487 research outputs found
Four-dimensional lattice results on the MSSM electroweak phase transition
We present the results of our large scale 4-dimensional (4d) lattice
simulations for the MSSM electroweak phase transition (EWPT). We carried out
infinite volume and continuum limit extrapolations and found a transition whose
strength agrees well with perturbation theory. We determined the properties of
the bubble wall that are important for a successful baryogenesis.Comment: 5 pages, 3figures. Talk presented at Johns Hopkins Workshop on
Nonperturbative Quantum Field Theory Methods and their Applications (19-21
August 2000.
Electroweak Phase Transition in the MSSM: 4-Dimensional Lattice Simulations
Recent lattice results have shown that there is no Standard Model (SM)
electroweak phase transition (EWPT) for Higgs boson masses above \approx 72
GeV, which is below the present experimental limit. According to perturbation
theory and 3-dimensional (3d) lattice simulations there could be an EWPT in the
Minimal Supersymmetric Standard Model (MSSM) that is strong enough for
baryogenesis up to m_h \approx 105 GeV. In this letter we present the results
of our large scale 4-dimensional (4d) lattice simulations for the MSSM EWPT. We
carried out infinite volume and continuum limits and found a transition whose
strength agrees well with perturbation theory, allowing MSSM electroweak
baryogenesis at least up to m_h = 103 \pm 4 GeV. We determined the properties
of the bubble wall that are important for a successful baryogenesis.Comment: 4 pages, 4 figures included; lightest Higgs mass bound relaxed
(abstract, fig. 3 changed), version to appear in Phys. Rev. Letter
Stapled Peptides as HIFâ1α/p300 Inhibitors: Helicity Enhancement in the Bound State Increases Inhibitory Potency
Proteinâprotein interactions (PPIs) control virtually all cellular processes and have thus emerged as potential targets for development of molecular therapeutics. Peptideâbased inhibitors of PPIs are attractive given that they offer recognition potency and selectivity features that are ideal for function, yet, they do not predominantly populate the bioactive conformation, frequently suffer from poor cellular uptake and are easily degraded, for example, by proteases. The constraint of peptides in a bioactive conformation has emerged as a promising strategy to mitigate against these liabilities. In this work, using peptides derived from hypoxiaâinducible factor 1 (HIFâ1α) together with dibromomaleimide stapling, we identify constrained peptide inhibitors of the HIFâ1α/p300 interaction that are more potent than their unconstrained sequences. Contrary to expectation, the increased potency does not correlate with an increased population of an αâhelical conformation in the unbound state as demonstrated by experimental circular dichroism analysis. Rather, the ability of the peptide to adopt a bioactive αâhelical conformation in the p300 bound state is better supported in the constrained variant as demonstrated by molecular dynamics simulations and circular dichroism difference spectra
Towards identification of protein-protein interaction stabilizers via inhibitory peptide-fragment hybrids using templated fragment ligation
Using the hDMX/14-3-3 interaction, acylhydrazone-based ligand-directed fragment ligation was used to identify proteinâprotein interaction (PPI) inhibitory peptide-fragment hybrids. Separation of the peptide-fragment hybrids into the components yielded fragments that stabilized the hDMX/14-3-3 interaction
Contour deformation trick in hybrid NLIE
The hybrid NLIE of AdS_5 x S^5 is applied to a wider class of states. We find
that the Konishi state of the orbifold AdS_5 x (S^5/Z_S) satisfies A_1 NLIE
with the source terms which are derived from contour deformation trick. For
general states, we construct a deformed contour with which the contour
deformation trick yields the correct source terms.Comment: 39 pages, 6 figures, v2: discussion on analyticity constraints
replaced by consistent deformed contou
Konishi operator at intermediate coupling
TBA equations for two-particle states from the sl(2) sector proposed by
Arutyunov, Suzuki and the author are solved numerically for the Konishi
operator descendent up to 't Hooft's coupling lambda ~ 2046. The data obtained
is used to analyze the properties of Y-functions and address the issue of the
existence of the critical values of the coupling. In addition we find a new
integral representation for the BES dressing phase which substantially reduces
the computational time.Comment: lots of figures, v2: improved numerics, c1=2, c2=0, c4 does not
vanis
Hybrid-NLIE for the AdS/CFT spectral problem
Hybrid-NLIE equations, an alternative finite NLIE description for the
spectral problem of the super sigma model of AdS/CFT and its gamma-deformations
