Type 2 diabetes, but not obesity, prevalence is positively associated with ambient temperature

Acknowledgements This study was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13030000), the National Science foundation of China (microevolution program NSFC91431102) and the 1000 talents program. We are grateful to members of the Molecular Energetics group in Beijing and the Energetics group in Aberdeen, UK for valuable discussion of the data and analysis. All data analysed in this paper are already available in the public domain.Peer reviewedPublisher PD

Assessment of babA2 and hsp genotype frequency in Helicobacter pylori specimens isolated from digestive disorders patients

Background and Objective: Helicobacter pylori is the main gastric pathogen in human. BabA2 and Hsp genotypes are essential for enormous clinical outcomes in gastreodeoneal and dyspepsia. This study was done to determine the assessment of babA2 and hsp genotype frequency in Helicobacter pylori specimens isolated from digestive disorders patients. Method: This descriptive-analytic study was carried out on 80 digestive disorders patients in 5 th hospital, Gorgan, northern Iran. Stomach specimen biopsy was taken by a gastroenterologist. Urease test, histopathologic assessment and DNA extraction were performed. The frequency of babA2 and hsp genotypes was determined using poly merase chain reaction. Results: In 80 affected patients with H.pylori, 36, 18 and 26 patients were found to suffer from gastritis, stomach cancer and stomach ulcer, respectively. 51 specimens (63%) were positive babA2 genotype. 49 specimens (61%) were positive hsp genotype. No significant relationship was found between babA2 and hsp geno types with stomach diseases. Conclusion: In spite of positive babA2 and hsp genotype in isolated Helicobacter pylori speicments from digestive disorders patients, this finding was not correlated with type of digestive disorders

Transcriptional regulation of the human ALDH1A1 promoter by the oncogenic homeoprotein TLX1/HOX11

The homeoprotein TLX1, which is essential to spleen organogenesis and oncogenic when aberrantly expressed in immature T cells, functions as a bifunctional transcriptional regulator, being capable of activation or repression depending on cell type and/or promoter context. However, the detailed mechanisms by which it regulates the transcription of target genes such as ALDH1A1 remains to be elucidated. We therefore functionally assessed the ability of TLX1 to regulate ALDH1A1 expression in two hematopoietic cell lines, PER-117 T-leukemic cells and human erythroleukemic (HEL) cells, by use of luciferase reporter and mobility shift assays. We showed that TLX1 physically interacts with the general transcription factor TFIIB via its homeodomain, and identified two activities in respect to TLX1-mediated regulation of the CCAAT box-containing ALDH1A1 promoter. The first involved CCAAT-dependent transcriptional repression via perturbation of GATA factor-containing protein complexes assembled at a non-canonical TATA (GATA) box. A structurally intact homeodomain was essential for repression by TLX1 although direct DNA binding was not required. The second activity, which involved CCAAT-independent transcriptional activation did not require an intact homeodomain, indicating that the activation and repression functions of TLX1 are distinct. These findings confirm ALDH1A1 gene regulation by TLX1 and support an indirect model for TLX1 function, in which protein-protein interactions, rather than DNA binding at specific sites, are crucial for its transcriptional activity

COMPARISON OF SECOND-DEGREE BURNS HEALING TIME IN TWO METHODS OF DRESSING WITH FUNDERMOL HERBAL OINTMENT AND% 1 SILVER SULFADIAZINE OINTMENT‏

BACKGROUND: Burn wounds are one of the health problems in modern societies that are associated with irreparable harms and many side problems for patients and their families. Infection due to burn wounds is the main cause of death in such patients. One of the methods to prevent infection of burn wounds is topical antibiotic ointments. This study aimed to investigate and identify effective ointments to treat burn wounds. For this purpose, the effects of two types of ointment, fundermol and 1% silver sulfadiazine cream on second degree burn wounds were compared. METHODS: This was a clinical trial study conducted in 2008. Using convenient and continuous sampling method, 50 patients referred to Imam Mousa Kazem Burn Injury Clinic in Isfahan, Iran with 2nd degree burn wounds in 1% to 10% surface area were enrolled. The patients were randomly divided into two groups of treatment with fundermol and sulfadiazine and the dressing was changed once a day. The healing time for burn wounds in each patient was recorded in a checklist and data were analyzed by independent t-test via SPSS software. RESULTS: The healing time of burn wounds in the group treated with fundermol was shorter than that in the group treated with sulfadiazine (p < 0.001). CONCLUSIONS: The present study showed that fundermol ointment accelerates burn wound healing. Therefore, fundermol can be introduced as a good replacement for current treatments of burn wounds

Investigating the level of moral distress and its related factors among nurses in mazandaran burn center

