The Status of Licensed Professional Counselors in Michigan Public Universities

This article documents the findings of a study investigating the employment status of licensed professional counselors in Michigan’s 15 public universities. Structured interviews were conducted by telephone with 85 professionals working in college counseling centers, career centers, advising, admissions, financial aid, and residence life offices. The results indicated that only a very small percentage of employees in these offices are licensed as professional counselors, and a substantial number have not received training in counseling

SEAD Virtual Archive: Building a Federation of Institutional Repositories for Long Term Data Preservation

Major research universities are grappling with their response to the deluge of scientific data emerging through research by their faculty. Many are looking to their libraries and the institutional repository as a solution. Scientific data introduces substantial challenges that the document-based institutional repository may not be suited to deal with. The Sustainable Environment - Actionable Data (SEAD) Virtual Archive specifically addresses the challenges of “long tail” scientific data. In this paper, we propose requirements, policy and architecture to support not only the preservation of scientific data today using institutional repositories, but also its rich access and use into the future

AnkyrinG is required for maintenance of the axon initial segment and neuronal polarity

The axon initial segment (AIS) functions as both a physiological and physical bridge between somatodendritic and axonal domains. Given its unique molecular composition, location, and physiology, the AIS is thought to maintain neuronal polarity. To identify the molecular basis of this AIS property, we used adenovirus-mediated RNA interference to silence AIS protein expression in polarized neurons. Some AIS proteins are remarkably stable with half-lives of at least 2 wk. However, silencing the expression of the cytoskeletal scaffold ankyrinG (ankG) dismantles the AIS and causes axons to acquire the molecular characteristics of dendrites. Both cytoplasmic- and membrane-associated proteins, which are normally restricted to somatodendritic domains, redistribute into the former axon. Furthermore, spines and postsynaptic densities of excitatory synapses assemble on former axons. Our results demonstrate that the loss of ankG causes axons to acquire the molecular characteristics of dendrites; thus, ankG is required for the maintenance of neuronal polarity and molecular organization of the AIS

βIV spectrin is recruited to axon initial segments and nodes of Ranvier by ankyrinG

High densities of ion channels at axon initial segments (AISs) and nodes of Ranvier are required for initiation, propagation, and modulation of action potentials in axons. The organization of these membrane domains depends on a specialized cytoskeleton consisting of two submembranous cytoskeletal and scaffolding proteins, ankyrinG (ankG) and βIV spectrin. However, it is not known which of these proteins is the principal organizer, or if the mechanisms governing formation of the cytoskeleton at the AIS also apply to nodes. We identify a distinct protein domain in βIV spectrin required for its localization to the AIS, and show that this domain mediates βIV spectrin's interaction with ankG. Dominant-negative ankG disrupts βIV spectrin localization, but does not alter endogenous ankG or Na+ channel clustering at the AIS. Finally, using adenovirus for transgene delivery into myelinated neurons, we demonstrate that βIV spectrin recruitment to nodes of Ranvier also depends on binding to ankG

Estimates in Beurling--Helson type theorems. Multidimensional case

We consider the spaces $A_p(\mathbb T^m)$ of functions $f$ on the $m$ -dimensional torus $\mathbb T^m$ such that the sequence of the Fourier coefficients $\hat{f}=\{\hat{f}(k), ~k \in \mathbb Z^m\}$ belongs to $l^p(\mathbb Z^m), ~1\leq p<2$. The norm on $A_p(\mathbb T^m)$ is defined by $\|f\|_{A_p(\mathbb T^m)}=\|\hat{f}\|_{l^p(\mathbb Z^m)}$. We study the rate of growth of the norms $\|e^{i\lambda\varphi}\|_{A_p(\mathbb T^m)}$ as $|\lambda|\rightarrow \infty, ~\lambda\in\mathbb R,$ for $C^1$ -smooth real functions $\varphi$ on $\mathbb T^m$ (the one-dimensional case was investigated by the author earlier). The lower estimates that we obtain have direct analogues for the spaces $A_p(\mathbb R^m)$

