20 research outputs found
Using Light Charged Particles to Probe the Asymmetry Dependence of the Nuclear Caloric Curve
Recently, we observed a clear dependence of the nuclear caloric curve on
neutron-proton asymmetry through examination of fully
reconstructed equilibrated quasi-projectile sources produced in heavy ion
collisions at E/A = 35 MeV. In the present work, we extend our analysis using
multiple light charged particle probes of the temperature. Temperatures are
extracted with five distinct probes using a kinetic thermometer approach.
Additionally, temperatures are extracted using two probes within a chemical
thermometer approach (Albergo method). All seven measurements show a
significant linear dependence of the source temperature on the source
asymmetry. For the kinetic thermometer, the strength of the asymmetry
dependence varies with the probe particle species in a way which is consistent
with an average emission-time ordering.Comment: 7 pages, 4 figure
O campo de estudos socioantropológicos sobre diversidade sexual e de gênero no Brasil: ensaio sobre sujeitos, temas e abordagens
Combined treatment with low-dose methotrexate and initial short-term superpotent topical steroids in bullous pemphigoid: an open, multicentre, retrospective study
Regulation by CRAMP of the responses of murine peritoneal macrophages to extracellular ATP.
Peritoneal macrophages were isolated from wild type (WT) mice and from mice invalidated for the P2X(7) receptor (KO) which had been pretreated with thioglycolate. In cells from WT mice, 1 mM ATP increased the intracellular concentration of calcium ([Ca(2+)](i)), the uptake of ethidium bromide, the production of reactive oxygen species (ROS), the secretion of IL-1beta, the release of oleic acid and of lactate dehydrogenase; it decreased the intracellular concentration of potassium ([K(+)](i)). In KO mice, ATP transiently increased the [Ca(2+)](i) confirming that the P2X(7) receptor is a major receptor of peritoneal macrophages. WKYMVm, an agonist of receptors for formylated peptides (FPR) also increased the [Ca(2+)](i) in murine macrophages. The slight increase of the [Ca(2+)](i) was strongly potentiated by ivermectin confirming the expression of functional P2X(4) receptors by murine peritoneal macrophages. CRAMP, the unique antimicrobial peptide derived from cathelin in mouse inhibited all the responses coupled to P2X(7) receptors in macrophages from WT mice. Agonists for FPR had no effect on the increase of the [Ca(2+)](i) in response to ATP. CRAMP had no effect on the increase of the [Ca(2+)](i) evoked by a combination of ATP and ivermectin in macrophages from P2X(7)-KO mice. In summary CRAMP inhibits the responses secondary to the activation of the murine P2X(7) receptors expressed by peritoneal macrophages. This inhibition is not mediated by FPR receptors and is specific since CRAMP has no effect on the response coupled to P2X(4) receptors. It can thus be concluded that the interaction between P2X(7) receptors and cathelin-derived antimicrobial peptides is species-specific, in some cases (man) positive in others (mouse) negative.Journal Articleinfo:eu-repo/semantics/publishe