Background and purpose: Moral distress is a common phenomenon in nursing professional and burn nurses are constantly faced with making different moral decisions for patients who are in terrible conditions. Therefore, nurses in burn units experience moral distress as mental tension. This study was conducted to determine the severity of moral distress and the factors associated with that in burn nurses. Materials and methods: A descriptive- analytical study was conducted using census sampling on 172 nurses working in Mazandaran burn center, 2014. Data was collected through identifying demographic and occupational characteristics of the nurses (using relevant questionnaires) and Corley’s Moral Distress Scale. Data analysis was performed applying Mann-Whitney and Kruskal-Wallis test. Results: The mean score for moral distress was 105.65±52.39 which indicates a moderate level experienced by nurses. Kruskal-Wallis test showed a significant positive correlation between educational level and level of moral distress (P=0.011). There was no significant association between moral distress and other individual and professional characteristics (P>0.05). Conclusion: Moral distress is accompanied by many complications that have direct effects on nurses’ professional practice. Therefore, nurse managers should consider this issue and plan for programs on appropriate coping strategies. © 2015, Mazandaran University of Medical Sciences. All rights reserved

Interoperability and Quality Assurance for Multi-Vendor LTE Network

The deployment of the LTE is picking up pace in many countries and these networks are deployed alongside the existing 2G/3G services. LTE/LTE-A networks offer higher data rates and reduced delay to the subscribers. Today's mobile networks consist of equipment from multiple vendors and they are called multiple vendor networks. Interoperability testing is important at initial network launch and during network expansion. This paper discusses a typical problem related to interoperability testing along with the test results and the issues faced during the testing. The test results discussed in the paper are obtained from three scenarios - before testing, during testing and after testing. The test results are used to study the impact on network performance. Apart from the interoperability testing, an outline of testing that focus on general network stability, the interworking capability of LTE with other technologies such as 2G and 3G and taxonomy for the generation of key performance indicators (KPIs) are also discussed

Compositional Analysis and Antioxidant Activity of Volatile Components of Two Salvia spp

Purpose: To identify and compare the composition of volatile components of two Salvia species, and also their free radical scavenging activity.Method: The essential oil of two Salvia species was analyzed using gas chromatography-mass spectroscopy (GC-MS) techniques while their phenolic contents were analyzed by high performance liquid chromatography (HPLC). The in vitro antioxidant activity of the essential oils was evaluated by 1, 1-diphenyl-2 picryl hydrazyl (DPPH) radical scavenging technique.Results: Seven derivatives were identified for S. verticillata and four derivatives for S. suffruticosa. For both species, the main compounds were 1, 8-cineole (S. suffruticosa: 31.21 % and S. verticillata: 38.26 %) and camphor (S. suffruticosa: 27.11 % and S. verticillata: 22.98 %). The content of the phenolic compounds was: ascorbic acid (S. suffruticosa: 23.98 % and S. verticillata: 33.53 %), p- hydroxyl benzoic acid (S. suffruticosa 11.50 % and S. verticillata 3.83 %), vanilic acid (S. suffruticosa 5.86% and S. verticillata: 6.55 %), syringic acid (S. suffruticosa 6.29 %), ferulic acid (S. suffruticosa: 6.35 % and S. verticillata 6.04 %) and sinapic acid (S. suffruticosa 6.26 % and S. verticillata 4.93%). DPPH radical scavenging ability was 0.548 % for S. suffruticosa for S. suffruticosa and 0.558 % for S. verticillata.Conclusion: The results of this study demonstrated that these two species are rich in 1, 8-cineole, camphor and phenolic compounds. There is no significant difference between the radical scavenging activities of the two essential oils.Keywords: S. verticillata, S. suffruticosa, essential oil, antioxidant activity, GC-MS, HPLC activit

Intra-Abdominal Pressure Monitoring By Nurses For Early Detection Of Abdominal Compartment Syndrome And Early Decompressed Laparotomy In Comparison With Need To Laparotomy By Physical Exam.

Abstract:Background& Objective:Abdominal compartment syndrome is as potentially lethal condition caused by any event that produces intra-abdominal hypertension. The most common cause is blunt abdominal trauma. Increasing intra-abdominal pressure affects much vital body system. Hemodynamic, respiratory, renal and neurological abnormalities are hallmark of ACS. All authors are agreeing that decompression laparotomy is the treatment of choice for the ACS. Nursing care involves vigilant monitoring for early detection including serial measurement of intra-abdominal pressure (from urinary bladder). This study was designed to investigate the comparative effect of measurement of intra-abdominal pressure and physical exam in patient with ACS for refer the patients to operation room. Methodology:In this research ACS was defined as abdominal distention with intra-abdominal pressure ≥15 mm Hg (20cm H2O) accompanied by at least two of the following: oliguria or anuria, hypoxemia and hypotension or shock. When ACS detected by researcher, compared with diagnose of need to laparotomy by physician both timely and numerically.Results:Of 100 patients admitted over 8 months, 28 patients had abdominal compartment syndrome, 21 of this patients refer to operation room by physician. According to numeral comparison between two group not significant (P>.05) but according the time measuring abdominal pressure for detection of need to decompressed laparotomy significantly decreased than physical exam (p<.05).Conclusion:The ACS is a potentially lethal condition occurs in a significant number of severely blunt abdominal trauma patients and it develops quickly. Preventative therapy should be instituted to minimize its development in patients at risk and monitoring of intraabdominal pressure may allow prompt treatment of this condition rather than physical exam