Coupled wind-forced controls of the Bering–Chukchi shelf circulation and the Bering Strait throughflow: Ekman transport, continental shelf waves, and variations of the Pacific–Arctic sea surface height gradient

AbstractWe develop a conceptual model of the closely co-dependent Bering shelf, Bering Strait, and Chukchi shelf circulation fields by evaluating the effects of wind stress over the North Pacific and western Arctic using atmospheric reanalyses, current meter observations, satellite-based sea surface height (SSH) measurements, hydrographic profiles, and numerical model integrations. This conceptual model suggests Bering Strait transport anomalies are primarily set by the longitudinal location of the Aleutian Low, which drives oppositely signed anomalies at synoptic and annual time scales. Synoptic time scale variations in shelf currents result from local wind forcing and remotely generated continental shelf waves, whereas annual variations are driven by basin scale adjustments to wind stress that alter the magnitude of the along-strait (meridional) pressure gradient. In particular, we show that storms centered over the Bering Sea excite continental shelf waves on the eastern Bering shelf that carry northward velocity anomalies northward through Bering Strait and along the Chukchi coast. The integrated effect of these storms tends to decrease the northward Bering Strait transport at annual to decadal time scales by imposing cyclonic wind stress curl over the Aleutian Basin and the Western Subarctic Gyre. Ekman suction then increases the water column density through isopycnal uplift, thereby decreasing the dynamic height, sea surface height, and along-strait pressure gradient. Storms displaced eastward over the Gulf of Alaska generate an opposite set of Bering shelf and Aleutian Basin responses. While Ekman pumping controls Canada Basin dynamic heights (Proshutinsky et al., 2002), we do not find evidence for a strong relation between Beaufort Gyre sea surface height variations and the annually averaged Bering Strait throughflow. Over the western Chukchi and East Siberian seas easterly winds promote coastal divergence, which also increases the along-strait pressure head, as well as generates shelf waves that impinge upon Bering Strait from the northwest

Absorbing boundary conditions for the Westervelt equation

The focus of this work is on the construction of a family of nonlinear absorbing boundary conditions for the Westervelt equation in one and two space dimensions. The principal ingredient used in the design of such conditions is pseudo-differential calculus. This approach enables to develop high order boundary conditions in a consistent way which are typically more accurate than their low order analogs. Under the hypothesis of small initial data, we establish local well-posedness for the Westervelt equation with the absorbing boundary conditions. The performed numerical experiments illustrate the efficiency of the proposed boundary conditions for different regimes of wave propagation

Identification of Novel Mt-Guab2 Inhibitor Series Active against M. tuberculosis

Tuberculosis (TB) remains a leading cause of mortality worldwide. With the emergence of multidrug resistant TB, extensively drug resistant TB and HIV-associated TB it is imperative that new drug targets be identified. The potential of Mycobacterium tuberculosis inosine monophosphate dehydrogenase (IMPDH) as a novel drug target was explored in the present study. IMPDH exclusively catalyzes the conversion of inosine monophosphate (IMP) to xanthosine monophosphate (XMP) in the presence of the cofactor nicotinamide adenine dinucleotide (NAD+). Although the enzyme is a dehydrogenase, the enzyme does not catalyze the reverse reaction i.e. the conversion of XMP to IMP. Unlike other bacteria, M. tuberculosis harbors three IMPDH-like genes, designated as Mt-guaB1, Mt-guaB2 and Mt-guaB3 respectively. Of the three putative IMPDH's, we previously confirmed that Mt-GuaB2 was the only functional ortholog by characterizing the enzyme kinetically. Using an in silico approach based on designed scaffolds, a series of novel classes of inhibitors was identified. The inhibitors possess good activity against M. tuberculosis with MIC values in the range of 0.4 to 11.4 µg mL−1. Among the identified ligands, two inhibitors have nanomolar Kis against the Mt-GuaB2 enzyme