109 research outputs found
Mobile Business in the Vending Industry
The business of operating vending machines substantially changes by the use of telemetry via wireless technologies. This technology enables operators to change their business processes from a fixed periodical to a needs-based operating and maintenance, generating efficiency and effectiveness added values. In addition, significant advantages can be achieved by real-time error reports, by analyzing and optimizing the product range and the profitability. The paper provides a general introduction in the vending market and the operating process. Based on this, drawbacks and opportunities of the use of mobile communication techniques in vending machines for a business process reengineering are discussed and criteria for the choice of telemetry-equipped vending machinesâ locations are developed. The feasibility of the proposed concepts is examined with regard to the current technical state-of-the-art. Finally, conclusions are drawn and an outlook on the future of mobile vending is given.mobile business; mobile business processes; mobile BPR; vending industry; telemetry
Mobile Vending - Benefit and limits of vending machines by using telemetry
The use of telemetry via wireless communication technique is able to support the process of operating vending machines. The advantages on appropriate kinds of vending machines can be achieved by using a demand-driven instead of a trigger-driven provisioning as well as a trouble-shooting in real time. The availability of reliable telemetrically collected real time data enhance the analysis and optimization of the supply in vending machines and the profitability of vending machine places, too. Furthermore, this article shows criteria for the choice of right vending machine places for the use of telemetry as well as current telemetry modules and their significant weaknesses. The article concludes with conceptual proposals and shapes an exemplary picture of Mobile Vending with full usage of the mobile business processesâ potential.
Lymphangiogenese- und Proliferationsmarker: Assoziation mit histopathologischen Merkmalen und Krankheitsverlauf beim Harnblasenkarzinom nach radikaler Zystektomie
Lymphogene Metastasierung und Tumorproliferation des muskelinvasiven Urothelkarzinoms der Harnblase nach radikaler operativer und multimodaler Therapie sind von entscheidender Bedeutung fuÌr Rezidive und MortalitaÌt. Eine LymphgefaÌĂinvasion zum Operationszeitpunkt ist ein wichtiger Risikofaktor und macht Schwierigkeiten in der perioperativen Diagnostik. Die Zielsetzung der vorliegenden Arbeit war es, diagnostischen und prognostischen Stellenwert von Lymphangiogenese- und Proliferationmarkern auf mRNA Ebene nach radikaler Zystektomie zu untersuchen. DafuÌr wurde retrospektiv die Genexpression von Marker of Proliferation Ki67 (MKI67), Rac GTPase Activating Protein 1 (RACGAP1), Vascular Endothelial Growth Factor Receptor-3 (VEGFR-3), Vascular Endothelial Growth Factor-C (VEGF-C) und Vascular Endothelial Growth Factor-D (VEGF-D) mittels quantitativer Polymerasekettenreaktion an repraÌsentativen Fresh Forzen Paraffin Embedded (FFPE) Tumorgewebsschnitten von 108 Patienten nach radikaler Zystektomie untersucht. Von der Patientenkohorte wurde ein Follow-Up erstellt. Die Genexpression der untersuchten Biomarker wurde mit klinischen und histopathologischen Parametern korreliert und die Bedeutung fuÌr den weiteren Krankheitsverlauf der Patienten in uni- und multivariaten Analysen herausgearbeitet. Die Expression von MKI67, RACGAP1, VEGFR-3, VEGF-C war signifikant mit hoÌheren T-Stadien assoziiert. MKI67 war in high-grade (G3) Tumoren signifikant hoÌher exprimiert als in low-grade (G1/G2) Tumoren. Die VEGFR-3 Expression war signifikant mit dem Vorhandensein einer LymphgefaÌĂinvasion und Lymphknotenmetastasen assoziiert. VEGFR-3 war in der univariaten Analyse signifikant mit einem reduzierten krankheitsspezifischen UÌberleben assoziiert. Die multivariate Analyse identifizierte T- Stadium und LymphgefaÌĂinvasion als unabhaÌngige PraÌdiktoren fuÌr ein reduziertes krankheitsspezifisches UÌberleben. Als unabhaÌngige PraÌdiktoren fuÌr ein reduziertes GesamtuÌberleben konnten ein hohes T Stadium und LymphgefaÌĂinvasion, sowie eine niedrige VEGF-D Expression identifiziert werden. Die Proliferationsmarker MKI67 und RACGAP1 sowie VEGF-C waren ohne prognostische