selection by "in silico" experimentation. An obstacle to widespread adoption of this approach is the requirement to formulate a biological pathway as machine executable computer code. We have recently proposed a novel, biologically intuitive, narrative-style modelling language for biologists to formulate the pathway which is then automatically translated into an executable format and is, thus, usable for analysis via existing simulation techniques. RESULTS: Here we use a high-level narrative language in designing a computational model of the gp130/JAK/STAT signalling pathway and show that the model reproduces the dynamic behaviour of the pathway derived by biological observation. We then "experiment" on the model by simulation and sensitivity analysis to define those parameters which dominate the dynamic behaviour of the pathway. The model predicts that nuclear compartmentalisation and phosphorylation status of STAT are key determinants of the pathway and that alternative mechanisms of signal attenuation exert their influence on different timescales. CONCLUSION: The described narrative model of the gp130/JAK/STAT pathway represents an interesting case study showing how, by using this approach, researchers can model biological systems without explicitly dealing with formal notations and mathematical expressions (typically used for biochemical modelling), nevertheless being able to obtain simulation and analysis results. We present the model and the sensitivity analysis results we have obtained, that allow us to identify the parameters which are most sensitive to perturbations. The results, which are shown to be in agreement with existing mathematical models of the gp130/JAK/STAT pathway, serve us as a form of validation of the model and of the approach itself

Metabolic pathway and distribution of superparamagnetic iron oxide nanoparticles: in vivo study

Experimental tissue fusion benefits from the selective heating of superparamagnetic iron oxide nanoparticles (SPIONs) under high frequency irradiation. However, the metabolic pathways of SPIONs for tissue fusion remain unknown. Hence, the goal of this in vivo study was to analyze the distribution of SPIONs in different organs by means of magnetic resonance imaging (MRI) and histological analysis after a SPION-containing patch implantation