are derived by replacing the semi-infinite SU(2) and SU(4) parts of the AdS/CFT
TBA equations by a few appropriately chosen complex NLIE variables, which are
coupled among themselves and to the Y-functions associated to the remaining
central nodes of the TBA diagram. The integral equations are written explicitly
for the ground state of the gamma-deformed system. We linearize these NLIE
equations, analytically calculate the first correction to the asymptotic
solution and find agreement with analogous results coming from the original TBA
formalism. Our equations differ substantially from the recently published
finite FiNLIE formulation of the spectral problem.Comment: 63 pages, 1 figur
Five-loop anomalous dimension at critical wrapping order in N=4 SYM
We compute the anomalous dimension of a length-five operator at five-loop
order in the SU(2) sector of N=4 SYM theory in the planar limit. This is
critical wrapping order at five loops. The result is obtained perturbatively by
means of N=1 superspace techniques. Our result from perturbation theory
confirms explicitly the formula conjectured in arXiv:0901.4864 for the
five-loop anomalous dimension of twist-three operators. We also explicitly
obtain the same result by employing the recently proposed Y-system.Comment: LaTeX, feynmp, 34 pages, 21 figures, 8 table
Exploring the mirror TBA
We apply the contour deformation trick to the Thermodynamic Bethe Ansatz
equations for the AdS_5 \times S^5 mirror model, and obtain the integral
equations determining the energy of two-particle excited states dual to N=4 SYM
operators from the sl(2) sector. We show that each state/operator is described
by its own set of TBA equations. Moreover, we provide evidence that for each
state there are infinitely-many critical values of 't Hooft coupling constant
\lambda, and the excited states integral equations have to be modified each
time one crosses one of those. In particular, estimation based on the large L
asymptotic solution gives \lambda \approx 774 for the first critical value
corresponding to the Konishi operator. Our results indicate that the related
calculations and conclusions of Gromov, Kazakov and Vieira should be
interpreted with caution. The phenomenon we discuss might potentially explain
the mismatch between their recent computation of the scaling dimension of the
Konishi operator and the one done by Roiban and Tseytlin by using the string
theory sigma model.Comment: 69 pages, v2: new "hybrid" equations for YQ-functions, figures and
tables are added. Analyticity of Y-system is discussed, v3: published versio
Absence of miRNA-146a Differentially Alters Microglia Function and Proteome
Background: MiR-146a is an important regulator of innate inflammatory responses and is also implicated in cell death and survival. Methods: By sorting CNS resident cells, microglia were the main cellular source of miR-146a. Therefore, we investigated microglia function and phenotype in miR-146a knock-out (KO) mice, analyzed the proteome of KO and wild-type (WT) microglia by LC-MS/MS, and examined miR-146a expression in different brain lesions of patients with multiple sclerosis (MS). Results: When stimulated with LPS or myelin in vitro, microglia from KO mice expressed higher levels of IL-1ÎČ, TNF, IL-6, IL-10, CCL3, and CCL2 compared to WT. Stimulation increased migration and phagocytosis of WT but not KO microglia. CD11c+ microglia were induced by cuprizone (CPZ) in the WT mice but less in the KO. The proteome of ex vivo microglia was not different in miR-146a KO compared to WT mice, but CPZ treatment induced differential and reduced protein responses in the KO: GOT1, COX5b, CRYL1, and cystatin-C were specifically changed in KO microglia. We explored discriminative features of microglia proteomes: sparse Partial Least Squares-Discriminant Analysis showed the best discrimination when control and CPZ-treated conditions were compared. Cluster of ten proteins separated WT and miR-146a KO microglia after CPZ: among them were sensomes allowing to perceive the environment, Atp1a3 that belongs to the signature of CD11c+ microglia, and proteins related to inflammatory responses (S100A9, Ppm1g). Finally, we examined the expression of miR-146a and its validated target genes in different brain lesions of MS patients. MiR-146 was upregulated in all lesion types, and the highest expression was in active lesions. Nineteen of 88 validated target genes were significantly changed in active lesions, while none were changed in NAWM. Conclusion: Our data indicated that microglia is the major source of miR-146a in the CNS. The absence of miR-146a differentially affected microglia function and proteome, and miR-146a may play an important role in gene regulation of active MS lesions
- âŠ