Relevanz. Die vorliegenden Ergebnisse unterstuÌtzen die Annahme, dass Lymphangiogenesemarker wie VEGFR-3 auch beim Harnblasenkarzinom eine Rolle bei der lymphogenen Mikrometastasierung spielen. Zudem stellen sie einen Baustein zur objektiven Risikostratifizierung nach radikaler Zystektomie dar. Die gewonnen Erkenntnisse hinsichtlich der Expression von VEGF-D zeigen den hier weiter bestehenden Forschungsbedarf an. Die mRNA- Genexpressionsanalyse von Proliferationsmarkern wie MKI67 koÌnnte im Sinne eines molekularen Gradings in Betracht gezogen werden. Um das Potential der Untersuchung von MKI67 auf mRNA- Ebene als ErgaÌnzung zur Immunhistochemie besser beurteilen zu koÌnnen, sind weitere Forschungsprojekte noÌtig
Perceived Effects of Ballet and Movement-Based Interventions for Parkinsonâs Disease
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Mobile Business in the Vending Industry
The business of operating vending machines substantially changes by the use of telemetry via wireless technologies. This technology enables operators to change their business processes from a fixed periodical to a needs-based operating and maintenance, generating efficiency and effectiveness added values. In addition, significant advantages can be achieved by real-time error reports, by analyzing and optimizing the product range and the profitability. The paper provides a general introduction in the vending market and the operating process. Based on this, drawbacks and opportunities of the use of mobile communication techniques in vending machines for a business process reengineering are discussed and criteria for the choice of telemetry-equipped vending machinesâ locations are developed. The feasibility of the proposed concepts is examined with regard to the current technical state-of-the-art. Finally, conclusions are drawn and an outlook on the future of mobile vending is given
Vergleichende Betrachtung der hydrologischen Eigenschaften typischer Waldhumusauflagen auf Kippenböden und âgewachsenenâ Standorten des Nordostdeutschen Tieflandes
Es erfolgte eine Charakterisierung der hydrologischen Eigenschaften (pF/WG-Funktionen) von Waldhumusauflagen und Mineralböden typischer Kippenstandorte des Lausitzer Braunkohlenbergbaus und vergleichend dazu âgewachsenerâ Standorte im Tagebauumfeld. Zur Bearbeitung standen flĂ€chenreprĂ€sentative Kiefernstangen- und -Baumhölzer sowie Rot- und TraubeneichenbestĂ€nde. Die Wasserspei-chereigenschaften von Of- und Oh-Lagen unterscheiden sich markant, mit sehr viel höherer nFK in den Oh-Lagen. DarĂŒber hinaus steigt die nFK der Oh-Horizonte von Kiefernstandorten mit zunehmendem Bestandesalter von ca. 25 Vol-% auf ĂŒber 30 Vol-% an. Die höchsten Werte mit bis zu 45 Vol-% weisen Oh-Horizonte unter Eiche auf. Zwar ist die nFK der Humusauflagen von Kippenstandorten geringfĂŒgig niedriger als auf âgewachsenenâ Böden, gleichwohl trĂ€gt der Auflagehumus auf Kippenstandorten wegen der dort geringeren nFK des Mineralbodens stĂ€rker zur gesamten nutzbaren WasserspeicherkapazitĂ€t (nWSK) bei
Minimally invasive reconstruction of lateral tibial plateau fractures using the jail technique: a biomechanical study
BACKGROUND: This study described a novel, minimally invasive reconstruction technique of lateral tibial plateau fractures using a three-screw jail technique and compared it to a conventional two-screw osteosynthesis technique. The benefit of an additional screw implanted in the proximal tibia from the anterior at an angle of 90° below the conventional two-screw reconstruction after lateral tibial plateau fracture was evaluated. This new method was called the jail technique. METHODS: The two reconstruction techniques were tested using a porcine model (nâ=â40). Fracture was simulated using a defined osteotomy of the lateral tibial plateau. Load-to-failure and multiple cyclic loading tests were conducted using a material testing machine. Twenty tibias were used for each reconstruction technique, ten of which were loaded in a load-to-failure protocol and ten cyclically loaded (5000 times) between 200 and 1000 N using a ramp protocol. Displacement, stiffness and yield load were determined from the resulting load displacement curve. Failure was macroscopically documented. RESULTS: In the load-to-failure testing, the jail technique showed a significantly higher mean maximum load (2275.9 N) in comparison to the conventional