Cornesti-Iarcuri - a Bronze Age town in the Romanian Banat?

©2011 Antiquity PublicationsA massive Late Bronze Age fortified settlement in Central Europe has been the subject of a new and exemplary investigation by excavation and site survey. This prehistoric enclosure, nearly 6km across, had a complex development, dense occupation and signs of destruction by fire. It can hardly be other than a capital city playing a role in the determinant struggles of its day — weighty and far reaching events of the European continent now being chronicled by archaeology.Funding for the project has been provided by the Fritz-Thyssen-Stiftung, K¨oln, the County Council of Timis¸ and the Muzeul Banatului Timis¸oara

Early and Long-Term Effects of Dupilumab Treatment on Circulating T-Cell Functions in Patients with Moderate-to-Severe Atopic Dermatitis

Dupilumab, a mAb targeting IL-4 receptor alpha (IL-4Rα), markedly improves disease severity in patients with atopic dermatitis. However, the effect of IL-4Rα blockade on dynamics of circulating skin-homing T cells, which are crucial players in the pathologic mechanism of atopic dermatitis, has not been studied yet. In addition, it remains unknown whether dupilumab treatment induces long-lasting T- and B-cell polarization. Therefore, we studied the short- and long-term effects of dupilumab treatment on IL-4Rα expression and T-cell cytokine production within total and skin-homing (cutaneous lymphocyte antigen+/CCR4+) subpopulations in patients with moderate-to-severe atopic dermatitis. Dupilumab treatment completely blocked IL-4Rα expression and signal transducer and activator of transcription 6 phosphorylation in CD19+ B cells and CD4+ T cells within 2 hours of administration and through week 52. Although no change in the proportion of skin-homing T-cell subsets was found, dupilumab treatment significantly decreased the percentage of proliferating (Ki67+) and T helper type 2 and T helper type 22 cytokine-producing skin-homing CD4+ T cells at week 4. No evidence of general T helper type cell skewing following a year of dupilumab treatment was found. In summary, dupilumab treatment rapidly and stably inhibited IL-4Rα, which was accompanied by a strong early functional immunological effect specifically on skin-homing T cells without affecting overall T helper type cell skewing in the long term

Copper shaft-hole axes and early metallurgy in south-eastern Europe: an integrated approach

Although the copper axes with central shaft-hole from south-eastern Europe have a long history of research, they have not been studied on a transnational basis since the 1960s. What has also been missing is an integrated or holistic approach, trying to use as many methods as possible and better understand the production, use and context of these enigmatic objects. This present research therefore approaches the axes from different angles. A database was compiled in order to find answers on questions such as the patterns of distribution, context, fragmentation and deformation of axes. For the distribution of axes in general as well as different attributes like fragmentation and typology, the content of the database was imported into GIS software and analysed. Aspects of production were considered through experimental archaeology, metallographic analysis and a re-discovered axe blank with missing shafthole. Especially the missing moulds make it difficult to fully understand the production sequence. The typology was re-evaluated and modified to ensure comparability across modern national boundaries. The context and background was developed through a thorough review of the literature and combined with theoretical considerations. The integration of all these approaches yielded some interesting results. The great variability in shape combined with the results of metallographic analyses clearly shows that a variety of production techniques were used, but it is as yet difficult to relate these to specific geographic areas or even cultural groups. In fact the typology as well as the practice of marking the axes indicate that traditional archaeological ‘cultures’ rarely correspond to the distribution of a type or to the practice of marking the axes. They show instead that there were different spheres of influence, some even more localised and others much larger (like the Carpathian Basin) than specific ceramic traditions. These different levels of belonging, as well as the increasing visibility of the individual in the archaeological record, show that it was a period of complex cultural patterns and interactions. The axes were a part of these networks of the daily life on many different levels from the strict utilitarian to the ritualised placement in burial contexts.AHR

Copper shaft-hole axes and early metallurgy in south-eastern Europe : an integrated approach

Although the copper axes with central shaft-hole from south-eastern Europe have a long history of research, they have not been studied on a transnational basis since the 1960s. What has also been missing is an integrated or holistic approach, trying to use as many methods as possible and better understand the production, use and context of these enigmatic objects. This present research therefore approaches the axes from different angles. A database was compiled in order to find answers on questions such as the patterns of distribution, context, fragmentation and deformation of axes. For the distribution of axes in general as well as different attributes like fragmentation and typology, the content of the database was imported into GIS software and analysed. Aspects of production were considered through experimental archaeology, metallographic analysis and a re-discovered axe blank with missing shafthole. Especially the missing moulds make it difficult to fully understand the production sequence. The typology was re-evaluated and modified to ensure comparability across modern national boundaries. The context and background was developed through a thorough review of the literature and combined with theoretical considerations. The integration of all these approaches yielded some interesting results. The great variability in shape combined with the results of metallographic analyses clearly shows that a variety of production techniques were used, but it is as yet difficult to relate these to specific geographic areas or even cultural groups. In fact the typology as well as the practice of marking the axes indicate that traditional archaeological ‘cultures’ rarely correspond to the distribution of a type or to the practice of marking the axes. They show instead that there were different spheres of influence, some even more localised and others much larger (like the Carpathian Basin) than specific ceramic traditions. These different levels of belonging, as well as the increasing visibility of the individual in the archaeological record, show that it was a period of complex cultural patterns and interactions. The axes were a part of these networks of the daily life on many different levels from the strict utilitarian to the ritualised placement in burial contexts.EThOS - Electronic Theses Online ServiceAHRCGBUnited Kingdo