reconstruction (1796.5 N, pâ<â0.001). The trend for better outcomes for the novel technique in terms of stiffness and yield load did not reach statistical significance (pâ>â0.05). In cyclic testing, the jail technique also showed better trends in displacement that were not statistically significant. Failure modes showed a tendency of screws cutting through the bone (cut-out) in the conventional reconstruction. No cut-out but a bending of the lag screws at the site of the additional third screw was observed in the jail technique. CONCLUSIONS: The results of this study indicate that the jail and the conventional technique have seemingly similar biomechanical properties. This suggests that the jail technique may be a feasible alternative to conventional screw osteosynthesis in the minimally invasive reconstruction of lateral tibial plateau fractures. A potential advantage of the jail technique is the prevention of screw cut-outs through the cancellous bone
Mobile Vending - Nutzen und Grenzen des Telemetrieeinsatzes bei Warenautomaten
The use of telemetry via wireless communication technique is able to support the process of operating vending machines. The advantages on appropriate kinds of vending machines can be achieved by using a demand-driven instead of a trigger-driven provisioning as well as a trouble-shooting in real time. The availability of reliable telemetrically collected real time data enhance the analysis and optimization of the supply in vending machines and the profitability of vending machine places, too. Furthermore, this article shows criteria for the choice of right vending machine places for the use of telemetry as well as current telemetry modules and their significant weaknesses. The article concludes with conceptual proposals and shapes an exemplary picture of Mobile Vending with full usage of the mobile business processesâ potential
ANLN and TLE2 in Muscle Invasive Bladder Cancer: A Functional and Clinical Evaluation Based on In Silico and In Vitro Data
Anilin actin binding protein (ANLN) and transducing-like enhancer protein 2 (TLE2) are associated with cancer patient survival and progression. The impact of their gene expression on progression-free survival (PFS) of patients with muscle invasive bladder cancer (MIBC) treated with radical cystectomy (RC) and subtype association has not yet been investigated. qRT-PCR was used to measure the transcript levels of ANLN and TLE2 in the Mannheim cohort, and validated in silico by The Cancer Genome Atlas (TCGA) cohort. Uni- and multivariate Cox regression analyses identified predictors for disease-specific survival (DSS) and overall survival (OS). In the Mannheim cohort, tumors with high ANLN expression were associated with lower OS and DSS, while high TLE2 expression was associated with a favorable OS. The TCGA cohort confirmed that high ANLN and low TLE2 expression was associated with shorter OS and disease-free survival (DFS). In both cohorts, multivariate analyses showed ANLN and TLE2 expression as independent outcome predictors. Furthermore, ANLN was more highly expressed in cell lines and patients with the basal subtype, while TLE2 expression was higher in cell lines and patients with the luminal subtype. ANLN and TLE2 are promising biomarkers for individualized bladder cancer therapy including cancer subclassification and informed MIBC prognosis
Hydrologische Eigenschaften typischer Waldhumusformen unter Gemeiner Kiefer im NordostsÀchsischen Tiefland: Wasserspeicherung - Hydrophobie - Versickerung
Labor- und Felduntersuchungen zum Infiltrationsverhalten des Auflagehumus eines bestockungstypischen Reinbestandes aus Gemeiner Kiefer erlauben eine nÀhere Kennzeichnung seiner hydrologischen Funktionen.
WĂ€hrend in der Vegetationsperiode 2014 eine mehrmalige Wiederbefeuchtung des Auflagehumus und Zwischenspeicherung auftritt, bleibt dieser im niederschlagsreicheren Folgejahr fast ĂŒber die gesamte Vegetationsperiode trocken. Hier verzögert eine im FrĂŒhsommer induzierte Hydrophobie die Wiederbefeuchtung. Selbst nach StarkniederschlĂ€gen findet bis in den Winter keine nennenswerte Wasserspeicherung mehr statt.
Gleichwohl wird die Humusauflage wegen ihres sehr hohen Gesamtporenvolumens ungehindert durchsickert, was zur wiederholten AufsĂ€ttigung des oberen Mineralbodens in der Vegetationszeit fĂŒhrt
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